A novel role of breast cancer-derived hyaluronan on inducement of M2-like tumor-associated macrophages formation

High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer

(2015) Satu Tiainen et al.   HISTOPATHOLOGY

Regulation of PHLDA1 Expression by JAK2-ERK1/2-STAT3 Signaling Pathway

(2015) Ji Hyo Lyu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

COX/mPGES-1/PGE2pathway depicts an inflammatory-dependent high-risk neuroblastoma subset

(2015) Karin Larsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD44 clustering is involved in monocyte differentiation

(2014) Guoliang Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation

(2014) Simona Hefetz-Sela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10-Dependent M2 Polarization of Tumor-Associated Macrophages

(2013) J.-H. Lee et al.   CANCER RESEARCH

The hyaluronan synthesis inhibitor 4-methylumbelliferone exhibits antitumor effects against mesenchymal-like canine mammary tumor cells

(2013) TERUYOSHI SAITO et al.   Oncology Letters

The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients

(2012) Catharina Medrek et al.   BMC CANCER

The High and Low Molecular Weight Forms of Hyaluronan Have Distinct Effects on CD44 Clustering

(2012) Cuixia Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-Associated Microglia/Macrophages Enhance the Invasion of Glioma Stem-like Cells via TGF- 1 Signaling Pathway

(2012) X.-z. Ye et al.   JOURNAL OF IMMUNOLOGY

Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity

(2012) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3

(2011) Jingqi Chen et al.   CANCER CELL

Heat Shock Protein 27 Differentiates Tolerogenic Macrophages That May Support Human Breast Cancer Progression

(2011) Sanjib Banerjee et al.   CANCER RESEARCH

Hyaluronan Synthase HAS2 Promotes Tumor Progression in Bone by Stimulating the Interaction of Breast Cancer Stem-Like Cells with Macrophages and Stromal Cells

(2011) H. Okuda et al.   CANCER RESEARCH

Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase

(2011) C.E. Clarkin et al.   MATRIX BIOLOGY

Hyaluronan as an Immune Regulator in Human Diseases

(2011) Dianhua Jiang et al.   PHYSIOLOGICAL REVIEWS

Inflammatory Alterations of the Extracellular Matrix in the Tumor Microenvironment

(2011) Junko Iijima et al.   Cancers

Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization

(2010) N. Kobayashi et al.   CANCER RESEARCH

Constitutively Active Stat3 Enhances Neu-Mediated Migration and Metastasis in Mammary Tumors via Upregulation of Cten

(2010) I. Barbieri et al.   CANCER RESEARCH

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

CD44-ligation induces, through ERK1/2 pathway, synthesis of cytokines TNF-α and IL-6 required for differentiation of THP-1 monoblastic leukemia cells

(2010) S Bourcier et al.   LEUKEMIA

The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1  in macrophages via sphingosine-1-phosphate and transforming growth factor- 

(2009) B. Herr et al.   BLOOD

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy

(2009) S. J. Priceman et al.   BLOOD

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

SH2B1β enhances fibroblast growth factor 1 (FGF1)-induced neurite outgrowth through MEK-ERK1/2-STAT3-Egr1 pathway

(2009) Wei-Fan Lin et al.   CELLULAR SIGNALLING

Stimulation of Small Proteoglycan Synthesis by the Hyaluronan Synthesis Inhibitor 4-Methylumbelliferone in Human Skin Fibroblasts

(2009) Masaru Funahashi et al.   CONNECTIVE TISSUE RESEARCH

Transforming growth factor beta (TGF-β) and inflammation in cancer

(2009) Brian Bierie et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The effects of 4-methylumbelliferone on hyaluronan synthesis, MMP2 activity, proliferation, and motility of human aortic smooth muscle cells

(2009) D. Vigetti et al.   GLYCOBIOLOGY

Interleukin-10: new perspectives on an old cytokine

(2009) David M. Mosser et al.   IMMUNOLOGICAL REVIEWS

Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype

(2009) Andreas Weigert et al.   INTERNATIONAL JOURNAL OF CANCER

Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas

(2008) Y Komohara et al.   JOURNAL OF PATHOLOGY

Hyaluronan in human tumors: Pathobiological and prognostic messages from cell-associated and stromal hyaluronan

(2008) Raija H. Tammi et al.   SEMINARS IN CANCER BIOLOGY