Unconventional post-translational modifications in immunological signaling

Protein Arginine Methyltransferase 5 (PRMT5) Inhibition Induces Lymphoma Cell Death through Reactivation of the Retinoblastoma Tumor Suppressor Pathway and Polycomb Repressor Complex 2 (PRC2) Silencing

(2013) Jihyun Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromatin proteins and modifications as drug targets

(2013) Kristian Helin et al.   NATURE

Role of lysine methylation of NF- B in differential gene regulation

(2013) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin Topology and the Regulation of Antigen Receptor Assembly

(2012) Claudia Bossen et al.   Annual Review of Immunology

Transcriptional and Epigenetic Control of T Helper Cell Specification: Molecular Mechanisms Underlying Commitment and Plasticity

(2012) Yuka Kanno et al.   Annual Review of Immunology

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

(2012) John J. O'Shea et al.   IMMUNITY

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

Human Protein Arginine Methyltransferase 7 (PRMT7) Is a Type III Enzyme Forming ω-NG-Monomethylated Arginine Residues

(2012) Cecilia I. Zurita-Lopez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coactivator-Associated Arginine Methyltransferase 1 Regulates Fetal Hematopoiesis and Thymocyte Development

(2012) J. Li et al.   JOURNAL OF IMMUNOLOGY

ATP Induces Protein Arginine Deiminase 2-Dependent Citrullination in Mast Cells through the P2X7 Purinergic Receptor

(2012) S. Arandjelovic et al.   JOURNAL OF IMMUNOLOGY

A Method for Large-scale Identification of Protein Arginine Methylation

(2012) Thomas Uhlmann et al.   MOLECULAR & CELLULAR PROTEOMICS

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

(2012) Steve Eyre et al.   NATURE GENETICS

Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps

(2011) Nishant Dwivedi et al.   ARTHRITIS AND RHEUMATISM

Denitrosylation of S-nitrosylated OGT is triggered in LPS-stimulated innate immune response

(2011) In-Hyun Ryu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation

(2011) Fan Liu et al.   CANCER CELL

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming

(2011) Alex J. Kuo et al.   MOLECULAR CELL

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection

(2011) Saskia Hemmers et al.   PLoS One

The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells

(2010) E. Martinez-Garcia et al.   BLOOD

Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide

(2010) Mariano Redondo-Horcajo et al.   CARDIOVASCULAR RESEARCH

Disruption of Protein Arginine N -Methyltransferase 2 Regulates Leptin Signaling and Produces Leanness In Vivo Through Loss of STAT3 Methylation

(2010) Hiroaki Iwasaki et al.   CIRCULATION RESEARCH

The SNO-proteome: causation and classifications

(2010) Divya Seth et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells

(2010) K. B. O'Brien et al.   DEVELOPMENT

Foxo Transcription Factors Control Regulatory T Cell Development and Function

(2010) Yann M. Kerdiles et al.   IMMUNITY

Maintaining Cell Identity through Global Control of Genomic Organization

(2010) Gioacchino Natoli   IMMUNITY

Peptidylarginine Deiminase 2 Suppresses Inhibitory κB Kinase Activity in Lipopolysaccharide-stimulated RAW 264.7 Macrophages

(2010) Hye Jeong Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GATA Switches as Developmental Drivers

(2010) Emery H. Bresnick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Arginine methylation of the B cell antigen receptor promotes differentiation

(2010) Simona Infantino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transnitrosylation of XIAP Regulates Caspase-Dependent Neuronal Cell Death

(2010) Tomohiro Nakamura et al.   MOLECULAR CELL

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

(2010) Dan Levy et al.   NATURE IMMUNOLOGY

Structural profiling of endogenous S-nitrosocysteine residues reveals unique features that accommodate diverse mechanisms for protein S-nitrosylation

(2010) P.-T. Doulias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

(2010) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NIP45 controls the magnitude of the type 2 T helper cell response

(2010) John W. Fathman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational Mini-Review Series on Th17 Cells: Function and regulation of human T helper 17 cells in health and disease

(2009) S. Q. Crome et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Minireview: Protein Arginine Methylation of Nonhistone Proteins in Transcriptional Regulation

(2009) Young-Ho Lee et al.   MOLECULAR ENDOCRINOLOGY

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor

(2009) Yann M Kerdiles et al.   NATURE IMMUNOLOGY

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

(2009) Ronald S. Flannagan et al.   NATURE REVIEWS MICROBIOLOGY

Regulation of NF-κB activity through lysine monomethylation of p65

(2009) Chee-Kwee Ea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of NF- B by NSD1/FBXL11-dependent reversible lysine methylation of p65

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunity to Citrullinated Proteins in Rheumatoid Arthritis

(2008) Lars Klareskog et al.   Annual Review of Immunology

Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system

(2008) A. A. Musse et al.   Disease Models & Mechanisms

Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice

(2008) Jonathan A. Hill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities

(2008) Dorothy D Wood et al.   LABORATORY INVESTIGATION

Protein Arginine Methyltransferase 5 Suppresses the Transcription of the RB Family of Tumor Suppressors in Leukemia and Lymphoma Cells

(2008) L. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

(2008) Hart S Dengler et al.   NATURE IMMUNOLOGY

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

Acetylation of MKP-1 and the Control of Inflammation

(2008) H. Chi et al.   Science Signaling

Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination

(2008) Brian A Kidd et al.   ARTHRITIS RESEARCH & THERAPY

Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis

(2008) Xiaoyan Zhao et al.   ARTHRITIS RESEARCH & THERAPY