Identification of New Targets and the Virtual Screening of Lignans against Alzheimer’s Disease

Lignans and Neolignans anti-tuberculosis identified by QSAR and Molecular Modeling

(2020) Mayara dos Santos Maia et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors

(2020) Ehab M. Gedawy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

CCL28‐induced CCR10/eNOS interaction in angiogenesis and skin wound healing

(2020) Zhenlong Chen et al.   FASEB JOURNAL

Association between COX‐2 and 15‐PGDH polymorphisms and SLE susceptibility

(2020) Mahnaz Sandoughi et al.   International Journal of Rheumatic Diseases

Role of iNOS in osteoarthritis: Pathological and therapeutic aspects

(2020) Nashrah Ahmad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid β-Associated Alzheimer's Disease in Mice

(2020) Konrad M. Ricke et al.   JOURNAL OF NEUROSCIENCE

In vivo COX-2 modulation and metabolite profiling of Pandanus tectorius leaves extracts

(2020) Crisfel R. del Mundo et al.   3 Biotech

Nicorandil ameliorates bleomycin-induced pulmonary fibrosis in rats through modulating eNOS, iNOS, TXNIP and HIF-1α levels

(2020) Mohammed O. Kseibati et al.   LIFE SCIENCES

Carboranyl Derivatives of Rofecoxib with Cytostatic Activity against Human Melanoma and Colon Cancer Cells

(2020) Antonio Buzharevski et al.   Scientific Reports

eNOS rs2070744 polymorphism might influence predisposition to hemorrhagic cerebral vascular diseases in East Asians: A meta‐analysis

(2020) Qiuling Wang et al.   Brain and Behavior

Increased inducible nitric oxide synthase (iNOS) expression in human myocardial infarction

(2019) Verena Wilmes et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Cardiac sodium-dependent glucose cotransporter 1 is a novel mediator of ischaemia/reperfusion injury

(2019) Zhao Li et al.   CARDIOVASCULAR RESEARCH

Efficacy and safety of selective COX-2 inhibitors for pain management after third molar removal: a meta-analysis of randomized clinical trials

(2019) Albert González-Barnadas et al.   Clinical Oral Investigations

Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase

(2019) Ehab D. AlFadly et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease

(2019) Ludmila P. Dolgacheva et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Cerebrovascular and Neurological Disorders: Protective Role of NRF2

(2019) Farzane Sivandzade et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Protein–Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity

(2019) Meng-Chen Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The iNOS Activity During an Immune Response Controls the CNS Pathology in Experimental Autoimmune Encephalomyelitis

(2019) Sandip Ashok Sonar et al.   Frontiers in Immunology

Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances

(2019) František Zálešák et al.   PHARMACOLOGICAL RESEARCH

Phosphodiesterase 5 inhibitors as novel agents for the treatment of Alzheimer’s disease

(2019) Li Liu et al.   BRAIN RESEARCH BULLETIN

A small molecule chaperone rescues the stability and activity of a cancer‐associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro

(2019) Emilia Strandback et al.   FEBS LETTERS

PDZ/PDZ interaction between PSD‐95 and nNOS neuronal proteins

(2019) Javier Murciano‐Calles et al.   JOURNAL OF MOLECULAR RECOGNITION

Variability within the human iNOS gene and Achilles tendon injuries: Evidence for a heterozygous advantage effect

(2019) Charlotte Brookes et al.   JOURNAL OF SCIENCE AND MEDICINE IN SPORT

Artemether Activation of AMPK/GSK3β(ser9)/Nrf2 Signaling Confers Neuroprotection towards β-Amyloid-Induced Neurotoxicity in 3xTg Alzheimer’s Mouse Model

(2019) Shuai Li et al.   Oxidative Medicine and Cellular Longevity

Dentate nNOS accounts for stress‐induced 5‐HT 1A receptor deficiency: Implication in anxiety behaviors

(2019) Li‐Juan Zhu et al.   CNS Neuroscience & Therapeutics

Quercetin protects the vascular endothelium against iron overload damages via ROS/ADMA/DDAHⅡ/eNOS/NO pathway

(2019) Xuepiao Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Phosphodiesterase inhibitors say NO to Alzheimer's disease

(2019) Seyed Mohammad Nabavi et al.   FOOD AND CHEMICAL TOXICOLOGY

Liraglutide ameliorates palmitate-induced oxidative injury in islet microvascular endothelial cells through GLP-1 receptor/PKA and GTPCH1/eNOS signaling pathways

(2019) Yunyi Le et al.   PEPTIDES

Phosphorylation and activation of endothelial nitric oxide synthase by red fruit (Pandanus conoideus Lam) oil and its fractions

(2019) Christian Schirra et al.   JOURNAL OF ETHNOPHARMACOLOGY

Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease

(2018) Martín Estrada Valencia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead

(2018) Devendra Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Prostaglandin D 2 generation from human lung mast cells is catalysed exclusively by cyclooxygenase-1

(2018) Bandar K. Baothman et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dissecting the Role of 5-Lipoxygenase in the Homocysteine-Induced Alzheimer’s Disease Pathology

(2018) Antonio Di Meco et al.   JOURNAL OF ALZHEIMERS DISEASE

Sub-efficacious doses of phosphodiesterase 4 and 5 inhibitors improve memory in a mouse model of Alzheimer's disease

(2018) Walter Gulisano et al.   NEUROPHARMACOLOGY

Pathology of nNOS-Expressing GABAergic Neurons in Mouse Model of Alzheimer’s Disease

(2018) Seungho Choi et al.   NEUROSCIENCE

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

(2018) Moataz Abdalkader et al.   Frontiers in Neuroscience

JNK3 as a Therapeutic Target for Neurodegenerative Diseases

(2018) Xanthi Antoniou et al.   JOURNAL OF ALZHEIMERS DISEASE

Streptocyclinones A and B ameliorate Alzheimer's disease pathological processes in vitro

(2018) Rebeca Alvariño et al.   NEUROPHARMACOLOGY

N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice

(2018) Saravanan S. Karuppagounder et al.   ANNALS OF NEUROLOGY

Pathogenetic role of endothelial nitric oxide synthase uncoupling during lung ischaemia–reperfusion injury†

(2017) Jan F. Gielis et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer’s disease

(2017) Jos Prickaerts et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence?

(2017) Silvia Sorce et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer’s Disease

(2017) Jole Fiorito et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends

(2017) Sergey O. Bachurin et al.   MEDICINAL RESEARCH REVIEWS

NADPH oxidase in brain injury and neurodegenerative disorders

(2017) Merry W. Ma et al.   Molecular Neurodegeneration

QUIMIOINFORMÁTICA: UMA INTRODUÇÃO

(2017) Vinicius Alves et al.   QUIMICA NOVA

Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer’s Therapy?

(2017) Marcelo N. N. Vieira et al.   Frontiers in Aging Neuroscience

Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch

(2017) David Ross et al.   Frontiers in Physiology

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Drug treatments in Alzheimers disease

(2016) R. Briggs et al.   CLINICAL MEDICINE

Drug Development of Small-Molecule Inhibitors of AD-Relevant Kinases as Novel Perspective Multitargeted Approach

(2016) V. Tell et al.   Current Alzheimer Research

Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics

(2016) Michela Rosini et al.   Future Medicinal Chemistry

PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease

(2016) Andrew F. Teich et al.   JOURNAL OF ALZHEIMERS DISEASE

A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation

(2016) Gyun Jee Song et al.   Journal of Neuroinflammation

Recent advances in research on lignans and neolignans

(2016) Rémy Bertrand Teponno et al.   NATURAL PRODUCT REPORTS

Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

(2016) Md. Torequl Islam   NEUROLOGICAL RESEARCH

Nitric Oxide: Exploring the Contextual Link with Alzheimer’s Disease

(2016) Nicholas Asiimwe et al.   Oxidative Medicine and Cellular Longevity

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

(2016) Shanmugam Manoharan et al.   Oxidative Medicine and Cellular Longevity

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease

(2016) Ramon Yarza et al.   Frontiers in Pharmacology

Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Metabolism

On a simple approach for determining applicability domain of QSAR models

(2015) Kunal Roy et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2—a therapeutic target for the treatment of neurodegenerative diseases

(2015) Delinda A. Johnson et al.   FREE RADICAL BIOLOGY AND MEDICINE

PTP1B inhibition suggests a therapeutic strategy for Rett syndrome

(2015) Navasona Krishnan et al.   JOURNAL OF CLINICAL INVESTIGATION

The complexity of the Nrf2 pathway: beyond the antioxidant response

(2015) Ying Huang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline

(2015) Sarah Gourmaud et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition

(2015) Christina Alves Peixoto et al.   MEDIATORS OF INFLAMMATION

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

The Lipoxygenases: Their Regulation and Implication in Alzheimer’s Disease

(2015) Grzegorz A. Czapski et al.   NEUROCHEMICAL RESEARCH

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

Combined structure- and ligand-based virtual screening to evaluate caulerpin analogs with potential inhibitory activity against monoamine oxidase B

(2015) Vitor Prates Lorenzo et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease

(2015) Yash B. Joshi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Diagnostic and prognostic value of serum thioredoxin and DJ-1 in non-small cell lung carcinoma patients

(2015) Jinping Fan et al.   TUMOR BIOLOGY

The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer’s disease phenotype

(2015) Yash B. Joshi et al.   Frontiers in Cellular Neuroscience

Combined structure- and ligand-based virtual screening to evaluate caulerpin analogs with potential inhibitory activity against monoamine oxidase B

(2015) Vitor Prates Lorenzo et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Tanshinone IIA reduces the risk of Alzheimer’s disease by inhibiting iNOS, MMP-2 and NF-κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer’s disease

(2014) PING JIANG et al.   Molecular Medicine Reports

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge

(2014) P G Través et al.   Cell Death & Disease

Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease

(2012) Ana García-Osta et al.   ACS Chemical Neuroscience

5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of alzheimer disease

(2012) Jin Chu et al.   ANNALS OF NEUROLOGY

Mechanisms of Oxidative Glutamate Toxicity: The Glutamate/Cystine Antiporter System xc¯ as a Neuroprotective Drug Target

(2012) Philipp Albrecht et al.   CNS & Neurological Disorders-Drug Targets

The Role of Glucose Transporters in Brain Disease: Diabetes and Alzheimer's Disease

(2012) Kaushik Shah et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

JNK3 as new target in AD?

(2012) Alexandra Flemming   NATURE REVIEWS DRUG DISCOVERY

Tight association of N-terminal and catalytic subunits of rabbit 12/15-lipoxygenase is important for protein stability and catalytic activity

(2011) Igor Ivanov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

NADPH-oxidase activation and cognition in Alzheimer disease progression

(2011) Mubeen A. Ansari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nuclear and mitochondrial DNA oxidation in Alzheimer's disease

(2011) Renato X. Santos et al.   FREE RADICAL RESEARCH

Protection Against Dopaminergic Neurodegeneration in Parkinson’s Disease–Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson’s Disease–Linked PARK7

(2011) Masatoshi Inden et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

Biology of Human Sodium Glucose Transporters

(2011) Ernest M. Wright et al.   PHYSIOLOGICAL REVIEWS

Trust, But Verify: On the Importance of Chemical Structure Curation in Cheminformatics and QSAR Modeling Research

(2010) Denis Fourches et al.   Journal of Chemical Information and Modeling

Rational drug design

(2009) Soma Mandal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer’s disease

(2007) Omidreza Firuzi et al.   FASEB JOURNAL