Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 27, Issue -, Pages 82-88Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2014.03.003
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Funding
- Fondation pour la recherche Medicale (Programme equipe FRM)
- Labex Lifesciences
- Ecole des Neurosciences de Paris Ile-de-France (ENP)
- DIM Cerveau Pensee
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Slit repulsion, mediated by Robe receptors, is known to play a major role in axon guidance in the nervous system. However, recent studies have revealed that in the mammalian cortex these molecules are highly versatile and that their function extends far beyond axon guidance. They act at all phases of development to control neurogenesis, neuronal migration, axon patterning, dendritic outgrowth and spinogenesis. The expression of Robe receptors in cortical and thalamocortical axons (TCAs) is tightly regulated by a combination of transcription factors (TFs), proteases and activity. These findings also suggest that Slit and Robes have influenced the evolution of cortical circuits. Last, novel genetic evidence associates various neurological disorders, such as autism, to abnormal Slit/Robo signaling.
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