PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation

New targeted approaches for epigenetic age predictions

(2020) Yang Han et al.   BMC BIOLOGY

Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes

(2019) Anna Maierhofer et al.   AGING CELL

Exploring the Relationship of Relative Telomere Length and the Epigenetic Clock in the LipidCardio Cohort

(2019) Verena L. Banszerus et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparison of flow‐FISH and MM–qPCR telomere length assessment techniques for the screening of telomeropathies

(2019) Monica S. Ventura Ferreira et al.   Annals of the New York Academy of Sciences

LIFE-COURSE LONGITUDINAL STUDIES ARE NEEDED TO ADVANCE INTEGRATION OF GENOMICS AND SOCIAL EPIDEMIOLOGY

(2018) Daniel W Belsky   AMERICAN JOURNAL OF EPIDEMIOLOGY

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

(2018) Steve Horvath et al.   Aging-US

PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature

(2018) David J. Corrigan et al.   JOURNAL OF CLINICAL INVESTIGATION

DNA Methylation Clocks in Aging: Categories, Causes, and Consequences

(2018) Adam E. Field et al.   MOLECULAR CELL

Aplastic Anemia

(2018) Neal S. Young   NEW ENGLAND JOURNAL OF MEDICINE

Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

(2017) Nard Kubben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

The role of PRDMs in cancer: one family, two sides

(2016) Slim Mzoughi et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex

(2016) Mayuko Inoue et al.   DEVELOPMENT

The epigenetic clock and telomere length are independently associated with chronological age and mortality

(2016) Riccardo E Marioni et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

DNA methylation in PRDM8 is indicative for dyskeratosis congenita

(2016) Carola I. Weidner et al.   Oncotarget

Frailty is associated with the epigenetic clock but not with telomere length in a German cohort

(2016) Lutz Philipp Breitling et al.   Clinical Epigenetics

Accelerated epigenetic aging in Down syndrome

(2015) Steve Horvath et al.   AGING CELL

Deletion of Prdm8 impairs development of upper-layer neocortical neurons

(2015) Mayuko Inoue et al.   GENES TO CELLS

Clinical and genetic features of dyskeratosis congenita, cryptic dyskeratosis congenita, and Hoyeraal-Hreidarsson syndrome in Japan

(2015) Hiroki Yamaguchi et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Epigenetic Biomarker to Support Classification into Pluripotent and Non-Pluripotent Cells

(2015) Michael Lenz et al.   Scientific Reports

Efficient Generation of Megakaryocytes From Human Induced Pluripotent Stem Cells Using Food and Drug Administration-Approved Pharmacological Reagents

(2015) Yanfeng Liu et al.   Stem Cells Translational Medicine

Bone marrow failure and the telomeropathies

(2014) D. M. Townsley et al.   BLOOD

Clinical utility gene card for: Dyskeratosis congenita – update 2015

(2014) Inderjeet Dokal et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Telomere length in inherited bone marrow failure syndromes

(2014) B. P. Alter et al.   HAEMATOLOGICA

Aging of blood can be tracked by DNA methylation changes at just three CpG sites

(2014) Carola Weidner et al.   GENOME BIOLOGY

Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging

(2014) Hoi-Hung Cheung et al.   Stem Cell Reports

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Prdm3 and Prdm16 are H3K9me1 Methyltransferases Required for Mammalian Heterochromatin Integrity

(2012) Inês Pinheiro et al.   CELL

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

Bhlhb5 and Prdm8 Form a Repressor Complex Involved in Neuronal Circuit Assembly

(2012) Sarah E. Ross et al.   NEURON

PRDM proteins: Important players in differentiation and disease

(2011) Cathrine K. Fog et al.   BIOESSAYS

PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function

(2011) Y. Zhang et al.   BLOOD

Prdm16 is a physiologic regulator of hematopoietic stem cells

(2011) F. Aguilo et al.   BLOOD

Dyskeratosis Congenita

(2011) I. Dokal   Hematology-American Society of Hematology Education Program

A role for Blimp1 in the transcriptional network controlling natural killer cell maturation

(2010) A. Kallies et al.   BLOOD

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress

(2010) Sergei Chuikov et al.   NATURE CELL BIOLOGY

Histone methyltransferase PRDM8 regulates mouse testis steroidogenesis

(2009) Gwang Hyeon Eom et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Advances in the understanding of dyskeratosis congenita

(2009) Amanda J. Walne et al.   BRITISH JOURNAL OF HAEMATOLOGY

Dyskeratosis Congenita

(2009) Sharon A. Savage et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Transcriptional Repressor Blimp-1 Promotes CD8+ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell Properties

(2009) Rachel L. Rutishauser et al.   IMMUNITY

Telomere maintenance and human bone marrow failure

(2008) R. T. Calado et al.   BLOOD

Evi-1 Is a Critical Regulator for Hematopoietic Stem Cells and Transformed Leukemic Cells

(2008) Susumu Goyama et al.   Cell Stem Cell