The adaptive immune response to Clostridioides difficile : A tricky balance between immunoprotection and immunopathogenesis

Considering the Immune System during Fecal Microbiota Transplantation for Clostridioides difficile Infection

(2020) Alyse L. Frisbee et al.   TRENDS IN MOLECULAR MEDICINE

Clostridium difficile Infection: An Epidemiology Update

(2020) Ana C. De Roo et al.   Clinics in Colon and Rectal Surgery

The Inflammasome and Type-2 Immunity in Clostridium difficile Infection

(2020) Alexandra Donlan et al.   Clinics in Colon and Rectal Surgery

IL-17–producing γδ T cells protect against Clostridium difficile infection

(2020) Yee-Shiuan Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic Association Reveals Protection against Recurrence of Clostridium difficile Infection with Bezlotoxumab Treatment

(2020) Judong Shen et al.   mSphere

Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate Clostridium difficile Colitis while Dysregulating the Inflammatory Response

(2019) Damian Maseda et al.   mBio

Status of vaccine research and development for Clostridium difficile

(2019) T.V. Riley et al.   VACCINE

Expert opinion on interleukin-12/23 and interleukin-23 antagonists as potential therapeutic options for the treatment of inflammatory bowel disease

(2019) Uni Wong et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection

(2019) Mahmoud M. Saleh et al.   Cell Host & Microbe

The IL-17 Family of Cytokines in Health and Disease

(2019) Mandy J. McGeachy et al.   IMMUNITY

The requirement for co-germinants during Clostridium difficile spore germination is influenced by mutations in yabG and cspA

(2019) Ritu Shrestha et al.   PLoS Pathogens

Clostridium (Clostridioides) difficile shedding by polar bears (Ursus maritimus) in the Canadian Arctic

(2019) J Scott Weese et al.   ANAEROBE

IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection

(2019) Alyse L. Frisbee et al.   Nature Communications

Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity

(2019) Li Wang et al.   Journal of Immunology Research

Characterization of the Immune Response during Infection Caused by Clostridioides difficile

(2019) Hamo et al.   Microorganisms

Randomised clinical trial: faecal microbiota transplantation by colonoscopy plus vancomycin for the treatment of severe refractory Clostridium difficile infection-single versus multiple infusions

(2018) G. Ianiro et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Neutralization of macrophage migration inhibitory factor improves host survival after Clostridium difficile infection

(2018) Shinsmon Jose et al.   ANAEROBE

Hierarchical recognition of amino acid co-germinants during Clostridioides difficile spore germination

(2018) Ritu Shrestha et al.   ANAEROBE

New insights into transmission of Clostridium difficile infection—narrative review

(2018) A. Durovic et al.   CLINICAL MICROBIOLOGY AND INFECTION

Systemic Inflammatory Responses in Ulcerative Colitis Patients and Clostridium difficile Infection

(2018) Julajak Limsrivilai et al.   DIGESTIVE DISEASES AND SCIENCES

Clostridium difficile colitis and zoonotic origins—a narrative review

(2018) Alexander W W Brown et al.   Gastroenterology Report

Toxin-positiveClostridium difficilelatently infect mouse colonies and protect against highly pathogenicC. difficile

(2017) Lucie Etienne-Mesmin et al.   GUT

Functional and phenotypic heterogeneity of group 3 innate lymphoid cells

(2017) Felipe Melo-Gonzalez et al.   IMMUNOLOGY

Distinguishing Clostridium difficile Recurrence From Reinfection: Independent Validation of Current Recommendations

(2017) Ana Durovic et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

IL-27/IL-27 Receptor Signaling Provides Protection in Clostridium difficile-Induced Colitis

(2017) Lifang Wang et al.   JOURNAL OF INFECTIOUS DISEASES

Clostridium difficile flagellin FliC: Evaluation as adjuvant and use in a mucosal vaccine against Clostridium difficile

(2017) Jean-François Bruxelle et al.   PLoS One

T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP

(2017) Lisa Perruzza et al.   Cell Reports

IL-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis

(2016) Carlo De Salvo et al.   AMERICAN JOURNAL OF PATHOLOGY

Induction of antitoxin responses in Clostridium-difficile-infected patients compared to healthy blood donors

(2016) Alice von Eichel-Streiber et al.   ANAEROBE

The microbiota and immune response during Clostridium difficile infection

(2016) Erica L. Buonomo et al.   ANAEROBE

Neutrophil-mediated inflammation in the pathogenesis of Clostridium difficile infections

(2016) Shinsmon Jose et al.   ANAEROBE

Interaction of gut microbiota with bile acid metabolism and its influence on disease states

(2016) Christopher Staley et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

IL-17+ CD8+ T cells: Differentiation, phenotype and role in inflammatory disease

(2016) Ushani Srenathan et al.   IMMUNOLOGY LETTERS

Coordination between T helper cells, iNKT cells, and their follicular helper subsets in the humoral immune response against Clostridium difficile toxin B

(2016) Pragya Rampuria et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Endogenous IL-17 as a factor determining the severity of Clostridium difficile infection in mice

(2016) Tomoaki Nakagawa et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Clostridium difficile colitis: pathogenesis and host defence

(2016) Michael C. Abt et al.   NATURE REVIEWS MICROBIOLOGY

Septins guide microtubule protrusions induced by actin-depolymerizing toxins likeClostridium difficiletransferase (CDT)

(2016) Thilo Nölke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A subpopulation of high IL-21-producing CD4+ T cells in Peyer’s Patches is induced by the microbiota and regulates germinal centers

(2016) Leigh Jones et al.   Scientific Reports

Microbiota-Regulated IL-25 Increases Eosinophil Number to Provide Protection during Clostridium difficile Infection

(2016) Erica L. Buonomo et al.   Cell Reports

Burden of Six Healthcare-Associated Infections on European Population Health: Estimating Incidence-Based Disability-Adjusted Life Years through a Population Prevalence-Based Modelling Study

(2016) Alessandro Cassini et al.   PLOS MEDICINE

The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia

(2016) Carrie A. Cowardin et al.   Nature Microbiology

Human Clostridium difficile infection: altered mucus production and composition

(2015) Melinda A. Engevik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The non-toxigenic Clostridium difficile CD37 protects mice against infection with a BI/NAP1/027 type of C. difficile strain

(2015) Keshan Zhang et al.   ANAEROBE

Treatment of Recurrent and SevereClostridium DifficileInfection

(2015) J.J. Keller et al.   Annual Review of Medicine

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

(2015) Teruyuki Sano et al.   CELL

Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection

(2015) Michael C. Abt et al.   Cell Host & Microbe

MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health

(2015) Jason L. Kubinak et al.   Cell Host & Microbe

The gut microbiota and host health: a new clinical frontier

(2015) Julian R Marchesi et al.   GUT

Interleukin-23 (IL-23), independent of IL-17 and IL-22, drives neutrophil recruitment and innate inflammation duringClostridium difficilecolitis in mice

(2015) Andrew J. McDermott et al.   IMMUNOLOGY

Outcomes of Clostridium difficile Infection in Hospitalized Leukemia Patients: A Nationwide Analysis

(2015) Ruihong Luo et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Burden of Clostridium difficile Infection in the United States

(2015) Fernanda C. Lessa et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systems Modeling of Interactions between Mucosal Immunity and the Gut Microbiome during Clostridium difficile Infection

(2015) Andrew Leber et al.   PLoS One

Clostridium difficile: New Insights into the Evolution of the Pathogenicity Locus

(2015) Marc Monot et al.   Scientific Reports

Disruption of the Gut Microbiome: Clostridium difficile Infection and the Threat of Antibiotic Resistance

(2015) Priscilla Johanesen et al.   Genes

Colonic Immunopathogenesis of Clostridium difficile Infections

(2014) Charles Darkoh et al.   Clinical and Vaccine Immunology

Clinical characteristics of relapses and re-infections in Clostridium difficile infection

(2014) J. Kim et al.   CLINICAL MICROBIOLOGY AND INFECTION

Interleukin-22 Regulates the Complement System to Promote Resistance against Pathobionts after Pathogen-Induced Intestinal Damage

(2014) Mizuho Hasegawa et al.   IMMUNITY

Persistence and Toxin Production by Clostridium difficile within Human Intestinal Organoids Result in Disruption of Epithelial Paracellular Barrier Function

(2014) Jhansi L. Leslie et al.   INFECTION AND IMMUNITY

Host Immunity to Clostridium difficile PCR Ribotype 017 Strains

(2014) Nazila V. Jafari et al.   INFECTION AND IMMUNITY

Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens

(2014) Theresa L. Geiger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tryptophan Catabolism Restricts IFN-γ–Expressing Neutrophils andClostridium difficileImmunopathology

(2014) Mohamad El-Zaatari et al.   JOURNAL OF IMMUNOLOGY

Clostridium difficile recurrence is characterized by pro-inflammatory peripheral blood mononuclear cell (PBMC) phenotype

(2014) M. B. Yacyshyn et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Surface layer proteins isolated from Clostridium difficile induce clearance responses in macrophages

(2014) Laura E. Collins et al.   MICROBES AND INFECTION

Focused specificity of intestinal TH17 cells towards commensal bacterial antigens

(2014) Yi Yang et al.   NATURE

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

(2014) Eliah R. Shamir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Systemic Inflammatory Response to Clostridium difficile Infection

(2014) Krishna Rao et al.   PLoS One

Risk factors for recurrentClostridium difficileinfection in hematopoietic stem cell transplant recipients

(2014) A.M. Huang et al.   Transplant Infectious Disease

Nontoxigenic Clostridium difficile Protects Hamsters against Challenge with Historic and Epidemic Strains of Toxigenic BI/NAP1/027 C. difficile

(2013) Kristin J. Nagaro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of Interleukin 23 Signaling in Clostridium difficile Colitis

(2013) Erica L. Buonomo et al.   JOURNAL OF INFECTIOUS DISEASES

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Clostridium difficile Modulates Host Innate Immunity via Toxin-Independent and Dependent Mechanism(s)

(2013) Nazila V. Jafari et al.   PLoS One

Epidemiology of Community-AssociatedClostridium difficileInfection, 2009 Through 2011

(2013) Amit S. Chitnis et al.   JAMA Internal Medicine

Efficacy of LFF571 in a Hamster Model of Clostridium difficile Infection

(2012) Anna Trzasko et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clostridium difficile infection in the community: a zoonotic disease?

(2012) M.P.M. Hensgens et al.   CLINICAL MICROBIOLOGY AND INFECTION

Immunization strategies forClostridium difficileinfections

(2012) Fabien Rebeaud et al.   Expert Review of Vaccines

Induction of cytokines in a macrophage cell line by proteins ofClostridium difficile

(2012) Prerna Vohra et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Critical Role for MyD88-Mediated Neutrophil Recruitment during Clostridium difficile Colitis

(2012) Irene Jarchum et al.   INFECTION AND IMMUNITY

Protective Role of Commensals against Clostridium difficile Infection via an IL-1 -Mediated Positive-Feedback Loop

(2012) M. Hasegawa et al.   JOURNAL OF IMMUNOLOGY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Clostridium difficile Spore-Macrophage Interactions: Spore Survival

(2012) Daniel Paredes-Sabja et al.   PLoS One

Targeted Restoration of the Intestinal Microbiota with a Simple, Defined Bacteriotherapy Resolves Relapsing Clostridium difficile Disease in Mice

(2012) Trevor D. Lawley et al.   PLoS Pathogens

Comparison of the Burdens of Hospital-Onset, Healthcare Facility-Associated Clostridium difficile Infection and of Healthcare-Associated Infection due to Methicillin-Resistant Staphylococcus aureus in Community Hospitals

(2011) Becky A. Miller et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Nucleotide-Binding Oligomerization Domain 1 Mediates Recognition of Clostridium difficile and Induces Neutrophil Recruitment and Protection against the Pathogen

(2011) M. Hasegawa et al.   JOURNAL OF IMMUNOLOGY

Identification and characterization of two bile acid coenzyme A transferases fromClostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium

(2011) Jason M. Ridlon et al.   JOURNAL OF LIPID RESEARCH

The host immune response to Clostridium difficile

(2011) C. P. Kelly et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Bacterial strain-specific induction of Foxp3+T regulatory cells is protective in murine allergy models

(2010) A. Lyons et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease

(2010) Reiko M. Onishi et al.   IMMUNOLOGY

Treatment with Monoclonal Antibodies againstClostridium difficileToxins

(2010) Israel Lowy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

(2010) N. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

(2010) Y. K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of broad- and narrow-spectrum antimicrobials on Clostridium difficile and microbial diversity in a model of the distal colon

(2010) M. C. Rea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Evidence for a cross-talk between human neutrophils and Th17 cells

(2009) M. Pelletier et al.   BLOOD

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

European Society of Clinical Microbiology and Infectious Diseases (ESCMID): treatment guidance document for Clostridium difficile infection (CDI)

(2009) M.P. Bauer et al.   CLINICAL MICROBIOLOGY AND INFECTION

IL-17-producing γδ T cells

(2009) Rebecca L. O'Brien et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses

(2009) Harumichi Ishigame et al.   IMMUNITY

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

(2009) Valérie Gaboriau-Routhiau et al.   IMMUNITY

Low counts of Faecalibacterium prausnitzii in colitis microbiota

(2009) H. Sokol et al.   INFLAMMATORY BOWEL DISEASES

Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI)

(2009) Brett A. Leav et al.   VACCINE

Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion

(2008) C. Chizzolini et al.   BLOOD

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune Responses

(2008) Jason A. Hall et al.   IMMUNITY

Bile Salts and Glycine as Cogerminants for Clostridium difficile Spores

(2008) J. A. Sorg et al.   JOURNAL OF BACTERIOLOGY

Decreased Diversity of the Fecal Microbiome in RecurrentClostridium difficile–Associated Diarrhea

(2008) Ju Young Chang et al.   JOURNAL OF INFECTIOUS DISEASES

Clostridium difficile TxAC314 and SLP-36kDa enhance the immune response toward a co-administered antigen

(2008) P. Brun et al.   JOURNAL OF MEDICAL MICROBIOLOGY