HIV-1 infection activates endogenous retroviral promoters regulating antiviral gene expression

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

Transcription profile of human endogenous retroviruses in response to dengue virus serotype 2 infection

(2020) Miao Wang et al.   VIROLOGY

Endogenous Retroviral Envelope Syncytin Induces HIV-1 Spreading and Establishes HIV Reservoirs in Placenta

(2020) Yuyang Tang et al.   Cell Reports

Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells

(2019) Saliha Azébi et al.   EMBO JOURNAL

Origins and evolutionary consequences of ancient endogenous retroviruses

(2019) Welkin E. Johnson   NATURE REVIEWS MICROBIOLOGY

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

(2019) Elisabeth Braun et al.   Cell Reports

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

(2019) Simon Langer et al.   eLife

IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation

(2019) Dominik Hotter et al.   Cell Host & Microbe

Identification and dynamic quantification of regulatory elements using total RNA

(2019) Sascha H. Duttke et al.   GENOME RESEARCH

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

(2019) Bojana Lucic et al.   Nature Communications

Low levels of the immunoregulator Semaphorin 4D (CD100) in sera of HIV patients

(2018) Z. Vadasz et al.   CLINICAL IMMUNOLOGY

Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts

(2018) Tsukasa Oda et al.   JOURNAL OF CELL SCIENCE

CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion

(2018) Rafael Correa-Rocha et al.   PLoS One

Human Endogenous Retroviruses Are Ancient Acquired Elements Still Shaping Innate Immune Responses

(2018) Nicole Grandi et al.   Frontiers in Immunology

The human initiator is a distinct and abundant element that is precisely positioned in focused core promoters

(2017) Long Vo ngoc et al.   GENES & DEVELOPMENT

Transposable elements are the primary source of novelty in primate gene regulation

(2017) Marco Trizzino et al.   GENOME RESEARCH

HIV-1 Infection of Primary CD4 + T Cells Regulates the Expression of Specific Human Endogenous Retrovirus HERV-K (HML-2) Elements

(2017) George R. Young et al.   JOURNAL OF VIROLOGY

DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats

(2017) David Brocks et al.   NATURE GENETICS

HOCOMOCO: towards a complete collection of transcription factor binding models for human and mouse via large-scale ChIP-Seq analysis

(2017) Ivan V Kulakovskiy et al.   NUCLEIC ACIDS RESEARCH

Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers

(2017) Miguel de Mulder et al.   Retrovirology

HBV X Protein induces overexpression of HERV-W env through NF-κB in HepG2 cells

(2017) Cong Liu et al.   VIRUS GENES

FANTOM5 CAGE profiles of human and mouse samples

(2017) Shuhei Noguchi et al.   Scientific Data

Friends-Enemies: Endogenous Retroviruses Are Major Transcriptional Regulators of Human DNA

(2017) Anton A. Buzdin et al.   Frontiers in Chemistry

HERV-K(HML-2), a seemingly silent subtenant - but still waters run deep

(2016) Kirsten Hanke et al.   APMIS

Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity

(2016) Christian Krapp et al.   Cell Host & Microbe

NF-κB and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5′ Long Terminal Repeat

(2016) Mamneet Manghera et al.   JOURNAL OF VIROLOGY

Regulatory evolution of innate immunity through co-option of endogenous retroviruses

(2016) E. B. Chuong et al.   SCIENCE

Phylogenetic Analysis Reveals That ERVs "Die Young" but HERV-H Is Unusually Conserved

(2016) Patrick Gemmell et al.   PLoS Computational Biology

Endogenous retroviral promoter exaptation in human cancer

(2016) Artem Babaian et al.   Mobile DNA

SnapShot: Antiviral Restriction Factors

(2015) Silvia F. Kluge et al.   CELL

Comprehensive identification of genes driven by ERV9-LTRs reveals TNFRSF10B as a re-activatable mediator of testicular cancer cell death

(2015) U Beyer et al.   CELL DEATH AND DIFFERENTIATION

CAGE profiling of ncRNAs in hepatocellular carcinoma reveals widespread activation of retroviral LTR promoters in virus-induced tumors

(2015) Kosuke Hashimoto et al.   GENOME RESEARCH

Viral protein R of HIV type-1 induces retrotransposition and upregulates glutamate synthesis by the signal transducer and activator of transcription 1 signaling pathway

(2015) Akihiro Doi et al.   MICROBIOLOGY AND IMMUNOLOGY

Gene activity in primary T cells infected with HIV89.6: intron retention and induction of genomic repeats

(2015) Scott Sherrill-Mix et al.   Retrovirology

Modulation of human endogenous retrovirus (HERV) transcription during persistent and de novo HIV-1 infection

(2015) Michelle Vincendeau et al.   Retrovirology

Human endogenous retroviruses sustain complex and cooperative regulation of gene-containing loci and unannotated megabase-sized regions

(2015) Martin Sokol et al.   Retrovirology

Widespread contribution of transposable elements to the innovation of gene regulatory networks

(2014) Vasavi Sundaram et al.   GENOME RESEARCH

HIV-1 Infection Leads to Increased Transcription of Human Endogenous Retrovirus HERV-K (HML-2) Proviruses In Vivo but Not to Increased Virion Production

(2014) N. Bhardwaj et al.   JOURNAL OF VIROLOGY

Regulation of the Human Endogenous Retrovirus K (HML-2) Transcriptome by the HIV-1 Tat Protein

(2014) M. J. Gonzalez-Hernandez et al.   JOURNAL OF VIROLOGY

A Primitive Endogenous Lentivirus in a Colugo: Insights into the Early Evolution of Lentiviruses

(2014) Guan-Zhu Han et al.   MOLECULAR BIOLOGY AND EVOLUTION

Histone modifications for human epigenome analysis

(2013) Hiroshi Kimura   JOURNAL OF HUMAN GENETICS

Phenotypic properties of transmitted founder HIV-1

(2013) N. F. Parrish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral protein R of human immunodeficiency virus type-1 induces retrotransposition of long interspersed element-1

(2013) Kenta Iijima et al.   Retrovirology

Endogenous retrovirus-K promoter: a landing strip for inflammatory transcription factors?

(2013) Mamneet Manghera et al.   Retrovirology

Expression of Human Endogenous Retrovirus Type K (HML-2) Is Activated by the Tat Protein of HIV-1

(2012) M. J. Gonzalez-Hernandez et al.   JOURNAL OF VIROLOGY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Expansion of CD8+ T cells lacking Sema4D/CD100 during HIV-1 infection identifies a subset of T cells with decreased functional capacity

(2011) E. M. Eriksson et al.   BLOOD

Human Endogenous Retrovirus K(HML-2) Gag- and Env-Specific T-Cell Responses Are Infrequently Detected in HIV-1-Infected Subjects Using Standard Peptide Matrix-Based Screening

(2011) R. Brad Jones et al.   Clinical and Vaccine Immunology

Characterization of Human Endogenous Retroviral Elements in the Blood of HIV-1-Infected Individuals

(2011) R. Contreras-Galindo et al.   JOURNAL OF VIROLOGY

Analysis of HIV-1 Expression Level and Sense of Transcription by High-Throughput Sequencing of the Infected Cell

(2011) G. Lefebvre et al.   JOURNAL OF VIROLOGY

Identification of Human Endogenous Retrovirus-Specific T Cell Responses in Vertically HIV-1-Infected Subjects

(2011) R. Tandon et al.   JOURNAL OF VIROLOGY

Strong Human Endogenous Retrovirus-Specific T Cell Responses Are Associated with Control of HIV-1 in Chronic Infection

(2011) D. SenGupta et al.   JOURNAL OF VIROLOGY

Generation of Transmitted/Founder HIV-1 Infectious Molecular Clones and Characterization of Their Replication Capacity in CD4 T Lymphocytes and Monocyte-Derived Macrophages

(2011) C. Ochsenbauer et al.   JOURNAL OF VIROLOGY

Mitochondrial HEP27 Is a c-Myb Target Gene That Inhibits Mdm2 and Stabilizes p53

(2010) C. Deisenroth et al.   MOLECULAR AND CELLULAR BIOLOGY

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

NF-κB/Rel: agonist and antagonist roles in HIV-1 latency

(2010) Jonathan KL Chan et al.   Current Opinion in HIV and AIDS

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Interleukin-27 displays interferon-γ-like functions in human hepatoma cells and hepatocytes

(2009) Herdis Bender et al.   HEPATOLOGY

Reconstitution of the Ancestral Glycoprotein of Human Endogenous Retrovirus K and Modulation of Its Functional Activity by Truncation of the Cytoplasmic Domain

(2009) K. Hanke et al.   JOURNAL OF VIROLOGY

Human-Specific Modulation of Transcriptional Activity Provided by Endogenous Retroviral Insertions

(2009) E. Gogvadze et al.   JOURNAL OF VIROLOGY

A rev1–vpu polymorphism unique to HIV-1 subtype A and C strains impairs envelope glycoprotein expression from rev–vpu–env cassettes and reduces virion infectivity in pseudotyping assays

(2009) Matthias H. Kraus et al.   VIROLOGY

Retroviral promoters in the human genome

(2008) Andrew B. Conley et al.   BIOINFORMATICS

A transitional endogenous lentivirus from the genome of a basal primate and implications for lentivirus evolution

(2008) R. J. Gifford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EBV LMP-2A employs a novel mechanism to transactivate the HERV-K18 superantigen through its ITAM

(2008) Francis C. Hsiao et al.   VIROLOGY