GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia

PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel

(2019) Junhua Yang et al.   SCIENCE

GPR68 Senses Flow and Is Essential for Vascular Physiology

(2018) Jie Xu et al.   CELL

Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a

(2018) Yuanyuan Xu et al.   FASEB JOURNAL

CNS distribution, signalling properties and central effects of G-protein coupled receptor 4

(2018) P.S. Hosford et al.   NEUROPHARMACOLOGY

Microglial Acid Sensing Regulates Carbon Dioxide-Evoked Fear

(2016) Lauren Larke Vollmer et al.   BIOLOGICAL PSYCHIATRY

Region specific contribution of ASIC2 to acidosis-and ischemia-induced neuronal injury

(2016) Nan Jiang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

OGR1/GPR68 Modulates the Severity of Experimental Autoimmune Encephalomyelitis and Regulates Nitric Oxide Production by Macrophages

(2016) Cheryl A. D’Souza et al.   PLoS One

Two aspects of ASIC function: Synaptic plasticity and neuronal injury

(2015) Yan Huang et al.   NEUROPHARMACOLOGY

Biophysical properties of acid-sensing ion channels (ASICs)

(2015) Stefan Gründer et al.   NEUROPHARMACOLOGY

Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+and H+

(2015) Wei-Chun Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons

(2015) N. N. Kumar et al.   SCIENCE

Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction

(2015) Yi-Zhi Wang et al.   eLife

Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity

(2014) Collin J Kreple et al.   NATURE NEUROSCIENCE

Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala

(2014) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of inflammation by extracellular acidification and proton-sensing GPCRs

(2013) Fumikazu Okajima   CELLULAR SIGNALLING

Loss of Acid Sensing Ion Channel-1a and Bicarbonate Administration Attenuate the Severity of Traumatic Brain Injury

(2013) Terry Yin et al.   PLoS One

Acid-sensing ion channels: trafficking and synaptic function

(2013) Xiang-ming Zha   Molecular Brain

Assessing Post-Stroke Behavior in Mouse Models of Focal Ischemia

(2012) Mustafa Balkaya et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Dynorphin Opioid Peptides Enhance Acid-Sensing Ion Channel 1a Activity and Acidosis-Induced Neuronal Death

(2009) T. W. Sherwood et al.   JOURNAL OF NEUROSCIENCE

Abnormalities in Osteoclastogenesis and Decreased Tumorigenesis in Mice Deficient for Ovarian Cancer G Protein-Coupled Receptor 1

(2009) Hui Li et al.   PLoS One

Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice

(2008) Ertugrul Kilic et al.   JOURNAL OF PINEAL RESEARCH