PRRG4 promotes breast cancer metastasis through the recruitment of NEDD4 and downregulation of Robo1

Ndfip Proteins Target Robo Receptors for Degradation and Allow Commissural Axons to Cross the Midline in the Developing Spinal Cord

(2019) Madhavi Gorla et al.   Cell Reports

Breast Cancer Treatment

(2019) Adrienne G. Waks et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Reduced USP33 expression in gastric cancer decreases inhibitory effects of Slit2‐Robo1 signalling on cell migration and EMT

(2019) Yiwen Xia et al.   CELL PROLIFERATION

Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis

(2019) Wei Lu et al.   DEVELOPMENTAL CELL

Gab2 promotes cancer stem cell like properties and metastatic growth of ovarian cancer via downregulation of miR-200c

(2019) Zenghui Fang et al.   EXPERIMENTAL CELL RESEARCH

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017

(2019) et al.   JAMA Oncology

Leptin induces cell migration and invasion in a FAK-Src- dependent manner in breast cancer cells

(2019) Juan Carlos Juárez-Cruz et al.   Endocrine Connections

Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3

(2018) Hao Ke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development

(2018) Rayan Naser et al.   Cancers

The RhoGAP HUM-7/Myo9 integrates signals to modulate RHO-1/RhoA during embryonic morphogenesis in Caenorhabditiselegans

(2018) Andre G. Wallace et al.   DEVELOPMENT

Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor–directed therapies

(2018) Utthara Nayar et al.   NATURE GENETICS

LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis

(2017) Elaine Ngan et al.   Nature Communications

Targeting Androgen Receptor in Treating HER2 Positive Breast Cancer

(2017) Licai He et al.   Scientific Reports

The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene

(2017) Elizabeth D. Justice et al.   PLoS Genetics

Slit-Robo signaling

(2016) Heike Blockus et al.   DEVELOPMENT

Frequent alterations of SLIT2–ROBO1–CDC42 signalling pathway in breast cancer: clinicopathological correlation

(2016) RITTWIKA BHATTACHARYA et al.   JOURNAL OF GENETICS

Novel roles of Src in cancer cell epithelial-to-mesenchymal transition, vascular permeability, microinvasion and metastasis

(2016) Ami Patel et al.   LIFE SCIENCES

Slit/Robo pathway: a promising therapeutic target for cancer

(2015) Rishi K. Gara et al.   DRUG DISCOVERY TODAY

NEDD4: The founding member of a family of ubiquitin-protein ligases

(2015) Natasha Anne Boase et al.   GENE

Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression

(2015) Ruirui Kong et al.   JOURNAL OF CLINICAL INVESTIGATION

Low Expression of Slit2 and Robo1 is Associated with Poor Prognosis and Brain-specific Metastasis of Breast Cancer Patients

(2015) Fengxia Qin et al.   Scientific Reports

The multifaceted roles of Slits and Robos in cortical circuits: from proliferation to axon guidance and neurological diseases

(2014) Heike Blockus et al.   CURRENT OPINION IN NEUROBIOLOGY

Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition

(2014) M. Diepenbruck et al.   JOURNAL OF CELL SCIENCE

Narrowing of the responsible region for severe developmental delay and autistic behaviors in WAGR syndrome down to 1.6 Mb includingPAX6,WT1, andPRRG4

(2013) Toshiyuki Yamamoto et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Cellular Localization and Characterization of Cytosolic Binding Partners for Gla Domain-containing Proteins PRRG4 and PRRG2

(2013) Mustafa N. Yazicioglu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Slit/Robo Signaling Mediates Spatial Positioning of Spiral Ganglion Neurons during Development of Cochlear Innervation

(2013) S.-z. Wang et al.   JOURNAL OF NEUROSCIENCE

Activation of Robo1 Signaling of Breast Cancer Cells by Slit2 from Stromal Fibroblast Restrains Tumorigenesis via Blocking PI3K/Akt/ -Catenin Pathway

(2012) P.-H. Chang et al.   CANCER RESEARCH

TAZ induces growth factor-independent proliferation through activation of EGFR ligand amphiregulin

(2012) Nuo Yang et al.   CELL CYCLE

The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease

(2011) M. Angela Nieto   Annual Review of Cell and Developmental Biology

Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis

(2010) Xiaofeng Zhao et al.   ADVANCED DRUG DELIVERY REVIEWS

A case-controlled validation study of a blood-based seven-gene biomarker panel for colorectal cancer in Malaysia

(2010) Kok-Thye Yip et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The SLIT–ROBO pathway: a regulator of cell function with implications for the reproductive system

(2010) Rachel E Dickinson et al.   REPRODUCTION

Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration

(2009) J. Yuasa-Kawada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SLITs Suppress Tumor Growth In vivo by Silencing Sdf1/Cxcr4 within Breast Epithelium

(2008) R. Marlow et al.   CANCER RESEARCH

Dissecting the ER-Associated Degradation of a Misfolded Polytopic Membrane Protein

(2008) Kunio Nakatsukasa et al.   CELL

Characterization of 11p14-p12 deletion in WAGR syndrome by array CGH for identifying genes contributing to mental retardation and autism

(2008) S. Xu et al.   CYTOGENETIC AND GENOME RESEARCH

Redundant Mechanisms for Regulation of Midline Crossing in Drosophila

(2008) Giorgio F. Gilestro   PLoS One