Therapeutic Perspectives of Adenosine Deaminase Inhibition in Cardiovascular Diseases

Total adenosine deaminase highly correlated with adenosine deaminase 2 activity in serum

(2020) Zhao-Wei Gao et al.   ANNALS OF THE RHEUMATIC DISEASES

Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers

(2020) Carina Herman-de-Sousa et al.   Cells

Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

(2020) Lukas F. Mager et al.   SCIENCE

Inhibition of LPS-stimulated ecto-adenosine deaminase attenuates endothelial cell activation

(2019) Barbara Kutryb-Zajac et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Adenosine deaminase-1 delineates human follicular helper T cell function and is altered with HIV

(2019) Virginie Tardif et al.   Nature Communications

Nucleotide ecto-enzyme metabolic pattern and spatial distribution in calcific aortic valve disease; its relation to pathological changes and clinical presentation

(2019) Barbara Kutryb-Zajac et al.   Clinical Research in Cardiology

Adenosine receptors in modulation of central nervous system disorders

(2019) Hira Choudhury et al.   CURRENT PHARMACEUTICAL DESIGN

Adenosine deaminase inhibition

(2019) S. Bagheri et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Unstable Carotid Plaque is Associated With Coagulation Function and Platelet Activity Evaluated by Thrombelastography

(2019) Jiaqi Li et al.   Journal of Stroke & Cerebrovascular Diseases

Evaluation of Plasma Adenosine as a Marker of Cardiovascular Risk: Analytical and Biological Considerations

(2019) Trevor Simard et al.   Journal of the American Heart Association

Adenosine, Via A 2B Receptors, Inhibits Human (P-SMC) Progenitor Smooth Muscle Cell Growth

(2019) Raghvendra K. Dubey et al.   HYPERTENSION

Curcumin inhibits the expression of ornithine decarboxylase and adenosine deaminase genes in MCF-7 human breast cancer cells

(2018) Hossein Abbaspour et al.   Archives of Biological Sciences

Adenosine signaling and the immune system: When a lot could be too much

(2018) Luca Antonioli et al.   IMMUNOLOGY LETTERS

The Inside Story of Adenosine

(2018) Marcella Camici et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

S -adenosylhomocysteine Hydrolase Participates in DNA Methylation Inheritance

(2018) V.K. Chaithanya Ponnaluri et al.   JOURNAL OF MOLECULAR BIOLOGY

Adenosine deaminase deficiency: a review

(2018) Aisling M. Flinn et al.   Orphanet Journal of Rare Diseases

Macrophage polarization and acceleration of atherosclerotic plaques in a swine model

(2018) Seul-Gee Lee et al.   PLoS One

Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction

(2018) Yonggang Ma et al.   Translational Research

Molecular Evidence of Adenosine Deaminase Linking Adenosine A2A Receptor and CD26 Proteins

(2018) Estefanía Moreno et al.   Frontiers in Pharmacology

Who Is Who in Adenosine Transport

(2018) Marçal Pastor-Anglada et al.   Frontiers in Pharmacology

The Role of Adenosine Receptors in Psychostimulant Addiction

(2018) Inmaculada Ballesteros-Yáñez et al.   Frontiers in Pharmacology

The ecto-enzymes CD73 and adenosine deaminase modulate 5′-AMP-derived adenosine in myofibroblasts of the rat small intestine

(2018) Anna Bin et al.   Purinergic Signalling

Adenosine deaminase activity in type 2 diabetes mellitus: does it have any role?

(2018) A. Niraula et al.   BMC Endocrine Disorders

Adenosine deaminase inhibition suppresses progression of 4T1 murine breast cancer by adenosine receptor-dependent mechanisms

(2018) Barbara Kutryb-Zajac et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Vascular extracellular adenosine metabolism in mice correlates with susceptibility to atherosclerosis

(2018) Barbara Kutryb-Zajac et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

The effects of pro- and anti-atherosclerotic factors on intracellular nucleotide concentration in murine endothelial cells

(2018) Barbara Kutryb-Zajac et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Adenosine Deaminase (ADA)-Deficient Severe Combined Immune Deficiency (SCID): Molecular Pathogenesis and Clinical Manifestations

(2017) Kathryn L. Bradford et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels

(2017) Andrea Leiva et al.   MOLECULAR ASPECTS OF MEDICINE

Effector and Regulatory T Cells Roll at High Shear Stress by Inducible Tether and Sling Formation

(2017) Michael Abadier et al.   Cell Reports

Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

(2017) Chang Xia et al.   Journal of Diabetes Research

Purinergic Signalling: Therapeutic Developments

(2017) Geoffrey Burnstock   Frontiers in Pharmacology

Targeting Adenosine Receptors for the Treatment of Cardiac Fibrosis

(2017) Elizabeth A. Vecchio et al.   Frontiers in Pharmacology

Focused screening to identify new adenosine kinase inhibitors

(2016) Meryem Köse et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Increased activity of vascular adenosine deaminase in atherosclerosis and therapeutic potential of its inhibition

(2016) Barbara Kutryb-Zajac et al.   CARDIOVASCULAR RESEARCH

Platelet aggregation and serum adenosine deaminase (ADA) activity in pregnancy associated with diabetes, hypertension and HIV

(2016) Claudio A. M. Leal et al.   CELL BIOCHEMISTRY AND FUNCTION

Human adenosine deaminases ADA1 and ADA2 bind to different subsets of immune cells

(2016) Yuliia Kaljas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias

(2016) Ajith A. Welihinda et al.   CELLULAR SIGNALLING

Inhibitory activity of hibifolin on adenosine deaminase- experimental and molecular modeling study

(2016) K.G. Arun et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Identification of adenosine deaminase inhibitors from Tofu wastewater and litchi peel and their synergistic anticancer and antibacterial activities with cordycepin

(2016) He Ni et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Activation of the adenosine A2A receptor attenuates experimental autoimmune encephalomyelitis and is associated with increased intracellular calcium levels

(2016) Yumei Liu et al.   NEUROSCIENCE

M1- and M2-Type Macrophage Responses Are Predictive of Adverse Outcomes in Human Atherosclerosis

(2016) Monica de Gaetano et al.   Frontiers in Immunology

Adenosine 2B Receptor Activation Reduces Myocardial Reperfusion Injury by Promoting Anti-Inflammatory Macrophages Differentiation via PI3K/Akt Pathway

(2015) Yikui Tian et al.   Oxidative Medicine and Cellular Longevity

Ticagrelor potentiates adenosine-induced stimulation of neutrophil chemotaxis and phagocytosis

(2015) Khalaf F. Alsharif et al.   VASCULAR PHARMACOLOGY

Recent Advances in Dipeptidyl-Peptidase-4 Inhibition Therapy: Lessons from the Bench and Clinical Trials

(2015) Jixin Zhong et al.   Journal of Diabetes Research

Moonlighting Adenosine Deaminase: A Target Protein for Drug Development

(2014) Antoni Cortés et al.   MEDICINAL RESEARCH REVIEWS

Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2

(2014) Qing Zhou et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of Platelet Activation and Thrombus Formation by Adenosine and Inosine: Studies on Their Relative Contribution and Molecular Modeling

(2014) Eduardo Fuentes et al.   PLoS One

Combined 2D and 3D-QSAR, molecular modelling and docking studies of pyrazolodiazepinones as novel phosphodiesterase 2 inhibitors

(2014) S.G. Bhansali et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Adenosine, adenosine receptors and their role in glucose homeostasis and lipid metabolism

(2013) Milka Koupenova et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hot shot induction and reperfusion with a specific blocker of the es-ENT1 nucleoside transporter before and after hypothermic cardioplegia abolishes myocardial stunning in acutely ischemic hearts despite metabolic derangement: Hot shot drug delivery before hypothermic cardioplegia

(2013) Anwar Saad Abd-Elfattah et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Cardiovascular adenosine receptors: Expression, actions and interactions

(2013) John P. Headrick et al.   PHARMACOLOGY & THERAPEUTICS

Anti-inflammatory effects of inosine in allergic lung inflammation in mice: evidence for the participation of adenosine A2A and A3 receptors

(2013) Fernanda da Rocha Lapa et al.   Purinergic Signalling

Extracellular guanosine regulates extracellular adenosine levels

(2012) Edwin K. Jackson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of Neutrophil Function by Adenosine

(2012) Kathryn E. Barletta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors

(2012) Eduard Gracia et al.   FASEB JOURNAL

Purinergic system ecto-enzymes participate in the thromboregulation of patients with indeterminate form of Chagas disease

(2012) Viviane do Carmo Gonçalves Souza et al.   Purinergic Signalling

Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis

(2011) Liqun Ma et al.   CARDIOVASCULAR RESEARCH

Changes in Adenosine Deaminase Activity in Patients with Type 2 Diabetes Mellitus and Effect of DPP-4 Inhibitor Treatment on ADA Activity

(2011) Jae-Geun Lee et al.   Diabetes & Metabolism Journal

Extracellular Adenosine: A Safety Signal That Dampens Hypoxia-Induced Inflammation During Ischemia

(2010) Almut Grenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: A crucial role for Krüppel-like factor 2

(2010) L.J.H. van Tits et al.   ATHEROSCLEROSIS

Structural Basis for the Growth Factor Activity of Human Adenosine Deaminase ADA2

(2010) Anton V. Zavialov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages

(2010) A. V. Zavialov et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Role of Zn2+on the Structure and Stability of Murine Adenosine Deaminase†

(2010) Weiling Niu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Preclinical Assessment of the Treatment of Second-Stage African Trypanosomiasis with Cordycepin and Deoxycoformycin

(2009) Suman K. Vodnala et al.   PLoS Neglected Tropical Diseases

Effect of Cardiovascular Drugs on Adenosine Deaminase Activity

(2008) Edward Kowalczyk et al.   ANGIOLOGY