Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission

Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages

(2019) Dogukan Mizrak et al.   Cell Reports

Continuum of Gene-Expression Profiles Provides Spatial Division of Labor within a Differentiated Cell Type

(2019) Miri Adler et al.   Cell Systems

The Hypothalamic Arcuate Nucleus-Median Eminence is a Target for Sustained Diabetes Remission Induced by Fibroblast Growth Factor 1

(2019) Jenny M. Brown et al.   DIABETES

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

(2019) Luca A. Lotta et al.   CELL

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

Central and Peripheral Administration of Fibroblast Growth Factor 1 Improves Pancreatic Islet Insulin Secretion in Diabetic Mouse Models

(2019) Katherine G. Tennant et al.   DIABETES

Characterization of endogenous players in Fibroblast Growth Factor‐regulated functions of hypothalamic tanycytes and energy‐balance nuclei

(2019) Benediktas Kaminskas et al.   JOURNAL OF NEUROENDOCRINOLOGY

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

(2019) Jason Flannick et al.   NATURE

Rethinking the role of the brain in glucose homeostasis and diabetes pathogenesis

(2019) Jenny M. Brown et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuronal vulnerability and multilineage diversity in multiple sclerosis

(2019) Lucas Schirmer et al.   NATURE

Long-Term Plasticity of Neurotransmitter Release: Emerging Mechanisms and Contributions to Brain Function and Disease

(2018) Hannah R. Monday et al.   Annual Review of Neuroscience

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Accumulation of Dense Core Vesicles in Hippocampal Synapses Following Chronic Inactivity

(2018) Chang-Lu Tao et al.   Frontiers in Neuroanatomy

Genetic identification of leptin neural circuits in energy and glucose homeostases

(2018) Jie Xu et al.   NATURE

Important Shapeshifter: Mechanisms Allowing Astrocytes to Respond to the Changing Nervous System During Development, Injury and Disease

(2018) Juliane Schiweck et al.   Frontiers in Cellular Neuroscience

Revisiting How the Brain Senses Glucose—And Why

(2018) Marie Aare Bentsen et al.   Cell Metabolism

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

(2018) Cristina García-Cáceres et al.   NATURE NEUROSCIENCE

Reversed graph embedding resolves complex single-cell trajectories

(2017) Xiaojie Qiu et al.   NATURE METHODS

A molecular census of arcuate hypothalamus and median eminence cell types

(2017) John N Campbell et al.   NATURE NEUROSCIENCE

The Reactome Pathway Knowledgebase

(2017) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

(2017) Philip Hasel et al.   Nature Communications

Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity

(2017) Renchao Chen et al.   Cell Reports

Recent Advances in the Cellular and Molecular Mechanisms of Hypothalamic Neuronal Glucose Detection

(2017) Xavier Fioramonti et al.   Frontiers in Physiology

Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin

(2016) Sandeep K. Singh et al.   CELL

Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents

(2016) Jarrad M Scarlett et al.   NATURE MEDICINE

Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes

(2016) Roman A Romanov et al.   NATURE NEUROSCIENCE

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

The role of tanycytes in hypothalamic glucosensing

(2015) Roberto Elizondo-Vega et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Brain-derived neurotrophic factor is required for axonal growth of selective groups of neurons in the arcuate nucleus

(2015) Guey-Ying Liao et al.   Molecular Metabolism

The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis

(2015) Aykut Üner et al.   Molecular Metabolism

Activity-Dependent Structural Plasticity of Perisynaptic Astrocytic Domains Promotes Excitatory Synapse Stability

(2014) Yann Bernardinelli et al.   CURRENT BIOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

(2012) Daniel A Lee et al.   NATURE NEUROSCIENCE

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

ATP-mediated glucosensing by hypothalamic tanycytes

(2011) Cameron Frayling et al.   JOURNAL OF PHYSIOLOGY-LONDON

Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3

(2011) L Sha et al.   MOLECULAR PSYCHIATRY

Rank–rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures

(2010) Seema B. Plaisier et al.   NUCLEIC ACIDS RESEARCH

Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity

(2010) T. L. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Binding of Integrin αvβ3 to FGF1 Plays a Role in FGF1 Signaling

(2008) Seiji Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

(2008) A. C. Barbosa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA