In search of AKT kinase inhibitors as anticancer agents: structure-based design, docking, and molecular dynamics studies of 2,4,6-trisubstituted pyridines

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(2018)   Molecular Informatics

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(2016)   CA-A CANCER JOURNAL FOR CLINICIANS

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(2016)   JOURNAL OF COMPUTATIONAL CHEMISTRY

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(2016)   BRITISH JOURNAL OF PHARMACOLOGY

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(2016)   INTERNATIONAL JOURNAL OF CANCER

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(2016)   JOURNAL OF COMPUTATIONAL CHEMISTRY

AKT1 Activation Promotes Development of Melanoma Metastases

(2015) Joseph H. Cho et al.   Cell Reports

g_mmpbsa—A GROMACS Tool for High-Throughput MM-PBSA Calculations

(2014) Rashmi Kumari et al.   Journal of Chemical Information and Modeling

Targeting PI3K/Akt/mTOR Signaling in Cancer

(2014) Camillo Porta et al.   Frontiers in Oncology

Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway

(2013) Howard A. Burris   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Targeting Akt3 Signaling in Triple-Negative Breast Cancer

(2013) Y. R. Chin et al.   CANCER RESEARCH

Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology

(2013) Paul Workman et al.   CURRENT OPINION IN PHARMACOLOGY

Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases

(2013) Matt Addie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

(2013) Jiri Polivka et al.   PHARMACOLOGY & THERAPEUTICS

Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells

(2011) Nicole Grabinski et al.   CELLULAR SIGNALLING

Novel Inhibitors of AKT: Assessment of a Different Approach Targeting the Pleckstrin Homology Domain

(2011) E. J. Meuillet   CURRENT MEDICINAL CHEMISTRY

Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape

(2011) Margrith E Mattmann et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The effect Akt2 deletion on tumor development in Pten+/− mice

(2011) P-Z Xu et al.   ONCOGENE

Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations

(2010) Tingjun Hou et al.   Journal of Chemical Information and Modeling

Signal transduction therapy of cancer

(2010) Alexander Levitzki et al.   MOLECULAR ASPECTS OF MEDICINE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Discovery of a novel protein kinase B inhibitor by structure-based virtual screening

(2009) Jose L. Medina-Franco et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Aminofurazans as potent inhibitors of AKT kinase

(2009) Meagan B. Rouse et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Akt1/protein Kinase Bα is Involved in Gastric Cancer Progression and Cell Proliferation

(2008) Zheyi Han et al.   DIGESTIVE DISEASES AND SCIENCES