ASK1 contributes to fibrosis and dysfunction in models of kidney disease

ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension

(2018) Grant R. Budas et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial

(2017) Rohit Loomba et al.   HEPATOLOGY

Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

(2017) Ying-Ying Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease

(2017) Steven G. Coca et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nephron number, hypertension, and CKD: physiological and genetic insight from humans and animal models

(2017) Xuexiang Wang et al.   PHYSIOLOGICAL GENOMICS

Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure

(2017) Marion Lanier et al.   ACS Medicinal Chemistry Letters

Chronic kidney disease

(2017) Paola Romagnani et al.   Nature Reviews Disease Primers

Diabetes and Kidney Disease: Role of Oxidative Stress

(2016) Jay C. Jha et al.   ANTIOXIDANTS & REDOX SIGNALING

Podocytes: the Weakest Link in Diabetic Kidney Disease?

(2016) Jamie S. Lin et al.   Current Diabetes Reports

The next generation of therapeutics for chronic kidney disease

(2016) Matthew D. Breyer et al.   NATURE REVIEWS DRUG DISCOVERY

Antioxidants in Translational Medicine

(2015) Harald H.H.W. Schmidt et al.   ANTIOXIDANTS & REDOX SIGNALING

ASK1 Inhibitor Halts Progression of Diabetic Nephropathy inNos3-Deficient Mice

(2015) Greg H. Tesch et al.   DIABETES

Uremic Toxins, Oxidative Stress, and Renal Fibrosis: An Interwined Complex

(2015) Chia-Ter Chao et al.   JOURNAL OF RENAL NUTRITION

Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker

(2015) Wenjun Ju et al.   Science Translational Medicine

Thymoquinone inhibits TNF-α-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation

(2015) Sadiq Umar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Podocytes, Signaling Pathways, and Vascular Factors in Diabetic Kidney Disease

(2014) Frank C. Brosius et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Pleiotropic functions of TIMP-1 in patients with chronic kidney disease

(2014) Kinga Musiał et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular mechanisms of diabetic kidney disease

(2014) Kimberly Reidy et al.   JOURNAL OF CLINICAL INVESTIGATION

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

(2014) Pietro Ciceri et al.   Nature Chemical Biology

The role of ligand efficiency metrics in drug discovery

(2014) Andrew L. Hopkins et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic approaches to diabetic nephropathy—beyond the RAS

(2014) Beatriz Fernandez-Fernandez et al.   Nature Reviews Nephrology

Thioredoxin-mimetic peptides (TXM) reverse auranofin induced apoptosis and restore insulin secretion in insulinoma cells

(2013) Moshe Cohen-Kutner et al.   BIOCHEMICAL PHARMACOLOGY

Antioxidants as therapies: can we improve on nature?

(2013) Michael P. Murphy   FREE RADICAL BIOLOGY AND MEDICINE

Crystal structures of ASK1-inhibtor complexes provide a platform for structure-based drug design

(2013) Onkar Singh et al.   PROTEIN SCIENCE

Apoptosis Signal–Regulating Kinase 1 Deficiency Attenuates Vascular Injury–Induced Neointimal Hyperplasia by Suppressing Apoptosis in Smooth Muscle Cells

(2012) Takashi Tasaki et al.   AMERICAN JOURNAL OF PATHOLOGY

Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors

(2012) Yoshito Terao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of Cross-Species Shared Transcriptional Networks of Diabetic Nephropathy in Human and Mouse Glomeruli

(2012) Jeffrey B. Hodgin et al.   DIABETES

Oxidative stress, anti-oxidant therapies and chronic kidney disease

(2012) DAVID M SMALL et al.   NEPHROLOGY

Alleviation of oxidative stress by potent and selective thioredoxin-mimetic peptides

(2011) Niv Bachnoff et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification of 3H-Naphtho[1,2,3-de]quinoline-2,7-diones as Inhibitors of Apoptosis Signal-Regulating Kinase 1 (ASK1)

(2011) Galyna P. Volynets et al.   JOURNAL OF MEDICINAL CHEMISTRY

Irbesartan delays progression of nephropathy as measured by estimated glomerular filtration rate: post hoc analysis of the Irbesartan Diabetic Nephropathy Trial

(2011) Marc Evans et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mechanism of Oxidative Stress-Induced ASK1-Catalyzed MKK6 Phosphorylation

(2010) Emmanuel Sturchler et al.   BIOCHEMISTRY

Identification of novel ASK1 inhibitors using virtual screening

(2010) Masako Okamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway

(2010) Xiaoli Guo et al.   EMBO Molecular Medicine

Apoptosis signal-regulating kinase 1 deficiency eliminates cardiovascular injuries induced by high-salt diet

(2010) Keiichiro Kataoka et al.   JOURNAL OF HYPERTENSION

Mechanisms of Tubulointerstitial Fibrosis

(2010) M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pathologic Classification of Diabetic Nephropathy

(2010) T. W. C. Tervaert et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Oxidative stress in early diabetic nephropathy: fueling the fire

(2010) Dhruv K. Singh et al.   Nature Reviews Endocrinology

Chemical target and pathway toxicity mechanisms defined in primary human cell systems

(2009) Ellen L. Berg et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Role of MKK3–p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice

(2008) A. K. H. Lim et al.   DIABETOLOGIA

Diabetic eNOS knockout mice develop distinct macro- and microvascular complications

(2008) Sumathy Mohan et al.   LABORATORY INVESTIGATION

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Delayed inhibition of p38 mitogen-activated protein kinase ameliorates renal fibrosis in obstructive nephropathy

(2008) M. Nishida et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Apoptosis Signal-Regulating Kinase 1 in Stress and Immune Response

(2007) Kohsuke Takeda et al.   Annual Review of Pharmacology and Toxicology