DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice

Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System

(2013) Frederick W. Alt et al.   CELL

Early replication fragile sites: where replication–transcription collisions cause genetic instability

(2013) Oliver Mortusewicz et al.   EMBO JOURNAL

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

Transcription-replication encounters, consequences and genomic instability

(2013) Anne Helmrich et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells

(2013) Ranjit S. Bindra et al.   NUCLEIC ACIDS RESEARCH

DNA Ligases I and III Cooperate in Alternative Non-Homologous End-Joining in Vertebrates

(2013) Katja Paul et al.   PLoS One

Reduced contribution of thermally labile sugar lesions to DNA double strand break formation after exposure to heavy ions

(2013) Satyendra K Singh et al.   Radiation Oncology

DNA double-strand break repair within heterochromatic regions: Figure 1

(2012) Johanne M. Murray et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Spatial Organization of the Mouse Genome and Its Role in Recurrent Chromosomal Translocations

(2012) Yu Zhang et al.   CELL

Human mitotic chromosomes consist predominantly of irregularly folded nucleosome fibres without a 30-nm chromatin structure

(2012) Yoshinori Nishino et al.   EMBO JOURNAL

Open and closed domains in the mouse genome are configured as 10-nm chromatin fibres

(2012) Eden Fussner et al.   EMBO REPORTS

Inhibition of B-NHEJ in Plateau-Phase Cells Is Not a Direct Consequence of Suppressed Growth Factor Signaling

(2012) Satyendra K. Singh et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Keeping It Together in Times of Stress: Checkpoint Function at Stalled Replication Forks

(2012) Theresa J. Berens et al.   MOLECULAR CELL

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

(2012) Jan J. Molenaar et al.   NATURE

The accessible chromatin landscape of the human genome

(2012) Robert E. Thurman et al.   NATURE

Iterative correction of Hi-C data reveals hallmarks of chromosome organization

(2012) Maxim Imakaev et al.   NATURE METHODS

A fractal model for nuclear organization: current evidence and biological implications

(2012) A. Bancaud et al.   NUCLEIC ACIDS RESEARCH

I-SceI-Mediated Double-Strand Break Does Not Increase the Frequency of Homologous Recombination at the Dct Locus in Mouse Embryonic Stem Cells

(2012) Myriam Fenina et al.   PLoS One

Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)

(2012) C. Boboila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling Cell Survival after Photon Irradiation Based on Double-Strand Break Clustering in Megabase Pair Chromatin Loops

(2012) Thomas Friedrich et al.   RADIATION RESEARCH

Dynamics of DNA Supercoils

(2012) M. T. J. van Loenhout et al.   SCIENCE

Constitutional Chromothripsis Rearrangements Involve Clustered Double-Stranded DNA Breaks and Nonhomologous Repair Mechanisms

(2012) Wigard P. Kloosterman et al.   Cell Reports

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Mechanisms that Promote and Suppress Chromosomal Translocations in Lymphocytes

(2011) Monica Gostissa et al.   Annual Review of Immunology

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

(2011) Roberto Chiarle et al.   CELL

The fractal globule as a model of chromatin architecture in the cell

(2011) Leonid A. Mirny   CHROMOSOME RESEARCH

Factors determining DNA double-strand break repair pathway choice in G2 phase

(2011) Atsushi Shibata et al.   EMBO JOURNAL

Radiation-generated Short DNA Fragments May Perturb Non-homologous End-joining and Induce Genomic Instability

(2011) Dalong PANG et al.   JOURNAL OF RADIATION RESEARCH

Heavy charged particle radiobiology: Using enhanced biological effectiveness and improved beam focusing to advance cancer therapy

(2011) Christopher Allen et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Track structures, DNA targets and radiation effects in the biophysical Monte Carlo simulation code PARTRAC

(2011) Werner Friedland et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways

(2011) Emil Mladenov et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair

(2011) Deniz Simsek et al.   NATURE

DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair

(2011) Yankun Gao et al.   NATURE

Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair

(2011) Satyendra K. Singh et al.   NUCLEIC ACIDS RESEARCH

Targeting DNA damage and repair: Embracing the pharmacological era for successful cancer therapy

(2011) K. Aziz et al.   PHARMACOLOGY & THERAPEUTICS

The role of homologous recombination in radiation-induced double-strand break repair

(2011) Penny A. Jeggo et al.   RADIOTHERAPY AND ONCOLOGY

Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair

(2011) Michael Weinfeld et al.   TRENDS IN BIOCHEMICAL SCIENCES

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

(2011) Deniz Simsek et al.   PLoS Genetics

Heterochromatin maintenance and establishment: Lessons from the mouse pericentromere

(2011) Geneviève Almouzni et al.   Nucleus

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

Small scale genetic alterations contribute to increased mutability at the X-linked Hprt locus in vivo in Blm hypomorphic mice

(2010) Irina V. Tereshchenko et al.   DNA REPAIR

High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

(2010) Jason S Iacovoni et al.   EMBO JOURNAL

Widespread Dependence of Backup NHEJ on Growth State: Ramifications for the Use of DNA-PK Inhibitors

(2010) Satyendra K. Singh et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Distinct Roles of Ape1 Protein in the Repair of DNA Damage Induced by Ionizing Radiation or Bleomycin

(2010) Hua Fung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variation in base excision repair capacity

(2010) David M. Wilson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Chromatin dynamics during cell cycle mediate conversion of DNA damage into chromatid breaks and affect formation of chromosomal aberrations: Biological and clinical significance

(2010) Georgia I. Terzoudi et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Clustered DNA lesion repair in eukaryotes: Relevance to mutagenesis and cell survival

(2010) Evelyne Sage et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Double Holliday junctions are intermediates of DNA break repair

(2010) Malgorzata Bzymek et al.   NATURE

NHEJ and its backup pathways in chromosomal translocations

(2010) Michael R Lieber   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation

(2010) H. Wang et al.   NUCLEIC ACIDS RESEARCH

Stochastic Simulation of DNA Double-Strand Break Repair by Non-homologous End Joining Based on Track Structure Calculations

(2010) Werner Friedland et al.   RADIATION RESEARCH

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

(2009) Andrea Beucher et al.   EMBO JOURNAL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Charged particles in radiation oncology

(2009) Marco Durante et al.   Nature Reviews Clinical Oncology

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

(2009) Emilie Rass et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells

(2009) Shay Covo et al.   NUCLEIC ACIDS RESEARCH

Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage

(2009) Laura J. Eccles et al.   NUCLEIC ACIDS RESEARCH

Extensive Repair of DNA Double-Strand Breaks in Cells Deficient in the DNA-PK-Dependent Pathway of NHEJ after Exclusion of Heat-Labile Sites

(2009) Satyendra K. Singh et al.   RADIATION RESEARCH

Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence

(2009) George Iliakis   RADIOTHERAPY AND ONCOLOGY

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Up-regulation of WRN and DNA ligase III  in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks

(2008) A. Sallmyr et al.   BLOOD

The endless tale of non-homologous end-joining

(2008) Eric Weterings et al.   CELL RESEARCH

Interplay of two major repair pathways in the processing of complex double-strand DNA breaks

(2008) Tracey A. Dobbs et al.   DNA REPAIR

Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2

(2008) Wenqi Wu et al.   DNA REPAIR

Mappingin VivoChromatin Interactions in Yeast Suggests an Extended Chromatin Fiber with Regional Variation in Compaction

(2008) Job Dekker   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA repair of clustered lesions in mammalian cells: involvement of non-homologous end-joining

(2008) S. Malyarchuk et al.   NUCLEIC ACIDS RESEARCH

Histone H1 functions as a stimulatory factor in backup pathways of NHEJ

(2008) B. Rosidi et al.   NUCLEIC ACIDS RESEARCH

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH

Analysis of cryo-electron microscopy images does not support the existence of 30-nm chromatin fibers in mitotic chromosomes in situ

(2008) M. Eltsov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced Use of Backup Pathways of NHEJ in G2in Chinese Hamster Mutant Cells with Defects in the Classical Pathway of NHEJ

(2008) Wenqi Wu et al.   RADIATION RESEARCH

Biophysical Modeling of Fragment Length Distributions of DNA Plasmids after X and Heavy-Ion Irradiation Analyzed by Atomic Force Microscopy

(2008) Thilo Elsässer et al.   RADIATION RESEARCH

Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions

(2008) E. Soutoglou et al.   SCIENCE

MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings

(2008) Mitch McVey et al.   TRENDS IN GENETICS

Processing of DNA damage clusters in human cells: current status of knowledge

(2007) Alexandros G. Georgakilas   Molecular BioSystems