Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons

Phox2b-Expressing Retrotrapezoid Neurons Are Intrinsically Responsive to H+ and CO2

(2013) S. Wang et al.   JOURNAL OF NEUROSCIENCE

TASK-2 Channels Contribute to pH Sensitivity of Retrotrapezoid Nucleus Chemoreceptor Neurons

(2013) S. Wang et al.   JOURNAL OF NEUROSCIENCE

Selective Optogenetic Activation of Rostral Ventrolateral Medullary Catecholaminergic Neurons Produces Cardiorespiratory Stimulation in Conscious Mice

(2013) S. B. G. Abbott et al.   JOURNAL OF NEUROSCIENCE

Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis

(2013) Lixue Dong et al.   PLoS One

The physiological determinants of Sudden Infant Death Syndrome

(2013) Alfredo J. Garcia et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Respiratory and behavioral dysfunction following loss of the GABAA receptor α4 subunit

(2013) C. Jean Loria et al.   Brain and Behavior

Development of the serotonergic cells in murine raphe nuclei and their relations with rhombomeric domains

(2012) Antonia Alonso et al.   Brain Structure & Function

The Proton-activated G Protein Coupled Receptor OGR1 Acutely Regulates the Activity of Epithelial Proton Transport Proteins

(2012) Nilufar Mohebbi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor

(2011) Lorenza Wyder et al.   ANGIOGENESIS

Induction of Metabolic Acidosis with Ammonium Chloride (NH4Cl) in Mice and Rats – Species Differences and Technical Considerations

(2011) Marta Nowik et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Breathing without CO2 Chemosensitivity in Conditional Phox2b Mutants

(2011) N. Ramanantsoa et al.   JOURNAL OF NEUROSCIENCE

Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway

(2011) Aishe Chen et al.   PLoS One

An Official ATS Clinical Policy Statement: Congenital Central Hypoventilation Syndrome

(2010) Debra E. Weese-Mayer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Central respiratory chemoreception

(2010) Patrice G. Guyenet et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Astrocytes in the Retrotrapezoid Nucleus Sense H+ by Inhibition of a Kir4.1–Kir5.1-Like Current and May Contribute to Chemoreception by a Purinergic Mechanism

(2010) Ian C. Wenker et al.   JOURNAL OF NEUROPHYSIOLOGY

Motoneuronal TASK Channels Contribute to Immobilizing Effects of Inhalational General Anesthetics

(2010) R. M. Lazarenko et al.   JOURNAL OF NEUROSCIENCE

Deletion of the pH Sensor GPR4 Decreases Renal Acid Excretion

(2010) X. Sun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Task2 potassium channels set central respiratory CO2 and O2 sensitivity

(2010) C. Gestreau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes Control Breathing Through pH-Dependent Release of ATP

(2010) A. V. Gourine et al.   SCIENCE

Acid sensitivity and ultrastructure of the retrotrapezoid nucleus in Phox2b-EGFP transgenic mice

(2009) Roman M. Lazarenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Photostimulation of Retrotrapezoid Nucleus Phox2b-Expressing Neurons In Vivo Produces Long-Lasting Activation of Breathing in Rats

(2009) S. B. G. Abbott et al.   JOURNAL OF NEUROSCIENCE

Activation of the retrotrapezoid nucleus by posterior hypothalamic stimulation

(2009) Michal G. Fortuna et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ondansetron and fluoxetine reduce sleep apnea in mice lacking monoamine oxidase A

(2009) C. Real et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons

(2008) V. Dubreuil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous central apneas occur in the C57BL/6J mouse strain

(2007) Georg M. Stettner et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY