The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer’s disease phenotype
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Title
The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer’s disease phenotype
Authors
Keywords
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Journal
Frontiers in Cellular Neuroscience
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2015-01-14
DOI
10.3389/fncel.2014.00436
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Note: Only part of the references are listed.- Tau Oligomers and Fibrils Induce Activation of Microglial Cells
- (2018) Inelia Morales et al. JOURNAL OF ALZHEIMERS DISEASE
- Efficacy and Safety of Donepezil, Galantamine, Rivastigmine, and Memantine for the Treatment of Alzheimer's Disease: A Systematic Review and Meta-Analysis
- (2018) Chen-Chen Tan et al. JOURNAL OF ALZHEIMERS DISEASE
- Clinical Pharmacology of Novel Anti-Alzheimer Disease Modifying Medications
- (2014) Filippo Caraci et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits
- (2014) Chelsea E. Corser-Jensen et al. EXPERIMENTAL NEUROLOGY
- Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease
- (2014) Maurice W. Dysken et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- The neglected co-star in the dementia drama: the putative roles of astrocytes in the pathogeneses of major neurocognitive disorders
- (2014) W K Jo et al. MOLECULAR PSYCHIATRY
- Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice
- (2014) Antonio Di Meco et al. NEUROBIOLOGY OF AGING
- Evaluation of the antioxidative properties of lipoxygenase inhibitors
- (2014) Grzegorz A. Czapski et al. Pharmacological Reports
- Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts
- (2014) Yoshihide Kanaoka et al. Allergy Asthma & Immunology Research
- 5-Lipoxygenase Antagonist therapy: a new approach towards targeted cancer chemotherapy
- (2013) K. Bishayee et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy
- (2013) Patrick L. McGeer et al. ACTA NEUROPATHOLOGICA
- The Influence of 5-Lipoxygenase on Alzheimer’s Disease-Related Tau Pathology: In Vivo and In Vitro Evidence
- (2013) Jin Chu et al. BIOLOGICAL PSYCHIATRY
- 5-Lipoxygenase Activating Protein Reduction Ameliorates Cognitive Deficit, Synaptic Dysfunction, and Neuropathology in a Mouse Model of Alzheimer’s Disease
- (2013) Phillip F. Giannopoulos et al. BIOLOGICAL PSYCHIATRY
- Down’s syndrome, neuroinflammation, and Alzheimer neuropathogenesis
- (2013) Donna M Wilcock et al. Journal of Neuroinflammation
- Modulation of 5-Lipoxygenase in Proteotoxicity and Alzheimer's Disease
- (2013) E. Valera et al. JOURNAL OF NEUROSCIENCE
- Markers of oxidant stress that are clinically relevant in aging and age-related disease
- (2013) Kimberly D. Jacob et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease
- (2013) P F Giannopoulos et al. MOLECULAR PSYCHIATRY
- 5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5
- (2013) Jin Chu et al. NEUROBIOLOGY OF AGING
- Modulation of lipopolysaccharide-induced memory insult, γ-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase
- (2013) Yash B. Joshi et al. NEUROBIOLOGY OF AGING
- Leukotriene D4 induces amyloid-β generation via CysLT1R-mediated NF-κB pathways in primary neurons
- (2013) Xiao Yun Wang et al. NEUROCHEMISTRY INTERNATIONAL
- MK886 Reduces Cerebral Amyloid Angiopathy Severity in TgCRND8 Mice
- (2013) Cheryl A. Hawkes et al. Neurodegenerative Diseases
- A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
- (2013) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology
- (2013) Grietje Krabbe et al. PLoS One
- Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease
- (2013) Amanda L. Wright et al. PLoS One
- Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product?
- (2013) Greg T Sutherland et al. REDOX REPORT
- 5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of alzheimer disease
- (2012) Jin Chu et al. ANNALS OF NEUROLOGY
- Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression
- (2012) D. Allan Butterfield et al. ANTIOXIDANTS & REDOX SIGNALING
- Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
- (2012) Paul D. Ray et al. CELLULAR SIGNALLING
- Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways
- (2012) Norbert Zilka et al. Journal of Neuroinflammation
- Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model
- (2012) Jin Chu et al. Journal of Neuroinflammation
- Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice
- (2012) Jin Chu et al. Molecular Neurodegeneration
- A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
- (2012) Thorlakur Jonsson et al. NATURE
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pharmacologic Blockade of 5-Lipoxygenase Improves the Amyloidotic Phenotype of an Alzheimer's Disease Transgenic Mouse Model
- (2011) Jin Chu et al. AMERICAN JOURNAL OF PATHOLOGY
- Assessing the contribution of inflammation in models of Alzheimer's disease: Figure 1
- (2011) Hannah Johnston et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease
- (2011) Patrizia Mecocci et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Nutritional Approaches to Modulate Oxidative Stress in Alzheimers Disease
- (2011) C. B. Pocernich et al. Current Alzheimer Research
- γ-Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease: Disappointments and Hopes
- (2011) Bruno P. Imbimbo et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Glucocorticoids Facilitate Astrocytic Amyloid-β Peptide Deposition by Increasing the Expression of APP and BACE1 and Decreasing the Expression of Amyloid-β-Degrading Proteases
- (2011) Yanyan Wang et al. ENDOCRINOLOGY
- Low-n oligomers as therapeutic targets of Alzheimer’s disease
- (2011) Kenjiro Ono et al. JOURNAL OF NEUROCHEMISTRY
- Alzheimer's Disease: The Challenge of the Second Century
- (2011) D. M. Holtzman et al. Science Translational Medicine
- Overexpression of 5-Lipoxygenase Increases the Neuronal Vulnerability of PC12 Cells to Aβ42
- (2011) Ze-Jian WANG et al. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
- 5-lipoxygenase as an endogenous modulator of amyloid beta formation in vivo
- (2010) Jin Chu et al. ANNALS OF NEUROLOGY
- Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis
- (2010) Olof Rådmark et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Tau in Alzheimer Disease and Related Tauopathies
- (2010) K. Iqbal et al. Current Alzheimer Research
- Lipid Oxidation and Peroxidation in CNS Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities
- (2009) Rao Muralikrishna Adibhatla et al. ANTIOXIDANTS & REDOX SIGNALING
- Increased 5-Lipoxygenase Immunoreactivity in the Hippocampus of Patients With Alzheimer's Disease
- (2008) Milos D. Ikonomovic et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Microglial Dysfunction and Defective -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
- (2008) S. E. Hickman et al. JOURNAL OF NEUROSCIENCE
- 5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer’s disease
- (2007) Omidreza Firuzi et al. FASEB JOURNAL
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