标题
Structural basis for sequestration and autoinhibition of cGAS by chromatin
作者
关键词
-
出版物
NATURE
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-09-11
DOI
10.1038/s41586-020-2748-0
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Molecular mechanisms and cellular functions of cGAS–STING signalling
- (2020) Karl-Peter Hopfner et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus
- (2019) Matteo Gentili et al. Cell Reports
- cGAS in action: Expanding roles in immunity and inflammation
- (2019) Andrea Ablasser et al. SCIENCE
- The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
- (2019) Christian Zierhut et al. CELL
- DNA sensing by the cGAS–STING pathway in health and disease
- (2019) Mona Motwani et al. NATURE REVIEWS GENETICS
- Chromatin‐bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death
- (2019) Hui Jiang et al. EMBO JOURNAL
- cGAS and CD-NTase enzymes: structure, mechanism, and evolution
- (2019) Philip J Kranzusch CURRENT OPINION IN STRUCTURAL BIOLOGY
- Tight nuclear tethering of cGAS is essential for preventing autoreactivity
- (2019) Hannah E Volkman et al. eLife
- DNA-induced liquid phase condensation of cGAS activates innate immune signaling
- (2018) Mingjian Du et al. SCIENCE
- Structural basis of mitochondrial receptor binding and constriction by DRP1
- (2018) Raghav Kalia et al. NATURE
- Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
- (2018) Haipeng Liu et al. NATURE
- The allosteric activation of cGAS underpins its dynamic signaling landscape
- (2018) Richard M Hooy et al. eLife
- cGAS surveillance of micronuclei links genome instability to innate immunity
- (2017) Karen J. Mackenzie et al. NATURE
- Mitotic progression following DNA damage enables pattern recognition within micronuclei
- (2017) Shane M. Harding et al. NATURE
- Cytoplasmic chromatin triggers inflammation in senescence and cancer
- (2017) Zhixun Dou et al. NATURE
- cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders
- (2017) Liudmila Andreeva et al. NATURE
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- Addressing preferred specimen orientation in single-particle cryo-EM through tilting
- (2017) Yong Zi Tan et al. NATURE METHODS
- UCSF ChimeraX: Meeting modern challenges in visualization and analysis
- (2017) Thomas D. Goddard et al. PROTEIN SCIENCE
- Recognition of the nucleosome by chromatin factors and enzymes
- (2016) Robert K McGinty et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- CTFFIND4: Fast and accurate defocus estimation from electron micrographs
- (2015) Alexis Rohou et al. JOURNAL OF STRUCTURAL BIOLOGY
- Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA
- (2015) Anna-Maria Herzner et al. NATURE IMMUNOLOGY
- OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines
- (2014) Jonathan L. Schmid-Burgk et al. GENOME RESEARCH
- Rapid Purification of Recombinant Histones
- (2014) Henrike Klinker et al. PLoS One
- The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
- (2014) Xu Zhang et al. Cell Reports
- Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
- (2013) Pu Gao et al. CELL
- Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
- (2013) Xin Li et al. IMMUNITY
- Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
- (2013) Xu Zhang et al. MOLECULAR CELL
- cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
- (2013) Andrea Ablasser et al. NATURE
- Structural mechanism of cytosolic DNA sensing by cGAS
- (2013) Filiz Civril et al. NATURE
- RELION: Implementation of a Bayesian approach to cryo-EM structure determination
- (2012) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
- (2012) L. Sun et al. SCIENCE
- A Tale of Tails: How Histone Tails Mediate Chromatin Compaction in Different Salt and Linker Histone Environments†
- (2009) Gaurav Arya et al. JOURNAL OF PHYSICAL CHEMISTRY A
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