The rice NLR pair Pikp-1/Pikp-2 initiates cell death through receptor cooperation rather than negative regulation

A Plant Immune Receptor Adopts a Two-Step Recognition Mechanism to Enhance Viral Effector Perception

(2019) Jia Li et al.   Molecular Plant

Animal NLRs continue to inform plant NLR structure and function

(2019) Hayden Burdett et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Reconstitution and structure of a plant NLR resistosome conferring immunity

(2019) Jizong Wang et al.   SCIENCE

Ligand-triggered allosteric ADP release primes a plant NLR complex

(2019) Jizong Wang et al.   SCIENCE

The Plant “Resistosome”: Structural Insights into Immune Signaling

(2019) Hayden Burdett et al.   Cell Host & Microbe

Help wanted: helper NLRs and plant immune responses

(2019) Lance M Jubic et al.   CURRENT OPINION IN PLANT BIOLOGY

NLR singletons, pairs, and networks: evolution, assembly, and regulation of the intracellular immunoreceptor circuitry of plants

(2019) Hiroaki Adachi et al.   CURRENT OPINION IN PLANT BIOLOGY

Structural and biochemical studies of an NB-ARC domain from a plant NLR immune receptor

(2019) John F. C. Steele et al.   PLoS One

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

(2019) Li Wan et al.   SCIENCE

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

(2019) Shane Horsefield et al.   SCIENCE

TIR Domain Proteins Are an Ancient Family of NAD + -Consuming Enzymes

(2018) Kow Essuman et al.   CURRENT BIOLOGY

Microbial effectors and the role of water and sugar in the infection battle ground

(2018) Farid El Kasmi et al.   CURRENT OPINION IN PLANT BIOLOGY

Defended to the Nines: 25 Years of Resistance Gene Cloning Identifies Nine Mechanisms for R Protein Function

(2018) Jiorgos Kourelis et al.   PLANT CELL

The intracellular nucleotide-binding leucine-rich repeat receptor (SlNRC4a) enhances immune signalling elicited by extracellular perception

(2018) Meirav Leibman-Markus et al.   PLANT CELL AND ENVIRONMENT

Receptor networks underpin plant immunity

(2018) Chih-Hang Wu et al.   SCIENCE

Distinct modes of derepression of an Arabidopsis immune receptor complex by two different bacterial effectors

(2018) Yan Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential regulation of TNL-mediated immune signaling by redundant helper CNLs

(2018) Zhongshou Wu et al.   NEW PHYTOLOGIST

Diverse NLR immune receptors activate defence via the RPW8-NLR NRG1

(2018) Baptiste Castel et al.   NEW PHYTOLOGIST

Specific recognition of two MAX effectors by integrated HMA domains in plant immune receptors involves distinct binding surfaces

(2018) Liwei Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide functional analyses of plant coiled–coil NLR-type pathogen receptors reveal essential roles of their N-terminal domain in oligomerization, networking, and immunity

(2018) Tadeusz Wróblewski et al.   PLOS BIOLOGY

The intracellular immune receptor Rx1 regulates the DNA-binding activity of a Golden2-like transcription factor

(2017) Philip D. Townsend et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recognition of the Magnaporthe oryzae Effector AVR-Pia by the Decoy Domain of the Rice NLR Immune Receptor RGA5

(2017) Diana Ortiz et al.   PLANT CELL

Analysis of the ZAR1 Immune Complex Reveals Determinants for Immunity and Molecular Interactions

(2017) Maël Baudin et al.   PLANT PHYSIOLOGY

Multiple functional self-association interfaces in plant TIR domains

(2017) Xiaoxiao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling from the plasma-membrane localized plant immune receptor RPM1 requires self-association of the full-length protein

(2017) Farid El Kasmi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLR network mediates immunity to diverse plant pathogens

(2017) Chih-Hang Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion

(2017) Jeannette L. Tenthorey et al.   SCIENCE

Protein-protein interactions in the RPS4/RRS1 immune receptor complex

(2017) Sung Un Huh et al.   PLoS Pathogens

Comparative analysis of plant immune receptor architectures uncovers host proteins likely targeted by pathogens

(2016) Panagiotis F. Sarris et al.   BMC BIOLOGY

Integration of decoy domains derived from protein targets of pathogen effectors into plant immune receptors is widespread

(2016) Thomas Kroj et al.   NEW PHYTOLOGIST

Comparative analysis of the flax immune receptors L6 and L7 suggests an equilibrium-based switch activation model

(2016) Maud Bernoux et al.   PLANT CELL

The Chloroplastic Protein THF1 Interacts with the Coiled-Coil Domain of the Disease Resistance Protein N′ and Regulates Light-Dependent Cell Death

(2016) Louis-Philippe Hamel et al.   PLANT PHYSIOLOGY

Cytosolic activation of cell death and stem rust resistance by cereal MLA-family CC–NLR proteins

(2016) Stella Cesari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-informed insights for NLR functioning in plant immunity

(2016) Octavina C.A. Sukarta et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Multiple Domain Associations within the Arabidopsis Immune Receptor RPP1 Regulate the Activation of Programmed Cell Death

(2016) Karl J. Schreiber et al.   PLoS Pathogens

The N-Terminal Domain of the Tomato Immune Protein Prf Contains Multiple Homotypic and Pto Kinase Interaction Sites

(2015) Isabel Marie-Luise Saur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

Structural and biochemical basis for induced self-propagation of NLRC4

(2015) Z. Hu et al.   SCIENCE

Molecular and Functional Analyses of a Maize Autoactive NB-LRR Protein Identify Precise Structural Requirements for Activity

(2015) Guan-Feng Wang et al.   PLoS Pathogens

The changing of the guard: the Pto/Prf receptor complex of tomato and pathogen recognition

(2014) Vardis Ntoukakis et al.   CURRENT OPINION IN PLANT BIOLOGY

The NB‐LRR proteins RGA4 and RGA5 interact functionally and physically to confer disease resistance

(2014) Stella Césari et al.   EMBO JOURNAL

Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor

(2014) S. J. Williams et al.   SCIENCE

A novel conserved mechanism for plant NLR protein pairs: the “integrated decoy” hypothesis

(2014) Stella Cesari et al.   Frontiers in Plant Science

Structural Determinants at the Interface of the ARC2 and Leucine-Rich Repeat Domains Control the Activation of the Plant Immune Receptors Rx1 and Gpa2

(2013) E. J. Slootweg et al.   PLANT PHYSIOLOGY

Genetic Requirements for Signaling from an Autoactive Plant NB-LRR Intracellular Innate Immune Receptor

(2013) Melinda Roberts et al.   PLoS Genetics

How to build a pathogen detector: structural basis of NB-LRR function

(2012) Frank LW Takken et al.   CURRENT OPINION IN PLANT BIOLOGY

Structure-Function Analysis of the Coiled-Coil and Leucine-Rich Repeat Domains of the RPS5 Disease Resistance Protein

(2012) D. Qi et al.   PLANT PHYSIOLOGY

Structure-Function Analysis of Barley NLR Immune Receptor MLA10 Reveals Its Cell Compartment Specific Activity in Cell Death and Disease Resistance

(2012) Shiwei Bai et al.   PLoS Pathogens

Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation

(2011) Maud Bernoux et al.   Cell Host & Microbe

Coiled-Coil Domain-Dependent Homodimerization of Intracellular Barley Immune Receptors Defines a Minimal Functional Module for Triggering Cell Death

(2011) Takaki Maekawa et al.   Cell Host & Microbe

An Autoactive Mutant of the M Flax Rust Resistance Protein Has a Preference for Binding ATP, Whereas Wild-Type M Protein Binds ADP

(2011) Simon J. Williams et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Plant intracellular innate immune receptor Resistance to Pseudomonas syringae pv. maculicola 1 (RPM1) is activated at, and functions on, the plasma membrane

(2011) Z. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expanded functions for a family of plant intracellular immune receptors beyond specific recognition of pathogen effectors

(2011) V. Bonardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of a Rac GTPase by the NLR Family Disease Resistance Protein Pit Plays a Critical Role in Rice Innate Immunity

(2010) Yoji Kawano et al.   Cell Host & Microbe

Plant immunity: towards an integrated view of plant–pathogen interactions

(2010) Peter N. Dodds et al.   NATURE REVIEWS GENETICS

Activation of an Arabidopsis Resistance Protein Is Specified by the in Planta Association of Its Leucine-Rich Repeat Domain with the Cognate Oomycete Effector

(2010) K. V. Krasileva et al.   PLANT CELL

Prf immune complexes of tomato are oligomeric and contain multiple Pto-like kinases that diversify effector recognition

(2009) Jose R. Gutierrez et al.   PLANT JOURNAL

Structure–function analysis of the NB-ARC domain of plant disease resistance proteins

(2008) Gerben van Ooijen et al.   JOURNAL OF EXPERIMENTAL BOTANY

The Coiled-Coil and Nucleotide Binding Domains of the Potato Rx Disease Resistance Protein Function in Pathogen Recognition and Signaling

(2008) G. J. Rairdan et al.   PLANT CELL

A One Pot, One Step, Precision Cloning Method with High Throughput Capability

(2008) Carola Engler et al.   PLoS One