PCNA activates the MutLγ endonuclease to promote meiotic crossing over

Human MutLγ, the MLH1–MLH3 heterodimer, is an endonuclease that promotes DNA expansion

(2020) Lyudmila Y. Kadyrova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I

(2019) Melissa Toledo et al.   PLoS Genetics

Mechanistic View and Genetic Control of DNA Recombination during Meiosis

(2018) Marie-Claude Marsolier-Kergoat et al.   MOLECULAR CELL

MutSγ-Induced DNA Conformational Changes Provide Insights into Its Role in Meiotic Recombination

(2018) Sudipta Lahiri et al.   BIOPHYSICAL JOURNAL

The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans

(2017) Carol M. Manhart et al.   PLOS BIOLOGY

Distinct DNA-binding surfaces in the ATPase and linker domains of MutLγ determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair

(2017) Corentin Claeys Bouuaert et al.   PLoS Genetics

Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation

(2016) Stephen Gray et al.   Annual Review of Genetics

A personal historical view of DNA mismatch repair with an emphasis on eukaryotic DNA mismatch repair

(2016) Richard D. Kolodner   DNA REPAIR

Endonuclease activities of MutLα and its homologs in DNA mismatch repair

(2016) Lyudmila Y. Kadyrova et al.   DNA REPAIR

Roles for mismatch repair family proteins in promoting meiotic crossing over

(2016) Carol M. Manhart et al.   DNA REPAIR

Pervasive and Essential Roles of the Top3-Rmi1 Decatenase Orchestrate Recombination and Facilitate Chromosome Segregation in Meiosis

(2015) Shangming Tang et al.   MOLECULAR CELL

The sliding clamp tethers the endonuclease domain of MutL to DNA

(2015) Monica C. Pillon et al.   NUCLEIC ACIDS RESEARCH

Meiotic Recombination: The Essence of Heredity

(2015) Neil Hunter   Cold Spring Harbor Perspectives in Biology

Mlh1-Mlh3, a Meiotic Crossover and DNA Mismatch Repair Factor, Is a Msh2-Msh3-stimulated Endonuclease

(2014) Maria V. Rogacheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TheSaccharomyces cerevisiaeMlh1-Mlh3 Heterodimer Is an Endonuclease That Preferentially Binds to Holliday Junctions

(2014) Lepakshi Ranjha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Topoisomerase II mediates meiotic crossover interference

(2014) Liangran Zhang et al.   NATURE

The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage

(2014) Sucheta Mukherjee et al.   NUCLEIC ACIDS RESEARCH

Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes

(2013) S. Schaetzlein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An expanded tool kit for the auxin-inducible degron system in budding yeast

(2013) Magdalena Morawska et al.   YEAST

Genetic Analysis of mlh3 Mutations Reveals Interactions Between Crossover Promoting Factors During Meiosis in Baker’s Yeast

(2013) Megan Sonntag Brown et al.   G3-Genes Genomes Genetics

Delineation of Joint Molecule Resolution Pathways in Meiosis Identifies a Crossover-Specific Resolvase

(2012) Kseniya Zakharyevich et al.   CELL

Structure of the Endonuclease Domain of MutL: Unlicensed to Cut

(2010) Monica C. Pillon et al.   MOLECULAR CELL

Temporally and Biochemically Distinct Activities of Exo1 during Meiosis: Double-Strand Break Resection and Resolution of Double Holliday Junctions

(2010) Kseniya Zakharyevich et al.   MOLECULAR CELL

PCNA function in the activation and strand direction of MutL  endonuclease in mismatch repair

(2010) A. Pluciennik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

(2009) Kohei Nishimura et al.   NATURE METHODS

Meiosis I Is Established through Division-Specific Translational Control of a Cyclin

(2008) Thomas M. Carlile et al.   CELL

A Mutation in the Putative MLH3 Endonuclease Domain Confers a Defect in Both Mismatch Repair and Meiosis in Saccharomyces cerevisiae

(2008) K. T. Nishant et al.   GENETICS