Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase

Progress and Challenges in Aminoacyl-tRNA Synthetase-based Therapeutics

(2019) Christopher S. Francklyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

(2019) Beatriz Baragaña et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection

(2019) Frederick S. Buckner et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors

(2019) Rajiv S. Jumani et al.   Nature Communications

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

(2019) Christopher S. Lunde et al.   Nature Communications

Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection

(2019) Christopher Swale et al.   Science Translational Medicine

A Novel Piperazine-Based Drug Lead for Cryptosporidiosis from the Medicines for Malaria Venture Open-Access Malaria Box

(2018) R. S. Jumani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis

(2018) Sangun Lee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Epidemiology and Risk Factors for Cryptosporidiosis in Children From 8 Low-income Sites: Results From the MAL-ED Study

(2018) Poonum S Korpe et al.   CLINICAL INFECTIOUS DISEASES

Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum

(2018) Yogavel Manickam et al.   DRUG DISCOVERY TODAY

The Existing Drug Vorinostat as a New Lead Against Cryptosporidiosis by Targeting the Parasite Histone Deacetylases

(2018) Fengguang Guo et al.   JOURNAL OF INFECTIOUS DISEASES

Chemical probes and drug leads from advances in synthetic planning and methodology

(2018) Christopher J. Gerry et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model

(2018) Erin Stebbins et al.   PLoS Neglected Tropical Diseases

Morbidity, mortality, and long-term consequences associated with diarrhoea from Cryptosporidium infection in children younger than 5 years: a meta-analyses study

(2018) Ibrahim A Khalil et al.   Lancet Global Health

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Christopher Troeger et al.   LANCET INFECTIOUS DISEASES

Evaluation of 4-amino 2-anilinoquinazolines against Plasmodium and other apicomplexan parasites in vitro and in a P. falciparum humanized NOD-scid IL2Rγnull mouse model of malaria

(2018) Paul R. Gilson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis

(2018) Jeff Janes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection

(2017) Samuel L. M. Arnold et al.   JOURNAL OF INFECTIOUS DISEASES

Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp3)–H Arylation

(2017) Micah Maetani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis

(2017) Ujjini H. Manjunatha et al.   NATURE

Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis

(2017) Vitul Jain et al.   STRUCTURE

Cryptosporidium spp. Infection in Solid Organ Transplantation

(2017) Fanny Lanternier et al.   TRANSPLANTATION

Repurposing of Potent Drug Candidates for Multiparasite Targeting

(2017) Vitul Jain et al.   TRENDS IN PARASITOLOGY

A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis

(2017) Melissa S. Love et al.   PLoS Neglected Tropical Diseases

Structure-Based Targeting of Orthologous Pathogen Proteins Accelerates Antiparasitic Drug Discovery

(2017) Vitul Jain et al.   ACS Infectious Diseases

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase

(2016) Andrés Palencia et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals

(2016) Li Liu et al.   LANCET

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

(2016) Nobutaka Kato et al.   NATURE

Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis

(2016) Arvind Sharma et al.   PLoS Neglected Tropical Diseases

Cryptosporidiosis Drug Discovery: Opportunities and Challenges

(2016) Ujjini H. Manjunatha et al.   ACS Infectious Diseases

Inhibition of Protein Synthesis and Malaria Parasite Development by Drug Targeting of Methionyl-tRNA Synthetases

(2015) Tahir Hussain et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Plasmodium falciparummitochondria import tRNAs along with an active phenylalanyl-tRNA synthetase

(2015) Arvind Sharma et al.   BIOCHEMICAL JOURNAL

A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

(2015) William Checkley et al.   LANCET INFECTIOUS DISEASES

Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum

(2015) Sumiti Vinayak et al.   NATURE

A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments

(2015) Christopher D. Huston et al.   PLoS Neglected Tropical Diseases

Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED)

(2015) James A Platts-Mills et al.   Lancet Global Health

Identification of Cryptosporidium parvum Active Chemical Series by Repurposing the Open Access Malaria Box

(2014) K. Bessoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Drug Repurposing Screen Reveals FDA-Approved Inhibitors of Human HMG-CoA Reductase and Isoprenoid Synthesis That Block Cryptosporidium parvum Growth

(2013) Kovi Bessoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Amelioration of Cryptosporidium parvum Infection In Vitro and In Vivo by Targeting Parasite Fatty Acyl-Coenzyme A Synthetases

(2013) F. Guo et al.   JOURNAL OF INFECTIOUS DISEASES

A Novel Calcium-Dependent Protein Kinase Inhibitor as a Lead Compound for Treating Cryptosporidiosis

(2013) Alejandro Castellanos-Gonzalez et al.   JOURNAL OF INFECTIOUS DISEASES

Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

(2013) Karen L Kotloff et al.   LANCET

Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold

(2013) Zhongsheng Zhang et al.   ACS Medicinal Chemistry Letters

Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites

(2013) James S. Pham et al.   International Journal for Parasitology-Drugs and Drug Resistance

Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries

(2012) Jason T. Lowe et al.   JOURNAL OF ORGANIC CHEMISTRY

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

(2012) Tracy L Keller et al.   Nature Chemical Biology

Contribution of Enteric Infection, Altered Intestinal Barrier Function, and Maternal Malnutrition to Infant Malnutrition in Bangladesh

(2011) D. Mondal et al.   CLINICAL INFECTIOUS DISEASES

N-Heterocyclic Carbene Catalyzed Transformations of 3-Halopropenals to the Equivalents of β-Acylvinyl Anions

(2010) Yihua Wu et al.   ORGANIC LETTERS

High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: a randomised controlled trial

(2009) Beatrice Amadi et al.   BMC INFECTIOUS DISEASES

Towards the Optimal Screening Collection: A Synthesis Strategy

(2007) Thomas E. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION