Synthetic group A streptogramin antibiotics that overcome Vat resistance

OPLS3e: Extending Force Field Coverage for Drug-Like Small Molecules

(2019) Katarina Roos et al.   Journal of Chemical Theory and Computation

A concise route to virginiamycin M2

(2019) Qi Li et al.   TETRAHEDRON

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Cryo-EM in drug discovery: achievements, limitations and prospects

(2018) Jean-Paul Renaud et al.   NATURE REVIEWS DRUG DISCOVERY

cisTEM, user-friendly software for single-particle image processing

(2018) Timothy Grant et al.   eLife

Antibiotic Resistance ABC-F Proteins: Bringing Target Protection into the Limelight

(2018) Liam K. R. Sharkey et al.   ACS Infectious Diseases

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

High resolution single particle cryo-electron microscopy using beam-image shift

(2018) Anchi Cheng et al.   JOURNAL OF STRUCTURAL BIOLOGY

Improving Accuracy, Diversity, and Speed with Prime Macrocycle Conformational Sampling

(2017) Dan Sindhikara et al.   Journal of Chemical Information and Modeling

Modular, Scalable Synthesis of Group A Streptogramin Antibiotics

(2017) Qi Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Predictive compound accumulation rules yield a broad-spectrum antibiotic

(2017) Michelle F. Richter et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state

(2017) Ilya A. Osterman et al.   NUCLEIC ACIDS RESEARCH

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

(2017) Wilson Wong et al.   Nature Microbiology

Pristinamycin in the treatment of MSSA bone and joint infection

(2016) Florent Valour et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A platform for the discovery of new macrolide antibiotics

(2016) Ian B. Seiple et al.   NATURE

ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection

(2016) Liam K. R. Sharkey et al.   mBio

High-resolution structure of the Escherichia coli ribosome

(2015) Jonas Noeske et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

High-resolution structure of the Escherichia coli ribosome

(2015) Jonas Noeske et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery

(2014) Peter M. Wright et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synergy of Streptogramin Antibiotics Occurs Independently of Their Effects on Translation

(2014) Jonas Noeske et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Potential for Reduction of Streptogramin A Resistance Revealed by Structural Analysis of Acetyltransferase VatA

(2014) Peter J. Stogios et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome

(2014) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Jaguar: A high-performance quantum chemistry software program with strengths in life and materials sciences

(2013) Art D. Bochevarov et al.   INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY

Regio-selectively reduced streptogramin A analogue, 5,6-dihydrovirginiamycin M1exhibits improved potency against MRSA

(2013) N.H. Hoang et al.   LETTERS IN APPLIED MICROBIOLOGY

Broad-substrate screen as a tool to identify substrates for bacterial Gcn5-relatedN-acetyltransferases with unknown substrate specificity

(2012) Misty L. Kuhn et al.   PROTEIN SCIENCE

In vitro pharmacokinetic/pharmacodynamic activity of NXL103 versus clindamycin and linezolid against clinical Staphylococcus aureus and Streptococcus pyogenes isolates

(2011) Celine Vidaillac et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Total Synthesis of (−)-Virginiamycin M2: Application of Crotylsilanes Accessed by Enantioselective Rh(II) or Cu(I) Promoted Carbenoid Si–H Insertion

(2011) Jie Wu et al.   JOURNAL OF ORGANIC CHEMISTRY

The VSGB 2.0 model: A next generation energy model for high resolution protein structure modeling

(2011) Jianing Li et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Total Synthesis of (−)-Virginiamycin M2

(2010) Jie Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Binding and Action of CEM-101, a New Fluoroketolide Antibiotic That Inhibits Protein Synthesis

(2010) B. Llano-Sotelo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

electronic Ligand Builder and Optimization Workbench(eLBOW): a tool for ligand coordinate and restraint generation

(2009) Nigel W. Moriarty et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The A–Z of bacterial translation inhibitors

(2009) Daniel N. Wilson   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

xia2: an expert system for macromolecular crystallography data reduction

(2009) G. Winter   JOURNAL OF APPLIED CRYSTALLOGRAPHY