PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML

(2018) Delfim Duarte et al.   Cell Stem Cell

Clinical features and prognostic impact of PRDM16 expression in adult acute myeloid leukemia

(2017) Genki Yamato et al.   GENES CHROMOSOMES & CANCER

Success in bone marrow failure? Novel therapeutic directions based on the immune environment of myelodysplastic syndromes

(2017) Alyssa H. Cull et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Flow cytometry based monocyte subset analysis accurately distinguishes chronic myelomonocytic leukemia from myeloproliferative neoplasms with associated monocytosis

(2017) M M Patnaik et al.   Blood Cancer Journal

Inflammatory Signaling Pathways in Preleukemic and Leukemic Stem Cells

(2017) Shayda Hemmati et al.   Frontiers in Oncology

Pyruvate dehydrogenase kinase 1 is essential for transplantable mouse bone marrow hematopoietic stem cell and progenitor function

(2017) Camilla Halvarsson et al.   PLoS One

The role of PRDMs in cancer: one family, two sides

(2016) Slim Mzoughi et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Leukemia cell infiltration causes defective erythropoiesis partially through MIP-1α/CCL3

(2016) Y Wang et al.   LEUKEMIA

PRDM16 Suppresses MLL1r Leukemia via Intrinsic Histone Methyltransferase Activity

(2016) Bo Zhou et al.   MOLECULAR CELL

Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential

(2016) Larry L. Luchsinger et al.   NATURE

PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements

(2016) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology

(2016) John R. Shaffer et al.   PLoS Genetics

HighPRDM16expression identifies a prognostic subgroup of pediatric acute myeloid leukaemia correlated toFLT3-ITD,KMT2A-PTD, andNUP98-NSD1: the results of the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 trial

(2015) Norio Shiba et al.   BRITISH JOURNAL OF HAEMATOLOGY

The subtype-specific features of EVI1 and PRDM16 in acute myeloid leukemia

(2015) H. Matsuo et al.   HAEMATOLOGICA

The closely related rare and severe acute myeloid leukemias carrying EVI1 or PRDM16 rearrangements share singular biological features

(2015) M. Eveillard et al.   HAEMATOLOGICA

The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting

(2015) J. Wang et al.   JOURNAL OF CELL SCIENCE

High expression of EVI1 and MEL1 is a compelling poor prognostic marker of pediatric AML

(2015) A Jo et al.   LEUKEMIA

Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells

(2015) D H Spencer et al.   LEUKEMIA

Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

(2015) I Gañán-Gómez et al.   LEUKEMIA

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways

(2015) Javed K. Manesia et al.   Stem Cell Research

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

(2015) Maria Maryanovich et al.   Nature Communications

The subtype-specific features of EVI1 and PRDM16 in acute myeloid leukemia

(2015) H. Matsuo et al.   HAEMATOLOGICA

The closely related rare and severe acute myeloid leukemias carrying EVI1 or PRDM16 rearrangements share singular biological features

(2015) M. Eveillard et al.   HAEMATOLOGICA

Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo

(2014) H. Yu et al.   BLOOD

Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells

(2014) Ramesh C. Nayak et al.   IMMUNOLOGICAL REVIEWS

Lin-Sca1+Kit- Bone Marrow Cells Contain Early Lymphoid-Committed Precursors That Are Distinct from Common Lymphoid Progenitors

(2014) R. Kumar et al.   JOURNAL OF IMMUNOLOGY

Fine Mapping of the 1p36 Deletion Syndrome Identifies Mutation of PRDM16 as a Cause of Cardiomyopathy

(2013) Anne-Karin Arndt et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

(2013) Keiyo Takubo et al.   Cell Stem Cell

RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors

(2013) Xuan Zhou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Large-scale gene function analysis with the PANTHER classification system

(2013) Huaiyu Mi et al.   Nature Protocols

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Prdm3 and Prdm16 are H3K9me1 Methyltransferases Required for Mammalian Heterochromatin Integrity

(2012) Inês Pinheiro et al.   CELL

Less Is More: Unveiling the Functional Core of Hematopoietic Stem Cells through Knockout Mice

(2012) Lara Rossi et al.   Cell Stem Cell

Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation

(2012) Maria Carolina Florian et al.   Cell Stem Cell

Redundant roles of PRDM family members in zebrafish craniofacial development

(2012) Hai-Lei Ding et al.   DEVELOPMENTAL DYNAMICS

Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

(2012) A V Krivtsov et al.   LEUKEMIA

A Genome-Wide Association Study Identifies Five Loci Influencing Facial Morphology in Europeans

(2012) Fan Liu et al.   PLoS Genetics

Prdm16 is a physiologic regulator of hematopoietic stem cells

(2011) F. Aguilo et al.   BLOOD

PRDM16 (1p36) translocations define a distinct entity of myeloid malignancies with poor prognosis but may also occur in lymphoid malignancies

(2011) Francois P. Duhoux et al.   BRITISH JOURNAL OF HAEMATOLOGY

Prdm14 initiates lymphoblastic leukemia after expanding a population of cells resembling common lymphoid progenitors

(2011) E J Dettman et al.   ONCOGENE

Recurrent expression signatures of cytokines and chemokines are present and are independently prognostic in acute myelogenous leukemia and myelodysplasia

(2010) S. M. Kornblau et al.   BLOOD

Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress

(2010) Sergei Chuikov et al.   NATURE CELL BIOLOGY

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

(2010) I. Beerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prdm16 is required for normal palatogenesis in mice

(2009) Bryan C. Bjork et al.   HUMAN MOLECULAR GENETICS

Progenitor Cell Origin Plays a Role in Fate Choices of Mature B Cells

(2009) V. Fossati et al.   JOURNAL OF IMMUNOLOGY

The prognostic significance of cytokine levels in newly diagnosed acute myeloid leukemia and high-risk myelodysplastic syndromes

(2008) Apostolia Maria Tsimberidou et al.   CANCER

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16

(2008) U Modlich et al.   LEUKEMIA

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE