Computational design of transmembrane pores

Packing of apolar side chains enables accurate design of highly stable membrane proteins

(2019) Marco Mravic et al.   SCIENCE

Programmable Artificial Cells Using Histamine-Responsive Synthetic Riboswitch

(2019) Mohammed Dwidar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Accurate computational design of multipass transmembrane proteins

(2018) Peilong Lu et al.   SCIENCE

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1

(2018) Xiaojing Pan et al.   SCIENCE

Structures reveal opening of the store-operated calcium channel Orai

(2018) Xiaowei Hou et al.   eLife

Maintaining and breaking symmetry in homomeric coiled-coil assemblies

(2018) Guto G. Rhys et al.   Nature Communications

An ace in the hole for DNA sequencing

(2017) Michael Eisenstein   NATURE

Membrane pores: from structure and assembly, to medicine and technology

(2017) Robert J. C. Gilbert et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Design of self-assembling transmembrane helical bundles to elucidate principles required for membrane protein folding and ion transport

(2017) Nathan H. Joh et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Membrane-spanning α-helical barrels as tractable protein-design targets

(2017) Ai Niitsu et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The coming of age of de novo protein design

(2016) Po-Ssu Huang et al.   NATURE

A monodisperse transmembrane α-helical peptide barrel

(2016) Kozhinjampara R. Mahendran et al.   Nature Chemistry

De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity

(2016) S. E. Boyken et al.   SCIENCE

Genetically targeted single-channel optical recording reveals multiple Orai1 gating states and oscillations in calcium influx

(2015) Joseph L. Dynes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liposome display for in vitro selection and evolution of membrane proteins

(2014) Satoshi Fujii et al.   Nature Protocols

De novo design of a transmembrane Zn2+-transporting four-helix bundle

(2014) Nathan H. Joh et al.   SCIENCE

Computational design of water-soluble α-helical barrels

(2014) Andrew R. Thomson et al.   SCIENCE

High thermodynamic stability of parametrically designed helical bundles

(2014) Po-Ssu Huang et al.   SCIENCE

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

(2013) Lin Tang et al.   NATURE

In vitro evolution of  -hemolysin using a liposome display

(2013) S. Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salt dependence of the radius of gyration and flexibility of single-stranded DNA in solution probed by small-angle x-ray scattering

(2012) Adelene Y. L. Sim et al.   PHYSICAL REVIEW E

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Probing Designability via a Generalized Model of Helical Bundle Geometry

(2010) Gevorg Grigoryan et al.   JOURNAL OF MOLECULAR BIOLOGY

Continuous base identification for single-molecule nanopore DNA sequencing

(2009) James Clarke et al.   Nature Nanotechnology

Simultaneous prediction of protein folding and docking at high resolution

(2009) Rhiju Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA