Gene Therapy Applications of Non-Human Lentiviral Vectors

TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner

(2020) Molly Ohainle et al.   PLoS Pathogens

Lentiviral Vectors for the Treatment and Prevention of Cystic Fibrosis Lung Disease

(2019) Laura Marquez Loza et al.   Genes

Clinical use of lentiviral vectors

(2018) Michael C. Milone et al.   LEUKEMIA

Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hosts

(2018) Sarah A. Mereby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue

(2018) Dorota Kmiec et al.   PLoS Pathogens

Tropism, intracerebral distribution, and transduction efficiency of HIV- and SIV-based lentiviral vectors after injection into the mouse brain: a qualitative and quantitative in vivo study

(2017) Juraj Hlavatý et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Lentiviral Vector Gene Transfer of Endostatin/Angiostatin for Macular Degeneration (GEM) Study

(2017) Peter A. Campochiaro et al.   HUMAN GENE THERAPY

Insights into the molecular and biological features of the dUTPase-related gene of bovine immunodeficiency virus

(2017) Yulia Podolny et al.   VIROLOGY

The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild

(2016) Anke Heigele et al.   Cell Host & Microbe

S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3

(2016) Ajit Chande et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lentiviral vectors, two decades later

(2016) L. Naldini et al.   SCIENCE

Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis

(2016) Eric W F W Alton et al.   THORAX

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef

(2015) Yoshiko Usami et al.   NATURE

HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation

(2015) Annachiara Rosa et al.   NATURE

dUTPase: the frequently overlooked enzyme encoded by many retroviruses

(2015) Amnon Hizi et al.   Retrovirology

Lv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to Integration

(2015) Massimo Pizzato et al.   PLoS Pathogens

Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial

(2014) Stéphane Palfi et al.   LANCET

Discovery and full genome characterization of two highly divergent simian immunodeficiency viruses infecting black-and-white colobus monkeys (Colobus guereza) in Kibale National Park, Uganda

(2013) Michael Lauck et al.   Retrovirology

Intrapulmonary Versus Nasal Transduction of Murine Airways With GP64-pseudotyped Viral Vectors

(2013) Mayumi Oakland et al.   Molecular Therapy-Nucleic Acids

Cross-species transmission of simian retroviruses

(2012) Sabrina Locatelli et al.   AIDS

The Ability of Primate Lentiviruses to Degrade the Monocyte Restriction Factor SAMHD1 Preceded the Birth of the Viral Accessory Protein Vpx

(2012) Efrem S. Lim et al.   Cell Host & Microbe

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

The Determination of Importance of Sequences Neighboring the Psi Sequence in Lentiviral Vector Transduction and Packaging Efficiency

(2012) Seon Hee Kim et al.   PLoS One

Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines

(2012) Donatella RM Negri et al.   Retrovirology

Clinical Aspects of Feline Retroviruses: A Review

(2012) Katrin Hartmann   Viruses-Basel

Lentiviral Vector Gene Transfer to Porcine Airways

(2012) Patrick L Sinn et al.   Molecular Therapy-Nucleic Acids

Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection

(2011) A. Biffi et al.   BLOOD

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Viral evolution in deep time: lentiviruses and mammals

(2011) Robert J. Gifford   TRENDS IN GENETICS

Toward Gene Therapy for Cystic Fibrosis Using a Lentivirus Pseudotyped With Sendai Virus Envelopes

(2010) Katsuyuki Mitomo et al.   MOLECULAR THERAPY

Where the Wild Things Are: Pathogenesis of SIV Infection in African Nonhuman Primate Hosts

(2010) Ivona Pandrea et al.   Current HIV/AIDS Reports

Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells

(2009) Y.-J. Kim et al.   BLOOD

Development of inducible EIAV-based lentiviral vector packaging and producer cell lines

(2009) H J Stewart et al.   GENE THERAPY

Stable Retinal Gene Expression in Nonhuman Primates via Subretinal Injection of SIVagm-Based Lentiviral Vectors

(2009) Yasuhiro Ikeda et al.   HUMAN GENE THERAPY

Prolonged Transgene Expression with Lentiviral Vectors in the Aqueous Humor Outflow Pathway of Nonhuman Primates

(2009) Román A. Barraza et al.   HUMAN GENE THERAPY

Extensive survey on the prevalence and genetic diversity of SIVs in primate bushmeat provides insights into risks for potential new cross-species transmissions

(2009) Avelin F. Aghokeng et al.   INFECTION GENETICS AND EVOLUTION

Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2

(2009) Bin Jia et al.   PLoS Pathogens

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

Tissue-specific restriction of cyclophilin A-independent HIV-1- and SIV-derived lentiviral vectors

(2008) C A Kahl et al.   GENE THERAPY

SIVMAC Vpx improves the transduction of dendritic cells with nonintegrative HIV-1-derived vectors

(2008) G Berger et al.   GENE THERAPY

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

(2008) Salima Hacein-Bey-Abina et al.   JOURNAL OF CLINICAL INVESTIGATION

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

Primate Lentiviral Vpx Commandeers DDB1 to Counteract a Macrophage Restriction

(2008) Natalia Sharova et al.   PLoS Pathogens

Durable, Safe, Multi-gene Lentiviral Vector Expression in Feline Trabecular Meshwork

(2007) Pranay D Khare et al.   MOLECULAR THERAPY