The purinergic receptor P2Y11 choreographs the polarization, mitochondrial metabolism, and migration of T lymphocytes

Lipopolysaccharide suppresses T cells by generating extracellular ATP that impairs their mito-chondrial function via P2Y11 receptors

(2019) Koichiro Sueyoshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purinergic P2Y2 receptors modulate endothelial sprouting

(2019) Severin Mühleder et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Adenosine Metabolism: Emerging Concepts for Cancer Therapy

(2019) Detlev Boison et al.   CANCER CELL

Adenosine metabolism, immunity and joint health

(2018) György Haskó et al.   BIOCHEMICAL PHARMACOLOGY

ATP Release Channels

(2018) Akiyuki Taruno   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human P2Y11 Expression Level Affects Human P2X7 Receptor-Mediated Cell Death

(2018) Karin Dreisig et al.   Frontiers in Immunology

Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration

(2018) Carola Ledderose et al.   JOURNAL OF CLINICAL INVESTIGATION

The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells

(2018) Henrique Borges da Silva et al.   NATURE

Plasma Adenylate Levels are Elevated in Cardiopulmonary Arrest Patients and May Predict Mortality

(2018) Yuka Sumi et al.   SHOCK

T Cell–Inflamed versus Non-T Cell–Inflamed Tumors: A Conceptual Framework for Cancer Immunotherapy Drug Development and Combination Therapy Selection

(2018) Jonathan A. Trujillo et al.   Cancer Immunology Research

Inhibitory effect of extracellular purine nucleotide and nucleoside concentrations on T cell proliferation

(2016) Monica Weiler et al.   EXPERIMENTAL CELL RESEARCH

Pannexin1 Channels Are Required for Chemokine-Mediated Migration of CD4+T Lymphocytes: Role in Inflammation and Experimental Autoimmune Encephalomyelitis

(2016) Stephani Velasquez et al.   JOURNAL OF IMMUNOLOGY

Odorants specifically modulate chemotaxis and tissue retention of CD4+ T cells via cyclic adenosine monophosphate induction

(2016) Adam A. Clark et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A critical look at the function of the P2Y11 receptor

(2016) Karin Dreisig et al.   Purinergic Signalling

Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells – Role of Anchored Protein Kinase A Signaling Units

(2016) Vanessa L. Wehbi et al.   Frontiers in Immunology

Purinergic signaling in the immune system

(2015) Francesco Di Virgilio et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis

(2015) Yi Bao et al.   JOURNAL OF CELL BIOLOGY

Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells

(2014) C. M. Wang et al.   EMBO JOURNAL

Mitochondria Are Gate-keepers of T Cell Function by Producing the ATP That Drives Purinergic Signaling

(2014) Carola Ledderose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleotide signalling during inflammation

(2014) Marco Idzko et al.   NATURE

Purinergic signalling and immune cells

(2014) Geoffrey Burnstock et al.   Purinergic Signalling

Investigation of the Inhibitory Effects of the Benzodiazepine Derivative, 5-BDBD on P2X4Purinergic Receptors by two Complementary Methods

(2013) Bernadett Balázs et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Pannexin 1 Channels Link Chemoattractant Receptor Signaling to Local Excitation and Global Inhibition Responses at the Front and Back of Polarized Neutrophils

(2013) Yi Bao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autocrine Regulation of Macrophage Activation via Exocytosis of ATP and Activation of P2Y11 Receptor

(2013) Hayato Sakaki et al.   PLoS One

Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic

(2013) Fang Han et al.   PLoS Genetics

Role of Mitochondrial Ca2+ in the Regulation of Cellular Energetics

(2012) Brian Glancy et al.   BIOCHEMISTRY

ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation

(2012) Monali Manohar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Vesicular and conductive mechanisms of nucleotide release

(2012) Eduardo R. Lazarowski   Purinergic Signalling

Mitochondrial ROS production under cellular stress: comparison of different detection methods

(2011) Andrey V. Kuznetsov et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse

(2011) Francesc Baixauli et al.   EMBO JOURNAL

Activation and Regulation of Purinergic P2X Receptor Channels

(2011) C. Coddou et al.   PHARMACOLOGICAL REVIEWS

ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

(2011) U. Schenk et al.   Science Signaling

A Comparison of Mathematical Models for Polarization of Single Eukaryotic Cells in Response to Guided Cues

(2011) Alexandra Jilkine et al.   PLoS Computational Biology

Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse

(2010) T. Woehrle et al.   BLOOD

Cyclic AMP-mediated immune regulation — Overview of mechanisms of action in T cells

(2010) Randi Mosenden et al.   CELLULAR SIGNALLING

mTORC2 Regulates Neutrophil Chemotaxis in a cAMP- and RhoA-Dependent Fashion

(2010) Lunhua Liu et al.   DEVELOPMENTAL CELL

Common variants in P2RY11 are associated with narcolepsy

(2010) Birgitte R Kornum et al.   NATURE GENETICS

Actin Dynamics at the Leading Edge: From Simple Machinery to Complex Networks

(2009) Robert H. Insall et al.   DEVELOPMENTAL CELL

Autocrine regulation of T-cell activation by ATP release and P2X7 receptors

(2009) Linda Yip et al.   FASEB JOURNAL

NF546 [4,4'-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene- , '-diphosphonic Acid) Tetrasodium Salt] Is a Non-Nucleotide P2Y11 Agonist and Stimulates Release of Interleukin-8 from Human Monocyte-Derived Dendritic Cells

(2009) S. Meis et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Choreography of Cell Motility and Interaction Dynamics Imaged by Two-Photon Microscopy in Lymphoid Organs

(2008) Michael D. Cahalan et al.   Annual Review of Immunology

Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels

(2008) U. Schenk et al.   Science Signaling