Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer

Cell survival and metastasis regulation by Akt signaling in colorectal cancer

(2013) Ekta Agarwal et al.   CELLULAR SIGNALLING

A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle

(2012) Yu-Chiang Lai et al.   BIOCHEMICAL JOURNAL

Preclinical evaluation of the AKT inhibitor MK-2206 in nasopharyngeal carcinoma cell lines

(2012) Brigette B. Y. Ma et al.   INVESTIGATIONAL NEW DRUGS

Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia

(2012) C Simioni et al.   LEUKEMIA

Rho Kinase Phosphorylation Promotes Ezrin-Mediated Metastasis in Hepatocellular Carcinoma

(2011) Y. Chen et al.   CANCER RESEARCH

Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells

(2011) Nicole Grabinski et al.   CELLULAR SIGNALLING

Histone Deacetylase Inhibitor Belinostat Represses Survivin Expression through Reactivation of Transforming Growth Factor β (TGFβ) Receptor II Leading to Cancer Cell Death

(2011) Sanjib Chowdhury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Akt Inhibitor MK2206 Synergizes, but Perifosine Antagonizes, the BRAFV600EInhibitor PLX4032 and the MEK1/2 Inhibitor AZD6244 in the Inhibition of Thyroid Cancer Cells

(2011) Ruixin Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MK-2206, a Novel Allosteric Inhibitor of Akt, Synergizes with Gefitinib against Malignant Glioma via Modulating Both Autophagy and Apoptosis

(2011) Y. Cheng et al.   MOLECULAR CANCER THERAPEUTICS

Testing of the Akt/PKB inhibitor MK-2206 by the pediatric preclinical testing program

(2011) Richard Gorlick et al.   PEDIATRIC BLOOD & CANCER

Identification of a Novel TGFβ/PKA Signaling Transduceome in Mediating Control of Cell Survival and Metastasis in Colon Cancer

(2011) Sanjib Chowdhury et al.   PLoS One

IAP Regulation of Metastasis

(2010) Swarna Mehrotra et al.   CANCER CELL

HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways

(2010) Hiromichi Nakabayashi et al.   CANCER SCIENCE

The Effects of Epidermal Growth Factor Receptor Activation and Attenuation of the TGFβ Pathway in an Orthotopic Model of Colon Cancer

(2009) Melanie Ongchin et al.   JOURNAL OF SURGICAL RESEARCH

Current overview of the role of Akt in cancer studies via applied immunohistochemistry

(2008) Viktor Shtilbans et al.   Annals of Diagnostic Pathology

Regulation of apoptosis-inducing factor-mediated, cisplatin-induced apoptosis by Akt

(2008) X Yang et al.   BRITISH JOURNAL OF CANCER

Ezrin silencing by small hairpin RNA reverses metastatic behaviors of human breast cancer cells

(2008) Qiong Li et al.   CANCER LETTERS

Heterogeneity of Receptor Function in Colon Carcinoma Cells Determined by Cross-talk between Type I Insulin-like Growth Factor Receptor and Epidermal Growth Factor Receptor

(2008) Y. P. Hu et al.   CANCER RESEARCH

Transforming Growth Factor   Induces Apoptosis through Repressing the Phosphoinositide 3-Kinase/AKT/Survivin Pathway in Colon Cancer Cells

(2008) J. Wang et al.   CANCER RESEARCH