Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

Integrase-defective lentiviral-vector-based vaccine: a new vector for induction of T cell immunity

(2011) Donatella RM Negri et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Corticospinal tract transduction: a comparison of seven adeno-associated viral vector serotypes and a non-integrating lentiviral vector

(2011) T H Hutson et al.   GENE THERAPY

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

(2011) Janka Mátrai et al.   HEPATOLOGY

Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection

(2011) Rikke Olesen et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

One Percent Tenofovir Applied Topically to Humanized BLT Mice and Used According to the CAPRISA 004 Experimental Design Demonstrates Partial Protection from Vaginal HIV Infection, Validating the BLT Model for Evaluation of New Microbicide Candidates

(2011) P. W. Denton et al.   JOURNAL OF VIROLOGY

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

A simple, versatile and efficient method to genetically modify human monocyte-derived dendritic cells with HIV-1–derived lentiviral vectors

(2011) Grégory Berger et al.   Nature Protocols

Toward Integrase Defective Lentiviral Vectors for Genetic Immunization

(2010) Donatella R.M. Negri et al.   CURRENT HIV RESEARCH

Transduction of Human Antigen-Presenting Cells with Integrase-Defective Lentiviral Vector Enables Functional Expansion of Primed Antigen-Specific CD8+ T Cells

(2010) Donatella R.M. Negri et al.   HUMAN GENE THERAPY

Immunization delivered by lentiviral vectors for cancer and infectious diseases

(2010) Biliang Hu et al.   IMMUNOLOGICAL REVIEWS

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

Vaccines delivered by integration-deficient lentiviral vectors targeting dendritic cells induces strong antigen-specific immunity

(2010) Biliang Hu et al.   VACCINE

Persistence of mucosal and systemic immune responses following sublingual immunization

(2010) Donatella R.M. Negri et al.   VACCINE

Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors

(2009) A A Rahim et al.   GENE THERAPY

Integrase-defective lentiviral vectors: progress and applications

(2009) M B Banasik et al.   GENE THERAPY

Nonintegrating Lentivector Vaccines Stimulate Prolonged T-Cell and Antibody Responses and Are Effective in Tumor Therapy

(2009) K. Karwacz et al.   JOURNAL OF VIROLOGY

Integration-deficient Lentiviral Vectors: A Slow Coming of Age

(2009) Klaus Wanisch et al.   MOLECULAR THERAPY

Development and use of SIV-based Integrase defective lentiviral vector for immunization

(2009) Zuleika Michelini et al.   VACCINE

SIVMAC Vpx improves the transduction of dendritic cells with nonintegrative HIV-1-derived vectors

(2008) G Berger et al.   GENE THERAPY

Protective Antiviral Immunity Conferred by a Nonintegrative Lentiviral Vector-Based Vaccine

(2008) Frédéric Coutant et al.   PLoS One

Antiretroviral Pre-exposure Prophylaxis Prevents Vaginal Transmission of HIV-1 in Humanized BLT Mice

(2008) Paul W Denton et al.   PLOS MEDICINE