Moonlighting Adenosine Deaminase: A Target Protein for Drug Development

Plasma adenosine deaminase isoform 2 in cancer patients undergoing chemotherapy

(2016) E.L. Roberts et al.   BRITISH JOURNAL OF BIOMEDICAL SCIENCE

A2Aadenosine receptors and Parkinson's disease severity

(2013) I. Casetta et al.   ACTA NEUROLOGICA SCANDINAVICA

Potential roles of adenosine deaminase-2 in diabetic retinopathy

(2013) Nehal M. Elsherbiny et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ligand-Specific Binding and Activation of the Human Adenosine A2B Receptor

(2013) Dominik Thimm et al.   BIOCHEMISTRY

Allosteric modulators of human A2B adenosine receptor

(2013) Maria Letizia Trincavelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Adenosine signaling in airways: Toward a promising antiasthmatic approach

(2013) Carla Cicala et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Suitability of the adenosine antagonist istradefylline for the treatment of Parkinson's disease: pharmacokinetic and clinical considerations

(2013) Thomas Müller   Expert Opinion on Drug Metabolism & Toxicology

Gene therapy of primary T cell immunodeficiencies

(2013) Alain Fischer et al.   GENE

Ecto-5'-Nucleotidase (CD73)-Mediated Formation of Adenosine Is Critical for the Striatal Adenosine A2A Receptor Functions

(2013) E. Augusto et al.   JOURNAL OF NEUROSCIENCE

Evaluation of acetylcholinesterase and adenosine deaminase activities in brain and erythrocytes and proinflammatory cytokine levels in rats submitted to neonatal hypoxia-ischemia model

(2013) Victor Camera Pimentel et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Adenosine receptors as drug targets — what are the challenges?

(2013) Jiang-Fan Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Homodimerization of adenosine A1 receptors in brain cortex explains the biphasic effects of caffeine

(2013) Eduard Gracia et al.   NEUROPHARMACOLOGY

Chronic treatment with DCPCX, an adenosine A1 antagonist, worsens long-term memory

(2013) Craig Vollert et al.   NEUROSCIENCE LETTERS

Cardiovascular adenosine receptors: Expression, actions and interactions

(2013) John P. Headrick et al.   PHARMACOLOGY & THERAPEUTICS

Unveiling the binding mode of adenosine deaminase inhibitors to the active site of the enzyme: implication for rational drug design

(2013) Maria Letizia Trincavelli   Purinergic Signalling

A2B adenosine receptor blockade inhibits growth of prostate cancer cells

(2013) Qiang Wei et al.   Purinergic Signalling

E-ADA activity in erythrocytes of lambs experimentally infected with Haemonchus contortus and its possible functional correlations with anemia

(2013) Aleksandro S. Da Silva et al.   RESEARCH IN VETERINARY SCIENCE

CD39 and CD73 in immunity and inflammation

(2013) Luca Antonioli et al.   TRENDS IN MOLECULAR MEDICINE

Attenuating myocardial ischemia by targeting A2B adenosine receptors

(2013) Holger K. Eltzschig et al.   TRENDS IN MOLECULAR MEDICINE

High cell surface CD26-associated activities and low plasma adenosine concentration in fibromyalgia

(2012) Régis Guieu et al.   ANNALS OF THE RHEUMATIC DISEASES

An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: Potential implications in cardiovascular disease

(2012) Jixin Zhong et al.   ATHEROSCLEROSIS

Moonlighting is mainstream: Paradigm adjustment required

(2012) Shelley D. Copley   BIOESSAYS

Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities in prostate cancer patients: Influence of Gleason score, treatment and bone metastasis

(2012) Vanessa Battisti et al.   BIOMEDICINE & PHARMACOTHERAPY

Gene therapy for ADA-SCID: defining the factors for successful outcome

(2012) H. B. Gaspar   BLOOD

Outcome of hematopoietic stem cell transplantation for adenosine deaminase-deficient severe combined immunodeficiency

(2012) A. Hassan et al.   BLOOD

Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans

(2012) F. Candotti et al.   BLOOD

Erythrocyte adenosine deaminase: diagnostic value for Diamond-Blackfan anaemia

(2012) John H. Fargo et al.   BRITISH JOURNAL OF HAEMATOLOGY

Activities of enzymes that hydrolyze adenine nucleotides in lymphocytes from patients with rheumatoid arthritis

(2012) Jeandre Augusto dos Santos Jaques et al.   CELL BIOCHEMISTRY AND FUNCTION

Potential Therapeutic Relevance of Adenosine A2B and A2A Receptors in the Central Nervous System

(2012) Patrizia Popoli et al.   CNS & Neurological Disorders-Drug Targets

Adenosine Deaminase in the Modulation of Immune System and its Potential as a Novel Target for Treatment of Inflammatory Disorders

(2012) Luca Antonioli et al.   CURRENT DRUG TARGETS

Gene Therapy for Severe Combined Immunodeficiency due to Adenosine Deaminase Deficiency

(2012) Claudia A. Montiel-Equihua et al.   CURRENT GENE THERAPY

Oligomerization of G Protein-Coupled Receptors: Computational Methods

(2012) J. Selent et al.   CURRENT MEDICINAL CHEMISTRY

Adenosine A2A Antagonists in Parkinson’s Disease: What’s Next?

(2012) Patrick Hickey et al.   Current Neurology and Neuroscience Reports

Gene therapy for primary immunodeficiencies: part 1

(2012) Marina Cavazzana-Calvo et al.   CURRENT OPINION IN IMMUNOLOGY

The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease

(2012) Harry Karmouty-Quintana et al.   FASEB JOURNAL

The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors

(2012) Eduard Gracia et al.   FASEB JOURNAL

Oligomer Size of the Serotonin 5-Hydroxytryptamine 2C (5-HT2C) Receptor Revealed by Fluorescence Correlation Spectroscopy with Photon Counting Histogram Analysis

(2012) Katharine Herrick-Davis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy

(2012) Aisha V. Sauer et al.   JOURNAL OF CLINICAL INVESTIGATION

A2A Adenosine Receptor Signaling in Lymphocytes and the Central Nervous System Regulates Inflammation during Experimental Autoimmune Encephalomyelitis

(2012) J. H. Mills et al.   JOURNAL OF IMMUNOLOGY

Synthesis and Characterization of Novel 2-Amino-3-benzoylthiophene Derivatives as Biased Allosteric Agonists and Modulators of the Adenosine A1 Receptor

(2012) Celine Valant et al.   JOURNAL OF MEDICINAL CHEMISTRY

The adenosine deaminases of Plasmodium vivax and Plasmodium falciparum exhibit surprising differences in ligand specificity

(2012) Andrei Ivanov et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons

(2012) J. M. Hawryluk et al.   JOURNAL OF NEUROPHYSIOLOGY

Myocardial protection in beating heart cardiac surgery: I: Pre- or postconditioning with inhibition of es-ENT1 nucleoside transporter and adenosine deaminase attenuates post-MI reperfusion-mediated ventricular fibrillation and regional contractile dysfunction

(2012) Anwar Saad Abd-Elfattah et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Ectoenzymes and cholinesterase activity and biomarkers of oxidative stress in patients with lung cancer

(2012) Daniela Zanini et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

Comparison of Superoxide Dismutase, Glutathione Peroxidase and Adenosine Deaminase Activities between Respiratory and Nocturnal Subtypes of Patients with Panic Disorder

(2012) Osman Ozdemir et al.   NEUROPSYCHOBIOLOGY

Opiate-induced changes in brain adenosine levels and narcotic drug responses

(2012) M. Wu et al.   NEUROSCIENCE

Diagnostic Accuracy of Adenosine Deaminase and Lymphocyte Proportion in Pleural Fluid for Tuberculous Pleurisy in Different Prevalence Scenarios

(2012) Alberto Garcia-Zamalloa et al.   PLoS One

The A2b Adenosine Receptor Modulates Glucose Homeostasis and Obesity

(2012) Hillary Johnston-Cox et al.   PLoS One

Adenosine Deaminase Enhances the Immunogenicity of Human Dendritic Cells from Healthy and HIV-Infected Individuals

(2012) Víctor Casanova et al.   PLoS One

Sampling protein motion and solvent effect during ligand binding

(2012) V. Limongelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic system ecto-enzymes participate in the thromboregulation of patients with indeterminate form of Chagas disease

(2012) Viviane do Carmo Gonçalves Souza et al.   Purinergic Signalling

Adenosine as an endogenous immunoregulator in cancer pathogenesis: where to go?

(2012) V. Kumar   Purinergic Signalling

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4+T effector cells in patients with head and neck squamous cell carcinoma

(2012) Magis Mandapathil et al.   OncoImmunology

Receptor Oligomerization in Family B1 of G-Protein-Coupled Receptors: Focus on BRET Investigations and the Link between GPCR Oligomerization and Binding Cooperativity

(2012) Sarah Norklit Roed et al.   Frontiers in Endocrinology

Adenosine A2A Receptor Antagonists and Parkinson’s Disease

(2011) Brian C. Shook et al.   ACS Chemical Neuroscience

Pharmacological Characterization of Adenosine Receptors on Isolated Human Bronchi

(2011) Luigino Calzetta et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Studies on the adenosine deaminase-catalyzed conversion of adenosine and nucleoside prodrugs by different capillary electrophoresis modes

(2011) Lu Pei et al.   ANALYTICAL BIOCHEMISTRY

A2Aadenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase

(2011) Eduard Gracia et al.   BIOCHEMICAL JOURNAL

The four cysteine residues in the second extracellular loop of the human adenosine A2B receptor: Role in ligand binding and receptor function

(2011) Anke C. Schiedel et al.   BIOCHEMICAL PHARMACOLOGY

Organization of Higher-Order Oligomers of the Serotonin1A Receptor Explored Utilizing Homo-FRET in Live Cells

(2011) Sourav Ganguly et al.   BIOPHYSICAL JOURNAL

Myeloid dysplasia and bone marrow hypocellularity in adenosine deaminase-deficient severe combined immune deficiency

(2011) R. Sokolic et al.   BLOOD

Surface markers of lymphocyte activation and markers of cell proliferation

(2011) Maria Shipkova et al.   CLINICA CHIMICA ACTA

Analysis of serum adenosine deaminase (ADA) and ADA1 and ADA2 isoenzyme activities in HIV positive and HIV–HBV co-infected patients

(2011) Iraj Khodadadi et al.   CLINICAL BIOCHEMISTRY

Adenosine A1 Receptors in the Central Nervous System: Their Functions in Health and Disease, and Possible Elucidation by PET Imaging

(2011) S. Paul et al.   CURRENT MEDICINAL CHEMISTRY

New Insight Into A1 Adenosine Receptors in Diabetes Treatment

(2011) Marzena Wojcik et al.   CURRENT PHARMACEUTICAL DESIGN

Adenosine and Related Drugs in Brain Diseases: Present and Future in Clinical Trials

(2011) Luisa V. Lopes et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Role of Extracellular Adenosine in Chemical Neurotransmission in the Hippocampus and Basal Ganglia: Pharmacological and Clinical Aspects

(2011) Beata Sperlagh et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Role of Adenosine in the Regulation of Sleep

(2011) Zhi-Li Huang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Molecular mechanism and structural basis of interactions of dipeptidyl peptidase IV with adenosine deaminase and human immunodeficiency virus type-1 transcription transactivator

(2011) Hua Fan et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Adenosine deaminase activity in patients with Crohnʼs disease

(2011) Irit Maor et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Adenosine A2A-Receptor Antagonism and Pathophysiology of Parkinson’s Disease and Drug-Induced Movement Disorders

(2011) Jaime Kulisevsky et al.   EUROPEAN NEUROLOGY

Adenosine dysfunction in epilepsy

(2011) Detlev Boison   GLIA

An old enzyme for current needs: adenosine deaminase and a dendritic cell vaccine for HIV

(2011) Jose M Martinez-Navio et al.   IMMUNOLOGY AND CELL BIOLOGY

Moonlighting proteins in neurological disorders

(2011) Judit Ovádi   IUBMB LIFE

High Levels of Adenosine Deaminase on Dendritic Cells Promote Autoreactive T Cell Activation and Diabetes in Nonobese Diabetic Mice

(2011) F. Ghaemi Oskouie et al.   JOURNAL OF IMMUNOLOGY

Adenosine Deaminase-like Protein 1 (ADAL1): Characterization and Substrate Specificity in the Hydrolysis of N6- or O6-Substituted Purine or 2-Aminopurine Nucleoside Monophosphates

(2011) Eisuke Murakami et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery

(2011) Bruce J. Melancon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Astrocyte-Derived Adenosine and A1 Receptor Activity Contribute to Sleep Loss-Induced Deficits in Hippocampal Synaptic Plasticity and Memory in Mice

(2011) C. Florian et al.   JOURNAL OF NEUROSCIENCE

The Role of the A2a Receptor Agonist, Regadenoson, in Modulating Hepatic Artery Flow in the Porcine Small-for-Size Liver Graft

(2011) Xiaocheng Zhu et al.   JOURNAL OF SURGICAL RESEARCH

Hairy cell leukemia: a successful model for experimental therapeutics—pentostatin and new ideas

(2011) Michael R. Grever   LEUKEMIA & LYMPHOMA

Mechanism of Action of Pentostatin and Cladribine in Hairy Cell Leukemia

(2011) James B. Johnston   LEUKEMIA & LYMPHOMA

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

(2011) Guillaume Lebon et al.   NATURE

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Past, present and future of A2A adenosine receptor antagonists in the therapy of Parkinson's disease

(2011) Marie Therese Armentero et al.   PHARMACOLOGY & THERAPEUTICS

Adenosine deaminase from Streptomyces coelicolor: Recombinant expression, purification and characterization

(2011) Somchai Pornbanlualap et al.   PROTEIN EXPRESSION AND PURIFICATION

Serum adenosine deaminase may predict disease activity in rheumatoid arthritis

(2011) Batool Zamani et al.   RHEUMATOLOGY INTERNATIONAL

Serum adenosine deaminase activity in patients with systemic lupus erythematosus: a study based on ADA1 and ADA2 isoenzymes pattern

(2011) Reza Saghiri et al.   RHEUMATOLOGY INTERNATIONAL

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

Hematopoietic Stem Cell Gene Therapy for Adenosine Deaminase-Deficient Severe Combined Immunodeficiency Leads to Long-Term Immunological Recovery and Metabolic Correction

(2011) H. B. Gaspar et al.   Science Translational Medicine

Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine

(2011) Andrew S. Doré et al.   STRUCTURE

Exploring a role for heteromerization in GPCR signalling specificity

(2010) Raphael Rozenfeld et al.   BIOCHEMICAL JOURNAL

Allosteric modulation of adenosine receptors

(2010) Anikó Göblyös et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Adenosine receptors and cancer

(2010) Stefania Gessi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Recent developments in adenosine receptor ligands and their potential as novel drugs

(2010) Christa E. Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Dimerization and ligand binding affect the structure network of A2A adenosine receptor

(2010) Francesca Fanelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Moonlighting proteins: An intriguing mode of multitasking

(2010) Daphne H.E.W. Huberts et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats

(2010) T Takahashi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Enzymes that hydrolyze adenine nucleotides in patients with ischemic heart disease

(2010) Margarete D. Bagatini et al.   CLINICA CHIMICA ACTA

Activities of enzymes that hydrolyze adenine nucleotides in platelets from patients with rheumatoid arthritis

(2010) Lara V. Becker et al.   CLINICAL BIOCHEMISTRY

Adenosine deaminase in saliva as a diagnostic marker of squamous cell carcinoma of tongue

(2010) Balwant Rai et al.   Clinical Oral Investigations

Update on gene therapy for adenosine deaminase-deficient severe combined immunodeficiency

(2010) Francesca Ferrua et al.   Current Opinion in Allergy and Clinical Immunology

Use of pleural fluid levels of adenosine deaminase and interferon gamma in the diagnosis of tuberculous pleuritis

(2010) Rafał Krenke et al.   CURRENT OPINION IN PULMONARY MEDICINE

A2A Receptor Ligands: Past, Present and Future Trends

(2010) C. Manera et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A1 Receptors Ligands: Past, Present and Future Trends

(2010) S. Schenone et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Bone Marrow Transplantation and Alternatives for Adenosine Deaminase Deficiency

(2010) H. Bobby Gaspar   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Structural Basis for the Growth Factor Activity of Human Adenosine Deaminase ADA2

(2010) Anton V. Zavialov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Different Extent of B and T Cell Immune Reconstitution after Hematopoietic Stem Cell Transplantation and Enzyme Replacement Therapies in SCID Patients with Adenosine Deaminase Deficiency

(2010) F. Serana et al.   JOURNAL OF IMMUNOLOGY

A2B Adenosine Receptors Protect against Sepsis-Induced Mortality by Dampening Excessive Inflammation

(2010) B. Csoka et al.   JOURNAL OF IMMUNOLOGY

Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells

(2010) José M. Martinez-Navio et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages

(2010) A. V. Zavialov et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Structure-Based Discovery of Novel Chemotypes for Adenosine A2AReceptor Antagonists

(2010) Vsevolod Katritch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Discovery of A2AAdenosine Receptor Ligands

(2010) Jens Carlsson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigations into the Origin of the Molecular Recognition of Several Adenosine Deaminase Inhibitors

(2010) Irina Gillerman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantification of Indirect Pathway Inhibition by the Adenosine A2a Antagonist SYN115 in Parkinson Disease

(2010) K. J. Black et al.   JOURNAL OF NEUROSCIENCE

Adenosine A2Areceptors and their role in drug addiction

(2010) Robyn M. Brown et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

The Role of Zn2+on the Structure and Stability of Murine Adenosine Deaminase†

(2010) Weiling Niu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Adenosine A1 receptor antagonists in clinical research and development

(2010) Berthold Hocher   KIDNEY INTERNATIONAL

Large granular lymphocyte leukemia: natural history and response to treatment

(2010) Anne F. Fortune et al.   LEUKEMIA & LYMPHOMA

Delineating the Mode of Action of Adenosine A1 Receptor Allosteric Modulators

(2010) C. Valant et al.   MOLECULAR PHARMACOLOGY

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

(2010) Laura Albizu et al.   Nature Chemical Biology

20 years of gene therapy for SCID

(2010) Alain Fischer et al.   NATURE IMMUNOLOGY

Proline-Rich Cytokine from Neurosecretory Granules: A New Natural Substrate for Dipeptidyl Peptidase IV

(2010) Alvard A. Antonyan et al.   NEUROCHEMICAL RESEARCH

Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes

(2010) N. J. Smith et al.   PHARMACOLOGICAL REVIEWS

The dimeric transmembrane domain of prolyl dipeptidase DPP-IV contributes to its quaternary structure and enzymatic activities

(2010) Kuei-Min Chung et al.   PROTEIN SCIENCE

Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist–antagonist binding modulation

(2009) Vicent Casadó et al.   BIOCHEMICAL PHARMACOLOGY

Structural and Metabolic Specificity of Methylthiocoformycin for Malarial Adenosine Deaminases

(2009) Meng-Chiao Ho et al.   BIOCHEMISTRY

How I treat ADA deficiency

(2009) H. B. Gaspar et al.   BLOOD

On the origin of serum CD26 and its altered concentration in cancer patients

(2009) Oscar J. Cordero et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Adenosine signaling and function in glial cells

(2009) D Boison et al.   CELL DEATH AND DIFFERENTIATION

The activity and expression of NTPDase is altered in lymphocytes of multiple sclerosis patients

(2009) Roselia M. Spanevello et al.   CLINICA CHIMICA ACTA

Dipeptidyl Peptidase-4 (CD26): Knowing the Function before Inhibiting the Enzyme

(2009) E. Matteucci et al.   CURRENT MEDICINAL CHEMISTRY

Oligomerization of G-protein-coupled receptors: A reality

(2009) Sergi Ferré et al.   CURRENT OPINION IN PHARMACOLOGY

Dimerization in GPCR mobility and signaling

(2009) Martin J Lohse   CURRENT OPINION IN PHARMACOLOGY

Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer

(2009) Juan José Fung et al.   EMBO JOURNAL

Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activation

(2009) José M. Martinez-Navio et al.   IMMUNOLOGY

Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV

(2009) Núria Climent et al.   IMMUNOLOGY AND CELL BIOLOGY

Generation and Accumulation of Immunosuppressive Adenosine by Human CD4+CD25highFOXP3+Regulatory T Cells

(2009) Magis Mandapathil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purification and Functional Reconstitution of Monomeric μ-Opioid Receptors

(2009) Adam J. Kuszak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardioprotection Induced by Adenosine A1 Receptor Agonists in a Cardiac Cell Ischemia Model Involves Cooperative Activation of Adenosine A2A and A2B Receptors by Endogenous Adenosine

(2009) Vijay B Urmaliya et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Exploiting the Pyrazolo[3,4-d]pyrimidin-4-one Ring System as a Useful Template To Obtain Potent Adenosine Deaminase Inhibitors

(2009) Concettina La Motta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric Modulators of the Adenosine A1Receptor: Synthesis and Pharmacological Evaluation of 4-Substituted 2-Amino-3-benzoylthiophenes

(2009) Luigi Aurelio et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activities of the enzymes that hydrolyze adenine nucleotides in platelets from multiple sclerosis patients

(2009) Roselia Maria Spanevello et al.   JOURNAL OF NEUROLOGY

Building a new conceptual framework for receptor heteromers

(2009) Sergi Ferré et al.   Nature Chemical Biology

A new ethyladenine antagonist of adenosine A2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug

(2009) Annalisa Pinna et al.   NEUROPHARMACOLOGY

Adenosine, adenosine A2A antagonists, and Parkinson's disease

(2009) P. Jenner et al.   PARKINSONISM & RELATED DISORDERS

GPCR homomers and heteromers: A better choice as targets for drug development than GPCR monomers?

(2009) Vicent Casadó et al.   PHARMACOLOGY & THERAPEUTICS

A2B adenosine receptors in immunity and inflammation

(2009) György Haskó et al.   TRENDS IN IMMUNOLOGY

Conformational change of adenosine deaminase during ligand-exchange in a crystal

(2008) Takayoshi Kinoshita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adenosine receptors and asthma

(2008) R A Brown et al.   BRITISH JOURNAL OF PHARMACOLOGY

Human N6-Methyl-AMP/DAMP Aminohydrolase (Abacavir 5'-Monophosphate Deaminase) is Capable of Metabolizing N6-Substituted Purine Acyclic Nucleoside Phosphonates

(2008) Markéta Schinkmanová et al.   COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS

A2A Adenosine Receptor and its Modulators: Overview on a Druggable GPCR and on Structure-Activity Relationship Analysis and Binding Requirements of Agonists and Antagonists

(2008) G. Cristalli et al.   CURRENT PHARMACEUTICAL DESIGN

Potential Therapeutic Interest of Adenosine A2A Receptors in Psychiatric Disorders

(2008) Rodrigo Cunha et al.   CURRENT PHARMACEUTICAL DESIGN

A Critical Evaluation of Adenosine A2A Receptors as Potentially “Druggable” Targets in Huntingtons Disease

(2008) Patrizia Popoli et al.   CURRENT PHARMACEUTICAL DESIGN

Dopamine D2 receptors form higher order oligomers at physiological expression levels

(2008) Wen Guo et al.   EMBO JOURNAL

Fasciola gigantica: Purification and characterization of adenosine deaminase

(2008) Ehab M.M. Ali   EXPERIMENTAL PARASITOLOGY

A1adenosine receptor agonists and their potential therapeutic applications

(2008) Elfatih Elzein et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Potential role of adenosine A2A receptors in the treatment of schizophrenia

(2008) Jadwiga Wardas   Frontiers in Bioscience-Landmark

Reduced ligand affinity leads to an impaired function of the adenosine A2Areceptor of human granulocytes in sepsis

(2008) Simone Kreth et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Conditioning response to granulocyte colony-stimulating factor via the dipeptidyl peptidase IV-adenosine deaminase complex

(2008) Daniele Focosi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inhibition of Adenosine Deaminase by Analogues of Adenosine and Inosine, Incorporating a Common Heterocyclic Base, 4(7)-Amino-6(5)H-imidazo[4,5-d]pyridazin-7(4)one

(2008) Ravi K. Ujjinamatada et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structures of Substrate- and Inhibitor-Bound Adenosine Deaminase from a Human Malaria Parasite Show a Dramatic Conformational Change and Shed Light on Drug Selectivity

(2008) Eric T. Larson et al.   JOURNAL OF MOLECULAR BIOLOGY

Human adenosine deaminase as an allosteric modulator of human A1adenosine receptor: abolishment of negative cooperativity for [3H](R)-pia binding to the caudate nucleus

(2008) Eduard Gracia et al.   JOURNAL OF NEUROCHEMISTRY

Detection of heteromerization of more than two proteins by sequential BRET-FRET

(2008) Paulina Carriba et al.   NATURE METHODS

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE

Adenosine as a neuromodulator in neurological diseases

(2007) D BOISON   CURRENT OPINION IN PHARMACOLOGY

The role of CD26/dipeptidyl peptidase IV in cancer

(2007) Pamela et al.   Frontiers in Bioscience-Landmark