GDNF / RET Signaling Pathway Activation Eliminates Lewy Body Pathology in Midbrain Dopamine Neurons

Initiation and propagation of α-synuclein aggregation in the nervous system

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The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

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Extended Treatment with Glial Cell Line-Derived Neurotrophic Factor in Parkinson’s Disease

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Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson’s disease

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CDNF Protein Therapy in Parkinson’s Disease

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Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

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Internalization, axonal transport and release of fibrillar forms of alpha-synuclein

(2018) Gregor Bieri et al.   NEUROBIOLOGY OF DISEASE

Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti–α-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease

(2018) Joseph Jankovic et al.   JAMA Neurology

Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease

(2018) Anna-Maija Penttinen et al.   Frontiers in Neurology

Trophic factors for Parkinson's disease: Where are we and where do we go from here?

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Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models

(2018) Andreas Weihofen et al.   NEUROBIOLOGY OF DISEASE

Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies

(2017) Richard J. Karpowicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dampened Amphetamine-Stimulated Behavior and Altered Dopamine Transporter Function in the Absence of Brain GDNF

(2017) Jaakko J. Kopra et al.   JOURNAL OF NEUROSCIENCE

Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models

(2017) Xiaomin Su et al.   MOLECULAR THERAPY

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration

(2017) Hisham Abdelmotilib et al.   NEUROBIOLOGY OF DISEASE

Dicer and microRNAs protect adult dopamine neurons

(2017) Piotr Chmielarz et al.   Cell Death & Disease

Glial Cell Line-Derived Neurotrophic Factor Gene Delivery in Parkinson's Disease: A Delicate Balance between Neuroprotection, Trophic Effects, and Unwanted Compensatory Mechanisms

(2017) Liliane Tenenbaum et al.   Frontiers in Neuroanatomy

A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat

(2017) Yulia A. Sidorova   Frontiers in Pharmacology

The GDNF-GFRα1 complex promotes the development of hippocampal dendritic arbors and spines via NCAM

(2016) Dolores Irala et al.   DEVELOPMENT

Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration

(2016) Saurav Brahmachari et al.   JOURNAL OF CLINICAL INVESTIGATION

A regulatable AAV vector mediating GDNF biological effects at clinically-approved sub-antimicrobial doxycycline doses

(2016) Abdelwahed Chtarto et al.   Molecular Therapy-Methods & Clinical Development

Direct Observation of α-Synuclein Amyloid Aggregates in Endocytic Vesicles of Neuroblastoma Cells

(2016) Mihaela M. Apetri et al.   PLoS One

GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model

(2015) Piotr Hadaczek et al.   EXPERIMENTAL NEUROLOGY

GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease

(2015) Edgar R. Kramer et al.   FEBS LETTERS

Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene Therapy

(2015) Andrii Domanskyi et al.   HUMAN GENE THERAPY

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

(2015) Katrina L. Paumier et al.   NEUROBIOLOGY OF DISEASE

Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer

(2014) Ekta Agarwal et al.   BMC CANCER

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

(2014) Anne-Laure Mahul-Mellier et al.   HUMAN MOLECULAR GENETICS

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K-independent AKT activation in cancers: A treasure trove for novel therapeutics

(2012) Kiran Mahajan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

 -Synuclein-Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons

(2012) M. Decressac et al.   Science Translational Medicine

GDNF fails to exert neuroprotection in a rat  -synuclein model of Parkinson's disease

(2011) M. Decressac et al.   BRAIN

Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin

(2011) Maxim M. Bespalov et al.   JOURNAL OF CELL BIOLOGY

Is GDNF beneficial in Parkinson disease?

(2011) Barry J. Hoffer et al.   Nature Reviews Neurology

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Medium-throughput computer aided micro-island method to assay embryonic dopaminergic neuron cultures in vitro

(2010) A. Planken et al.   JOURNAL OF NEUROSCIENCE METHODS

Constitutive Ret signaling is protective for dopaminergic cell bodies but not for axonal terminals

(2009) Jelena Mijatovic et al.   NEUROBIOLOGY OF AGING

Good statistical practice in pharmacology Problem 2

(2007) M Lew   BRITISH JOURNAL OF PHARMACOLOGY