A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation

F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation

(2012) B. B. Chen et al.   BLOOD

FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest

(2011) Bill B. Chen et al.   CELL CYCLE

Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions

(2011) Joanne M. Hildebrand et al.   IMMUNOLOGICAL REVIEWS

Calmodulin Antagonizes a Calcium-Activated SCF Ubiquitin E3 Ligase Subunit, FBXL2, To Regulate Surfactant Homeostasis

(2011) B. B. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

F-box protein FBXL2 exerts human lung tumor suppressor-like activity by ubiquitin-mediated degradation of cyclin D3 resulting in cell cycle arrest

(2011) B B Chen et al.   ONCOGENE

Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile

(2010) Esther Lutgens et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

Calming the cytokine storm

(2010) Charlotte Harrison   NATURE REVIEWS DRUG DISCOVERY

Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza

(2010) N. R. London et al.   Science Translational Medicine

SnapShot: F Box Proteins I

(2009) Jeffrey R. Skaar et al.   CELL

Suppression of tumor necrosis factor receptor associated factor (TRAF)-2 attenuates the proinflammatory and proliferative effect of aggregated IgG on rat renal mesangial cells

(2009) Lang-Jing Zhu et al.   CYTOKINE

Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation

(2009) Shan Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

(2009) Ping-Hui Tseng et al.   NATURE IMMUNOLOGY

The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation

(2009) Peyman Nakhaei et al.   PLoS Pathogens

The RING Domain and First Zinc Finger of TRAF6 Coordinate Signaling by Interleukin-1, Lipopolysaccharide, and RANKL

(2008) Betty Lamothe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PML Activates Transcription by Protecting HIPK2 and p300 from SCFFbx3-Mediated Degradation

(2008) Y. Shima et al.   MOLECULAR AND CELLULAR BIOLOGY

c-Cbl-Dependent Monoubiquitination and Lysosomal Degradation of gp130

(2008) Y. Tanaka et al.   MOLECULAR AND CELLULAR BIOLOGY

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

(2008) Motozo Yamashita et al.   MOLECULAR CELL

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

(2008) Sivakumar Vallabhapurapu et al.   NATURE IMMUNOLOGY