Targeting CB1 and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson’s Disease

Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis

(2018) Jeremy D Hill et al.   BRITISH JOURNAL OF PHARMACOLOGY

Localization of the cannabinoid type-1 receptor in subcellular astrocyte compartments of mutant mouse hippocampus

(2018) Ana Gutiérrez-Rodríguez et al.   GLIA

Alterations in Gene and Protein Expression of Cannabinoid CB2 and GPR55 Receptors in the Dorsolateral Prefrontal Cortex of Suicide Victims

(2018) María S. García-Gutiérrez et al.   Neurotherapeutics

Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?

(2018) Fernanda F. Peres et al.   Frontiers in Pharmacology

History and future challenges of the subthalamic nucleus as surgical target: Review article

(2018) Jorge Guridi et al.   MOVEMENT DISORDERS

A putative lysophosphatidylinositol receptor GPR55 modulates hippocampal synaptic plasticity

(2017) Katrina Hurst et al.   HIPPOCAMPUS

Endocannabinoid system in neurodegenerative disorders

(2017) Balapal S. Basavarajappa et al.   JOURNAL OF NEUROCHEMISTRY

Crystal structures of agonist-bound human cannabinoid receptor CB1

(2017) Tian Hua et al.   NATURE

GPR55: A therapeutic target for Parkinson's disease?

(2017) Marta Celorrio et al.   NEUROPHARMACOLOGY

An Introduction to the Endogenous Cannabinoid System

(2016) Hui-Chen Lu et al.   BIOLOGICAL PSYCHIATRY

Crystal Structure of the Human Cannabinoid Receptor CB 1

(2016) Tian Hua et al.   CELL

High-resolution crystal structure of the human CB1 cannabinoid receptor

(2016) Zhenhua Shao et al.   NATURE

Biological characterization of PM226, a chromenoisoxazole, as a selective CB 2 receptor agonist with neuroprotective profile

(2016) M. Gómez-Cañas et al.   PHARMACOLOGICAL RESEARCH

Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration

(2016) Rita Valenzuela et al.   Cell Death & Disease

Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

(2016) Gemma Navarro et al.   Frontiers in Neuroscience

Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor

(2015) R B Laprairie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal models of Parkinson's disease: An updated overview

(2015) P. Gubellini et al.   REVUE NEUROLOGIQUE

Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism

(2014) Salvador Sierra et al.   Brain Structure & Function

CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum

(2014) E. Martínez-Pinilla et al.   EXPERIMENTAL NEUROLOGY

Neurotoxin-Induced Pathway Perturbation in Human Neuroblastoma SH-EP Cells

(2014) Jin Hwan Do   MOLECULES AND CELLS

Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor

(2014) Etienne Hebert-Chatelain et al.   Molecular Metabolism

Mitochondrial Diseases of the Brain

(2013) Rajnish K. Chaturvedi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anandamide-CB1 Receptor Signaling Contributes to Postnatal Ethanol-Induced Neonatal Neurodegeneration, Adult Synaptic, and Memory Deficits

(2013) S. Subbanna et al.   JOURNAL OF NEUROSCIENCE

Animal Models of Parkinson’s Disease: A Gateway to Therapeutics?

(2013) Weidong Le et al.   Neurotherapeutics

Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses

(2013) S. Sylantyev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Neuroanatomy of the Basal Ganglia

(2013) J. L. Lanciego et al.   Cold Spring Harbor Perspectives in Medicine

The Cannabinoid Receptor CB1 Modulates the Signaling Properties of the Lysophosphatidylinositol Receptor GPR55

(2012) Julia Kargl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial CB1 receptors regulate neuronal energy metabolism

(2012) Giovanni Bénard et al.   NATURE NEUROSCIENCE

Identification of the GPR55 Agonist Binding Site Using a Novel Set of High-Potency GPR55 Selective Ligands

(2011) Evangelia Kotsikorou et al.   BIOCHEMISTRY

Modulation of l-α-Lysophosphatidylinositol/GPR55 Mitogen-activated Protein Kinase (MAPK) Signaling by Cannabinoids

(2011) Sharon Anavi-Goffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Metabolic Control of Microtubule Dynamics Impairs the Autophagic Pathway in Parkinson’s Disease

(2011) S.M. Cardoso et al.   Neurodegenerative Diseases

GPR55 ligands promote receptor coupling to multiple signalling pathways

(2010) Christopher M Henstridge et al.   BRITISH JOURNAL OF PHARMACOLOGY

The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK

(2010) C Andradas et al.   ONCOGENE

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

(2008) István Katona et al.   NATURE MEDICINE

The diverse CB1and CB2receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin

(2007) R G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY