Current Aspects of the Endocannabinoid System and Targeted THC and CBD Phytocannabinoids as Potential Therapeutics for Parkinson’s and Alzheimer’s Diseases: a Review

Microglial Phenotypes and Their Relationship to the Cannabinoid System: Therapeutic Implications for Parkinson’s Disease

(2020) Rachel Kelly et al.   MOLECULES

Endocannabinoid Modulation of Microglial Phenotypes in Neuropathology

(2020) Mikiei Tanaka et al.   Frontiers in Neurology

Transcriptomic Analyses for Identification and Prioritization of Genes Associated With Alzheimer’s Disease in Humans

(2020) Yuchen Shi et al.   Frontiers in Bioengineering and Biotechnology

Open-Label, Multicenter, Phase III Extension Study of Idalopirdine as Adjunctive to Donepezil for the Treatment of Mild-Moderate Alzheimer’s Disease

(2019) Lutz Frölich et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting CB1 and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson’s Disease

(2019) Eva Martínez-Pinilla et al.   MOLECULAR NEUROBIOLOGY

Target Enzyme in Alzheimer’s Disease:Acetylcholinesterase Inhibitors

(2019) Mridula Saxena et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Design, synthesis and evaluation of a novel metal chelator as multifunctional agents for the treatment of Alzheimer’s disease

(2019) Yingying Wang et al.   BIOORGANIC CHEMISTRY

Neuro-inflammation and anti-inflammatory treatment options for Alzheimer's disease

(2019) Tomris Ozben et al.   CLINICAL BIOCHEMISTRY

Role of endocannabinoid system in dopamine signalling within the reward circuits affected by chronic pain

(2019) Jakub Mlost et al.   PHARMACOLOGICAL RESEARCH

ABHD6: Its Place in Endocannabinoid Signaling and Beyond

(2019) Jessica K. Cao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis

(2019) B. Teter et al.   NEUROBIOLOGY OF DISEASE

Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System

(2018) Shana M. Augustin et al.   ACS Chemical Neuroscience

Detrimental effects of 2-arachidonoylglycerol on whole blood platelet aggregation and on cerebral blood flow after a focal ischemic insult in rats

(2018) Jennifer A. Shearer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Understanding Miro GTPases: Implications in the Treatment of Neurodegenerative Disorders

(2018) Laura Kay et al.   MOLECULAR NEUROBIOLOGY

Repurposing sex steroids and related drugs as potential treatment for Parkinson's disease

(2018) Mélanie Bourque et al.   NEUROPHARMACOLOGY

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron

(2018) Stephen D. Skaper et al.   Frontiers in Cellular Neuroscience

Application of Metabolomics in Alzheimer’s Disease

(2018) Jordan Maximillian Wilkins et al.   Frontiers in Neurology

Genetic polymorphisms of the endocannabinoid system in obesity and diabetes

(2018) Joseph M. Doris et al.   DIABETES OBESITY & METABOLISM

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism

(2018) Honghua Zheng et al.   Frontiers in Aging Neuroscience

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

(2017) Honghua Zheng et al.   JOURNAL OF NEUROSCIENCE

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Cannabinoid Receptor 2 Signaling in Neurodegenerative Disorders: From Pathogenesis to a Promising Therapeutic Target

(2017) Tommaso Cassano et al.   Frontiers in Neuroscience

In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease

(2017) Georgia Watt et al.   Frontiers in Pharmacology

Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study

(2016) Khalid A. Jadoon et al.   DIABETES CARE

Cannabinoid Receptor 2 Participates in Amyloid-β Processing in a Mouse Model of Alzheimer’s Disease but Plays a Minor Role in the Therapeutic Properties of a Cannabis-Based Medicine

(2016) Ester Aso et al.   JOURNAL OF ALZHEIMERS DISEASE

The Incidence of Parkinson's Disease: A Systematic Review and Meta-Analysis

(2016) Lauren Hirsch et al.   NEUROEPIDEMIOLOGY

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Cannabis sativa: The Plant of the Thousand and One Molecules

(2016) Christelle M. Andre et al.   Frontiers in Plant Science

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

(2015) Ross B. Mounsey et al.   EXPERIMENTAL NEUROLOGY

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

The neuroprotection of cannabidiol against MPP + -induced toxicity in PC12 cells involves trkA receptors, upregulation of axonal and synaptic proteins, neuritogenesis, and might be relevant to Parkinson's disease

(2015) Neife Aparecida Guinaim Santos et al.   TOXICOLOGY IN VITRO

Neuroprotective Potential of Adenosine A2Aand Cannabinoid CB1Receptor Antagonists in an Animal Model of Parkinson Disease

(2014) Silvia Cerri et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

(2014) Jason D Ulrich et al.   Molecular Neurodegeneration

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Systematic review: Efficacy and safety of medical marijuana in selected neurologic disorders: Report of the Guideline Development Subcommittee of the American Academy of Neurology

(2014) B. S. Koppel et al.   NEUROLOGY

N-Methyl D-Aspartate (NMDA) Receptor Antagonists and Memantine Treatment for Alzheimer’s Disease, Vascular Dementia and Parkinson’s Disease

(2013) David Olivares et al.   Current Alzheimer Research

Effect of cannabidiol in a MK-801-rodent model of aspects of Schizophrenia

(2011) Anand Gururajan et al.   BEHAVIOURAL BRAIN RESEARCH

Glia: Initiators and progressors of pathology in Parkinson's disease

(2011) Glenda M. Halliday et al.   MOVEMENT DISORDERS

Alzheimer's Disease

(2011) D. J. Selkoe   Cold Spring Harbor Perspectives in Biology

Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation

(2009) Javorina Milosevic et al.   Molecular Neurodegeneration

Mutation Analysis of the PINK1 Gene in 391 Patients With Parkinson Disease

(2008) Ryuya Kumazawa et al.   ARCHIVES OF NEUROLOGY

Enzymatic Pathways That Regulate Endocannabinoid Signaling in the Nervous System

(2008) Kay Ahn et al.   CHEMICAL REVIEWS

Pathophysiology of Parkinsonism

(2008) Adriana Galvan et al.   CLINICAL NEUROPHYSIOLOGY

Glial expression of cannabinoid CB2 receptors and fatty acid amide hydrolase are beta amyloid–linked events in Down’s syndrome

(2008) E. Núñez et al.   NEUROSCIENCE

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

(2008) J. E. Lauckner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Marijuana Neurobiology and Treatment

(2008) Ahmed Elkashef et al.   Substance Abuse

Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression

(2007) G Esposito et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats

(2007) Yannick Marchalant et al.   NEUROBIOLOGY OF AGING