The Role of microRNAs in Alzheimer’s Disease and Their Therapeutic Potentials

Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways

(2017) John P. Cogswell et al.   JOURNAL OF ALZHEIMERS DISEASE

Anti-Amyloid-β Immunotherapy in Alzheimer's Disease: ACC-001 Clinical Trials Are Ongoing

(2017) J. Michael Ryan et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammation and NF-κB in Alzheimer's Disease and Diabetes

(2017) Ivica Granic et al.   JOURNAL OF ALZHEIMERS DISEASE

MiR-107 is Reduced in Alzheimer's Disease Brain Neocortex: Validation Study

(2017) Peter T. Nelson et al.   JOURNAL OF ALZHEIMERS DISEASE

RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?

(2016) Maggie L. Bobbin et al.   Annual Review of Pharmacology and Toxicology

Anti-microRNAs as Novel Therapeutic Agents in the Clinical Management of Alzheimer's Disease

(2016) Yuhai Zhao et al.   Frontiers in Neuroscience

Learning by Failing: Ideas and Concepts to Tackle γ-Secretases in Alzheimer's Disease and Beyond

(2015) Bart De Strooper et al.   Annual Review of Pharmacology and Toxicology

Current Practices in the Treatment of Alzheimer Disease: Where is the Evidence After the Phase III Trials?

(2015) Megan J. Ehret et al.   CLINICAL THERAPEUTICS

Molecular mechanisms linking amyloid β toxicity and Tau hyperphosphorylation in Alzheimer׳s disease

(2015) A. Lloret et al.   FREE RADICAL BIOLOGY AND MEDICINE

miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregationin vivo

(2015) Pascal Y. Smith et al.   HUMAN MOLECULAR GENETICS

The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central A  Pharmacodynamic Responses in Mice, Dogs, and Humans

(2015) P. C. May et al.   JOURNAL OF NEUROSCIENCE

Solanezumab—prospects for meaningful interventions in AD?

(2015) Sam Gandy et al.   Nature Reviews Neurology

Immunotherapeutic Approaches for Alzheimer’s Disease

(2015) Thomas Wisniewski et al.   NEURON

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

Evidence for a neuroprotective microRNA pathway in amnestic mild cognitive impairment

(2015) Rebecca B. Weinberg et al.   Frontiers in Neuroscience

2014 Alzheimer's disease facts and figures

(2014)   Alzheimers & Dementia

Expression of Amyloid-Associated miRNAs in Both the Forebrain Cortex and Hippocampus of Middle-Aged Rat

(2014) Hui Che et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

microRNA-9 attenuates amyloidβ-induced synaptotoxicity by targeting calcium/calmodulin-dependent protein kinase kinase 2

(2014) FEI CHANG et al.   Molecular Medicine Reports

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Soluble Beta-Amyloid Peptides, but Not Insoluble Fibrils, Have Specific Effect on Neuronal MicroRNA Expression

(2014) Jing Jing Li et al.   PLoS One

The γ-secretase complex: from structure to function

(2014) Xian Zhang et al.   Frontiers in Cellular Neuroscience

The p53/miR-34 axis in development and disease

(2014) M. Rokavec et al.   Journal of Molecular Cell Biology

Familial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site

(2014) Wen Chen et al.   Nature Communications

β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer’s disease

(2014) Kelly Willemijn Menting et al.   Frontiers in Aging Neuroscience

γ-Secretase inhibitors and modulators

(2013) Todd E. Golde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Alteration of the microRNA network during the progression of Alzheimer's disease

(2013) Pierre Lau et al.   EMBO Molecular Medicine

Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes

(2013) Emmette R. Hutchison et al.   GLIA

Deficiency of the E3 ubiquitin ligase TRIM2 in early-onset axonal neuropathy

(2013) E. Ylikallio et al.   HUMAN MOLECULAR GENETICS

Alternative polyadenylation and miR-34 family members regulate tau expression

(2013) John R. Dickson et al.   JOURNAL OF NEUROCHEMISTRY

Circulating miR-125b as a biomarker of Alzheimer's disease

(2013) Lin Tan et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

MicroRNAs in Alzheimer's disease: differential expression in hippocampus and cell-free cerebrospinal fluid

(2013) Mareike Müller et al.   NEUROBIOLOGY OF AGING

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

(2013) Georges Mairet-Coello et al.   NEURON

Functional microRNAs in Alzheimer’s disease and cancer: differential regulation of common mechanisms and pathway

(2013) Kelly N. Holohan et al.   Frontiers in Genetics

Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10

(2012) Regina Augustin et al.   BMC Medical Genetics

MicroRNA-195 downregulates Alzheimer's disease amyloid-β production by targeting BACE1

(2012) Hong-Can Zhu et al.   BRAIN RESEARCH BULLETIN

MicroRNA-153 Physiologically Inhibits Expression of Amyloid-β Precursor Protein in Cultured Human Fetal Brain Cells and Is Dysregulated in a Subset of Alzheimer Disease Patients

(2012) Justin M. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

(2012) Bengt Winblad et al.   LANCET NEUROLOGY

Regulation of Complement Factor H (CFH) by Multiple miRNAs in Alzheimer’s Disease (AD) Brain

(2012) Walter J. Lukiw et al.   MOLECULAR NEUROBIOLOGY

The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila

(2012) Nan Liu et al.   NATURE

Potential pitfalls in microRNA profiling

(2012) Pauline Chugh et al.   Wiley Interdisciplinary Reviews-RNA

MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9

(2011) Jurong Yang et al.   AGE

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Clifford R. Jack et al.   Alzheimers & Dementia

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

miR-29c regulates BACE1 protein expression

(2011) Yuanyuan Zong et al.   BRAIN RESEARCH

Type 2 Diabetes and Late-Onset Alzheimer’s Disease

(2011) D. Cheng et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

microRNA-34c is a novel target to treat dementias

(2011) Athanasios Zovoilis et al.   EMBO JOURNAL

NF-кB-regulated micro RNAs (miRNAs) in primary human brain cells

(2011) Walter J. Lukiw   EXPERIMENTAL NEUROLOGY

Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease

(2011) Hirosha Geekiyanage et al.   EXPERIMENTAL NEUROLOGY

miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis

(2011) A. J. Kole et al.   GENES & DEVELOPMENT

Up-regulation of NF-kB-sensitive miRNA-125b and miRNA-146a in metal sulfate-stressed human astroglial (HAG) primary cell cultures

(2011) Aileen I. Pogue et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Target Gene Repression Mediated by miRNAs miR-181c and miR-9 Both of Which Are Down-regulated by Amyloid-β

(2011) Nicole Schonrock et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

AMP-activated protein kinase: a potential player in Alzheimer’s disease

(2011) Antero Salminen et al.   JOURNAL OF NEUROCHEMISTRY

MicroRNA-137/181c Regulates Serine Palmitoyltransferase and In Turn Amyloid  , Novel Targets in Sporadic Alzheimer's Disease

(2011) H. Geekiyanage et al.   JOURNAL OF NEUROSCIENCE

Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells

(2011) Yuan Yuan Li et al.   NEUROSCIENCE LETTERS

The Role of miR-103 and miR-107 in Regulation of CDK5R1 Expression and in Cellular Migration

(2011) Silvia Moncini et al.   PLoS One

The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease

(2011) Marong Fang et al.   TOXICOLOGY LETTERS

Patterns of microRNA expression in normal and early Alzheimer’s disease human temporal cortex: white matter versus gray matter

(2010) Wang-Xia Wang et al.   ACTA NEUROPATHOLOGICA

miR-107 Regulates Granulin/Progranulin with Implications for Traumatic Brain Injury and Neurodegenerative Disease

(2010) Wang-Xia Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

MicroRNA-101 downregulates Alzheimer’s amyloid-β precursor protein levels in human cell cultures and is differentially expressed

(2010) Justin M. Long et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Cerebrospinal Fluid Amyloid β42/40 Ratio in the Differentiation of Alzheimers Disease from Non-Alzheimers Dementia

(2010) P.E. Spies et al.   Current Alzheimer Research

MicroRNA-101 Regulates Amyloid Precursor Protein Expression in Hippocampal Neurons

(2010) Elisa Vilardo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-transcriptional Regulation of α-Synuclein Expression by mir-7 and mir-153

(2010) Epaminondas Doxakis   JOURNAL OF BIOLOGICAL CHEMISTRY

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs

(2010) Pascal Smith et al.   JOURNAL OF NEUROCHEMISTRY

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

Diabetes, Alzheimer disease, and vascular dementia: A population-based neuropathologic study

(2010) S. Ahtiluoto et al.   NEUROLOGY

Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3

(2010) M. Shioya et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Joint Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer's Disease Cortex Reveals Altered miRNA Regulation

(2010) Juan Nunez-Iglesias et al.   PLoS One

Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β

(2010) Nicole Schonrock et al.   PLoS One

MicroRNA-Related Cofilin Abnormality in Alzheimer's Disease

(2010) Jiaqi Yao et al.   PLoS One

miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation

(2009) Xiaoying Wang et al.   BRAIN RESEARCH BULLETIN

Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later

(2009) Alina Solomon et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein

(2009) Daosong Xu et al.   FASEB JOURNAL

APPandBACE1miRNA genetic variability has no major role in risk for Alzheimer disease

(2009) Karolien Bettens et al.   HUMAN MUTATION

Chromosome 21-derived MicroRNAs Provide an Etiological Basis for Aberrant Protein Expression in Human Down Syndrome Brains

(2009) Donald E. Kuhn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's disease: synaptic dysfunction and Aβ

(2009) Ganesh M Shankar et al.   Molecular Neurodegeneration

Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex

(2009) Prerna Sethi et al.   NEUROSCIENCE LETTERS

Memory and the NMDA Receptors

(2009) Fei Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

BH3-only proteins and their roles in programmed cell death

(2009) M Giam et al.   ONCOGENE

Repression of  -synuclein expression and toxicity by microRNA-7

(2009) E. Junn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

The atRA-responsive gene neuron navigator 2 functions in neurite outgrowth and axonal elongation

(2008) P.D. Muley et al.   Developmental Neurobiology

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Dysregulated microRNAs and their predicted targets associated with endometrioid endometrial adenocarcinoma in Hong Kong women

(2008) Tony K.H. Chung et al.   INTERNATIONAL JOURNAL OF CANCER

An NF-κB-sensitive Micro RNA-146a-mediated Inflammatory Circuit in Alzheimer Disease and in Stressed Human Brain Cells

(2008) Walter J. Lukiw et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

(2008) Philip Van Damme et al.   JOURNAL OF CELL BIOLOGY

Lack of Pathology in a Triple Transgenic Mouse Model of Alzheimer's Disease after Overexpression of the Anti-Apoptotic Protein Bcl-2

(2008) T. T. Rohn et al.   JOURNAL OF NEUROSCIENCE

The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of  -Site Amyloid Precursor Protein-Cleaving Enzyme 1

(2008) W.-X. Wang et al.   JOURNAL OF NEUROSCIENCE

Using hippocampal microRNA expression differences between mouse inbred strains to characterise miRNA function

(2008) Michael J. Parsons et al.   MAMMALIAN GENOME

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

(2008) S. S. Hebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA expression in the adult mouse central nervous system

(2008) M. Bak et al.   RNA

Identification of glucose-regulated miRNAs from pancreatic   cells reveals a role for miR-30d in insulin transcription

(2008) X. Tang et al.   RNA