Article
Plant Sciences
Mijin Kim, Bongjun Sur, Thea Villa, Seung Yeol Nah, Seikwan Oh
Summary: The study showed that Gintonin has anti-arthritic effects by inhibiting the expression of inflammatory mediators and preventing the nuclear translocation of NF-kappa B/p65. Additionally, it suppressed arthritis symptoms in a mice model of collagen-induced arthritis.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Abdullah M. Alnuqaydan, Abdulmajeed Almutary, Gh Rasool Bhat, Tanveer Ahmad Mir, Shadil Ibrahim Wani, Mohd Younis Rather, Shabir Ahmad Mir, Bader Alshehri, Sulaiman Alnasser, Faten M. Ali Zainy, Bilal Rah
Summary: This study evaluates the anti-inflammatory and immunomodulatory effects of Withaferin A (WA) in immune cells extracted from BALB/c mice. The results show that WA exhibits anti-inflammatory and immunomodulatory activity by modulating inflammatory signaling pathways and reducing the expression of proinflammatory cytokines.
Article
Food Science & Technology
Yunhui Min, Yunji Heo, Fang Feng, Dahye Kim, Mangeun Kim, Jiwon Yang, Hyo Jin Kim, Youngheun Jee, Mrinmoy Ghosh, Inhae Kang, Young-Ok Son
Summary: Excessive consumption of sucrose leads to hepatic fibrosis and inflammation, increasing the risk of rheumatoid arthritis (RA) pathogenesis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Bilal Aslam, Asif Hussain, Muhammad Naeem Faisal, Zia-ud-Din Sindhu, Rifat Ullah Khan, Ibrahim A. Alhidary, Shabana Naz, Vincenzo Tufarelli
Summary: This study evaluated the anti-arthritic activity of curcumin and meloxicam co-loaded PLGA nanoparticles in adjuvant-induced arthritic rats. The results showed that the co-loaded nanoparticles significantly reduced paw swelling and arthritic score, restored body weight and immune organ index, and attenuated serum inflammatory markers and oxidative stress parameters in the arthritic rats. Furthermore, the nanoparticles modulated cytokine expressions and exhibited a greater anti-arthritic effect compared to the individual compounds.
Article
Immunology
Mahmood Ahmad Khan, Gulam Rabbani, Monika Kumari, Mohd Jahir Khan
Summary: The objective of this study was to investigate the anti-inflammatory and anti-arthritic effects of ellagic acid (EA) in collagen-induced arthritis (CIA). The findings demonstrated that EA significantly reduced inflammation and oxidative stress, and inhibited the development of arthritis in rats. These results suggest that EA could serve as a potential new drug for the treatment of arthritis.
INFLAMMOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Samiyah K. Al-Shammari, Doha M. Al-Nouri, Shaista Arzoo, Laila Naif Al-Harbi
Summary: This study evaluated the protective effect of different dietary omega-6/omega-3 ratios in oils obtained from various nuts against morphological features and markers of inflammation on an adjuvant-induced arthritis rat model. The results showed that the serum levels of inflammatory markers were significantly reduced in all treatment groups.
APPLIED SCIENCES-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Malgorzata Krol, Patrycja Kupnicka, Mateusz Bosiacki, Dariusz Chlubek
Summary: Stretching is a popular element in physiotherapy and rehabilitation, which can help reduce the disabling effects of chronic health conditions. Recent studies have shown that stretching not only has systemic anti-inflammatory effects, but also local effects. This review summarizes the current knowledge on the anti-inflammatory properties of stretching and suggests that a better understanding of this may increase its importance in the treatment and recovery of diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Hamsalakshmi, Suresh Joghee, Sreeram P. Kalarikkal, Gopinath M. Sundaram, T. Durai Ananda Kumar, Saravana Babu Chidambaram
Summary: The study demonstrated the anti-inflammatory effects of extracts from the aerial parts of Trichodesma indicum, with fraction FE showing the strongest ability to reduce inflammatory cytokines without cytotoxicity. The major compound in FE, 1,2-benzenedicarboxylic acid diisooctyl ester, exhibited good inhibition against key inflammatory targets.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Immunology
Hao Yuan, Si-Xian Wu, Yi-Feng Zhou, Fang Peng
Summary: The study demonstrates that SPD can protect CIA mice by inhibiting the polarization of M1 macrophages, reducing pro-inflammatory cytokines, and promoting the release of anti-inflammatory factors.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Rheumatology
Grant S. Schulert, Alex Pickering, Thuy Do, Sanjeev Dhakal, Ndate Fall, Daniel Schnell, Mario Medvedovic, Nathan Salomonis, Sherry Thornton, Alexei A. Grom
Summary: Macrophages with an 'IFN-gamma response' phenotype and TRIM8 overexpression were expanded in the bone marrow from an MAS patient. TRIM8 is also upregulated in SJIA monocytes, and augments macrophage IFN-gamma response in vitro, providing both a candidate molecular mechanism and potential therapeutic target for monocyte hyper-responsiveness to IFN gamma in cytokine storms including MAS.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Liliana F. Mellor, Nuria Gago-Lopez, Latifa Bakiri, Felix N. Schmidt, Bjorn Busse, Simon Rauber, Maria Jimenez, Diego Megias, Sergio Oterino-Soto, Ricardo Sanchez-Prieto, Sergei Grivennikov, Xinzhu Pu, Julia Oxford, Andreas Ramming, Georg Schett, Erwin F. Wagner
Summary: Keratinocyte-derived S100A9 plays a regulatory role in psoriatic skin and joint disease. In addition, S100A9 and CP have the potential to serve as biomarkers for identifying Ps patients at risk of developing PsA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Nassima Bekaddour, Nikaia Smith, Benoit Beitz, Alba Llibre, Tom Dott, Anne Baudry, Anne-Sophie Korganow, Sebastien Nisole, Richard Mouy, Sylvain Breton, Brigitte Bader-Meunier, Darragh Duffy, Benjamin Terrier, Benoit Schneider, Pierre Quartier, Mathieu P. Rodero, Jean-Philippe Herbeuval
Summary: This study investigated the effects of targeting the CXCR4 receptor as an alternative strategy for treating rheumatoid arthritis (RA). The results showed that CXCR4 targeting with CB effectively inhibited the production of key inflammatory cytokines by monocytes and led to a reduction in disease progression in a mouse model of collagen-induce arthritis. These findings suggest that targeting CXCR4 with CB could be a promising therapeutic option for chronic and viral-induced inflammatory diseases, including RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sara Sattar, Arham Shabbir, Muhammad Shahzad, Tasleem Akhtar, Syed Muneeb Anjum, Mohammed Bourhia, Hiba-Allah Nafidi, Yousef A. Bin Jardan, Musaab Dauelbait, Aisha Mobashar
Summary: The study found that Lawsone possesses anti-arthritic properties and can ameliorate arthritis symptoms through immunomodulatory and anti-inflammatory effects. The results demonstrate that Lawsone inhibits the progression of arthritis and reduces paw edema.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
G. Halpert, I. Katz, O. Shovman, S. Tarasov, K. K. Ganina, N. Petrova, M. Tocut, A. Volkov, I. Barshack, M. Blank, H. Amital
Summary: Treatment with IVIG significantly reduced clinical arthritis score in DBA/1j mice with collagen-induced arthritis. IVIG showed a mode of action by decreasing circulating levels of inflammatory cytokines and inhibiting anti-collagen antibodies. Histopathological examination revealed that IVIG treatment prevented inflammatory immune cells from migrating into cartilage and synovium, reducing joint damage and preserving joint architecture. These results suggest the valuable anti-inflammatory treatment of IVIG in experimental RA.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Neurosciences
Marlina O. Cordoba-Moreno, Mariana Trivilin Mendes, Regina P. Markus, Pedro Augusto Fernandes
Summary: Chronic inflammatory diseases are influenced by causal stimuli and the activation of the immune-pineal axis (IPA) may play a role in determining disease susceptibility. The murine model of collagen-induced arthritis provides insights into the different responses of resistant and susceptible animals. Imbalances in the levels of melatonin and corticosterone, as well as cytokine production, may contribute to the development of rheumatoid arthritis.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Agriculture, Multidisciplinary
Oana Emilia Constantin, Nicoleta Stanciuc, Yinzhuo Yan, Ioana Otilia Ghinea, Claudia Ungureanu, Adrian Circiumaru, Deliang Wang, Natasa Poklar Ulrih, Gabriela Rapeanu
Summary: Anthocyanins extracted from grape skins were microencapsulated in vesicles with different polymers, and the stability and behavior of the vesicles were characterized. The vesicles showed stability in simulated gastrointestinal fluids and were successful in obtaining new light enriched mayonnaises.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Food Science & Technology
Zala Gombac, Ilja Gasan Osojnik Crnivec, Mihaela Skrt, Katja Istenic, Andreja Knez Knafelj, Igor Pravst, Natasa Poklar Ulrih
Summary: The study focused on preparing stable encapsulates of lutein and lutein esters using feasible techniques. Fine suspensions and lecithin emulsions showed high encapsulation efficiencies and superior stability over the course of 250 days of storage under specific conditions.
Editorial Material
Cell Biology
Gordana Kocic, Andrej Veljkovic, Dusan Sokolovic, Natasa Poklar Ulrih
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biology
Iztok Prislan, Tomaz Urbic, Natasa Poklar Ulrih
Summary: G-quadruplexes are DNA sequences rich in guanines that can form four-stranded structures. Due to their potential role in important biological processes, they have attracted the interest of researchers. This study investigates the complex polymorphism of d(G(4)T(4)G(3)) quadruplexes at different K+ concentrations and shows that the population size of different conformations can be manipulated by cooling rate and/or K+ concentration. A kinetic model is used to describe the observed conformational transitions.
Article
Biochemistry & Molecular Biology
Dino Jordanoski, Damjana Drobne, Neza Repar, Iztok Dogsa, Polona Mrak, Romana Cerc-Korosec, Andrijana Sever Skapin, Peter Nadrah, Natasa Poklar Ulrih
Summary: By using heulandite-calcium as a carrier material, the structure and stability of hemoglobin can be improved, and its loading capacity can be increased. Introducing a PEGylated lipid bilayer can decrease the premature release of hemoglobin and increase colloidal stability, while showing no cytotoxicity to cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Polona Megusar, David Stopar, Natasa Poklar Ulrih, Iztok Dogsa, Iztok Prislan
Summary: Understanding the effects of hydroxypropyl methyl cellulose and xanthan gum on gluten-free dough can contribute to the development of better quality gluten-free bread with optimized ingredients.
Article
Engineering, Chemical
Ana Todorovic, Luka Sturm, Ana Salevic-Jelic, Steva Levic, Ilja Gasan Osojnik Crnivec, Iztok Prislan, Mihaela Skrt, Ana Bjekovic, Natasa Poklar Ulrih, Viktor Nedovic
Summary: This study aimed to encapsulate anthocyanin-rich bilberry extract using freeze-drying and investigate the effects of different wall materials and extract contents on the properties of the encapsulates. The use of maltodextrin provided the best protection to the anthocyanins. The obtained encapsulates have potential for the development of food products with added nutritional benefits.
Article
Food Science & Technology
Mihaela Skrt, Alen Albreht, Irena Vovk, Oana Emilia Constantin, Gabriela Rapeanu, Mija Sezun, Ilja Gasan Osojnik Crnivec, Uros Zalar, Natasa Poklar Ulrih
Summary: This study comprehensively examined the phenolic composition and antioxidative activity of a new pomegranate cultivar grown in the Northwest Istria region. The results showed that pomegranate peel extracts had the highest total phenolic content, while water peel extracts exhibited the highest antioxidative activity. Additionally, the degradation of anthocyanins in pomegranate juice increased after storage. Pomegranate peel was also found to be a sustainable inedible food source for papermaking.
Article
Agriculture, Multidisciplinary
Rodrigo Gonzalez-Ortega, Carla Daniela Di Mattia, Paola Pittia, Poklar Ulrih Natasa
Summary: The study investigated the impact of isothermal treatment and pH on the degradation kinetics of phenolic compounds in olive leaf extract solutions and their radical scavenging activity. It was found that oleuropein, the major compound, degraded more rapidly at lower pH and higher temperatures. Hydroxytyrosol concentration increased at the same pH due to oleuropein hydrolysis. Verbascoside degradation only occurred at pH 6.0. Despite changes in individual compounds, the overall reducing capacity of the compounds remained relatively constant after thermal treatments. These findings provide insights for predicting and optimizing thermal treatments in foods enriched with olive leaf extracts.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Luka Sturm, Ilja Gasan Osojnik Crnivec, Iztok Prislan, Natasa Poklar Ulrih
Summary: Propolis, a resinous compound made by bees, has well-known biological activity. This study compared the antibacterial activity, lipid phase transition effect, and inhibition of UV-induced lipid oxidation between encapsulated and non-encapsulated propolis. The results showed that non-encapsulated propolis had quicker effects, particularly in antibacterial activity. Furthermore, the synergistic effects of propolis compounds on lipid membranes were studied, revealing complex interactions and the need for mathematical modeling.
Article
Biochemistry & Molecular Biology
Nikola Stamenkovic, Janez Cerkovnik, Natasa Poklar Ulrih
Summary: Antioxidants, which connect biology and chemistry, are now being studied theoretically with the advancement of theoretical and computational methods. This paper presents a novel method that aims to reduce the wall times for DFT calculations in the study of antioxidants. By applying the inversion of theory level to the universal chemical scavenger model, the accuracy and wall time obtained suggest that this methodology can be generally applied to antioxidant thermodynamics for some costly DFT methods.
Review
Chemistry, Multidisciplinary
Jan Kejzar, Ilja Gasan Osojnik Crnivec, Natasa Poklar Ulrih
Summary: Archaeosomes, made from archaeal lipids, possess remarkable thermostability, resistance to enzymatic degradation, long-term stability, and immunomodulatory properties. This review focuses on the physicochemical properties and stability of total polar lipids from Aeropyrum pernix K1, specifically glycerol ether lipids with isoprenoid groups attached to glycerol via ether linkages. The effects of temperature and pH on the stability, structure, fluidity, and permeability of pure C-25,C-25 archaeosomes were examined using various techniques. The potential use of archaeal lipids as a targeted drug delivery system is also discussed.
Article
Food Science & Technology
Spela Gruden, Jernej Oberckal, Bojana Bogovic, Natasa Poklar Ulrih
Summary: Lactoperoxidase, a glycoprotein with potential as a natural biopreservative, exhibits antimicrobial activity. Its structural stability and enzymatic activity rely on factors such as pH, buffer concentration, and ions. Depletion of iron and calcium ions can lower thermal stability and enzymatic activity.
INTERNATIONAL DAIRY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Poornima Budime Santhosh, Tihomir Tenev, Luka Sturm, Natasa Poklar Ulrih, Julia Genova
Summary: Gold nanoparticles were used to assess their effects on the structure and fluidity of lipid membranes. The study found that the nanoparticles did not significantly alter the membrane structure and fluidity, suggesting their suitability for biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Harindra D. Sathkumara, Janet L. Eaton, Matt A. Field, Brenda L. Govan, Natkunam Ketheesan, Andreas Kupz
Summary: Tuberculosis is one of the deadliest infectious diseases globally, and type 2 diabetes significantly increases the risk of developing active TB. Recent evidence shows that the microbiota plays a significant role in host response to infection, injury, and neoplastic changes. Animal models are crucial for assessing new treatments and understanding immunological defects in comorbid patients with increased TB susceptibility.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2021)