EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability

EIF3H orchestrates Hippo pathway-mediated oncogenesis via catalytic control of YAP stability

(2020) Zhuan Zhou et al.   CANCER RESEARCH

USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail

(2019) Lei Li et al.   CANCER LETTERS

USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability

(2019) Maura Sonego et al.   Science Advances

Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma

(2018) Rui Zhu et al.   CANCER LETTERS

OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability

(2018) Honghong Zhou et al.   ONCOGENE

USP49 participates in the DNA damage response by forming a positive feedback loop with p53

(2018) Rongfu Tu et al.   Cell Death & Disease

Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation

(2018) Mana Taki et al.   Nature Communications

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

(2018) Junho Choe et al.   NATURE

PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359

(2018) Javier Rodriguez et al.   Cell Reports

TGFβ-Activated USP27X Deubiquitinase Regulates Cell Migration and Chemoresistance via Stabilization of Snail1

(2018) Guillem Lambies et al.   CANCER RESEARCH

Transforming Growth Factor-β Promotes Liver Tumorigenesis in Mice via Up-regulation of Snail

(2017) Hyuk Moon et al.   GASTROENTEROLOGY

A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1

(2017) Ji-Hyung Lee et al.   NATURE CELL BIOLOGY

SPSB3 targets SNAIL for degradation in GSK-3β phosphorylation-dependent manner and regulates metastasis

(2017) Y Liu et al.   ONCOGENE

Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1

(2017) Jun Wang et al.   Nature Communications

Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation

(2017) Yadi Wu et al.   Nature Communications

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1

(2017) Tongzheng Liu et al.   Nature Communications

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

(2017) Darshan S. Chandrashekar et al.   NEOPLASIA

Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9

(2017) Bae-Jung Choi et al.   Scientific Reports

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Elevated expression of eukaryotic translation initiation factor 3H is associated with proliferation, invasion and tumorigenicity in human hepatocellular carcinoma

(2016) Qian Zhu et al.   Oncotarget

FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development

(2015) Yue Jin et al.   CANCER LETTERS

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

(2015) Xin Ye et al.   TRENDS IN CELL BIOLOGY

The Role of Snail in EMT and Tumorigenesis

(2014) Yifan Wang et al.   CURRENT CANCER DRUG TARGETS

Cancer survival in China, 2003-2005: A population-based study

(2014) Hongmei Zeng et al.   INTERNATIONAL JOURNAL OF CANCER

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Esophageal Carcinoma

(2014) Anil K. Rustgi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

(2013) Chenfang Dong et al.   CANCER CELL

A siRNA screen identifies RAD21 , EIF3H , CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation

(2013) Sardar Faisal Mahmood et al.   CARCINOGENESIS

Oesophageal carcinoma

(2013) Arjun Pennathur et al.   LANCET

Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability

(2013) R. Vinas-Castells et al.   NUCLEIC ACIDS RESEARCH

Characterization of Gene-Environment Interactions for Colorectal Cancer Susceptibility Loci

(2012) C. M. Hutter et al.   CANCER RESEARCH

Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy

(2012) Hiroshi Okumura et al.   International Journal of Clinical Oncology

Epithelial–Mesenchymal Transition in Ovarian Carcinoma

(2012) Ben Davidson et al.   Frontiers in Oncology

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Regulation of p53 stability and function by the deubiquitinating enzyme USP42

(2011) Andreas K Hock et al.   EMBO JOURNAL

Which factors are associated with actual 5-year survival of oesophageal squamous cell carcinoma?

(2011) J. Liu et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Deubiquitinases in cancer: new functions and therapeutic options

(2011) J M Fraile et al.   ONCOGENE

MYC and EIF3H Coamplification Significantly Improve Response and Survival of Non-small Cell Lung Cancer Patients (NSCLC) Treated with Gefitinib

(2010) Federico Cappuzzo et al.   Journal of Thoracic Oncology

Allelic Variation at the 8q23.3 Colorectal Cancer Risk Locus Functions as a Cis-Acting Regulator of EIF3H

(2010) Alan M. Pittman et al.   PLoS Genetics

Cancer Metastasis Is Accelerated through Immunosuppression during Snail-Induced EMT of Cancer Cells

(2009) Chie Kudo-Saito et al.   CANCER CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The Hypoxia-controlled FBXL14 Ubiquitin Ligase Targets SNAIL1 for Proteasome Degradation

(2009) Rosa Viñas-Castells et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma

(2009) Ramin Massoumi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PCI Complexes: Beyond the Proteasome, CSN, and eIF3 Troika

(2009) Elah Pick et al.   MOLECULAR CELL

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

An Oncogenic Role for the Phosphorylated h-Subunit of Human Translation Initiation Factor eIF3

(2008) Lili Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY