Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1
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Title
Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1
Authors
Keywords
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Journal
Nature Communications
Volume 8, Issue 1, Pages -
Publisher
Springer Nature
Online
2017-12-14
DOI
10.1038/s41467-017-02243-3
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Note: Only part of the references are listed.- Cooperative Targets of Combined mTOR/HDAC Inhibition Promote MYC Degradation
- (2017) John K. Simmons et al. MOLECULAR CANCER THERAPEUTICS
- Snail controls proliferation of Drosophila ovarian epithelial follicle stem cells, independently of E-cadherin
- (2016) Chen-Yuan Tseng et al. DEVELOPMENTAL BIOLOGY
- Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development
- (2015) J. Pelletier et al. CANCER RESEARCH
- An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors
- (2015) Andrew T. Chang et al. GENES & DEVELOPMENT
- Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
- (2015) Xiaofeng Zheng et al. NATURE
- AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis
- (2015) Wenting Mi et al. Oncotarget
- Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail
- (2015) Weijia Cai et al. Oncotarget
- mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells
- (2015) Brandon R. Beagle et al. Oncotarget
- mTORC1/C2 and pan-HDAC inhibitors synergistically impair breast cancer growth by convergent AKT and polysome inhibiting mechanisms
- (2014) Kathleen A. Wilson-Edell et al. BREAST CANCER RESEARCH AND TREATMENT
- Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer
- (2014) Jian Shi et al. CANCER CELL
- The Role of Snail in EMT and Tumorigenesis
- (2014) Yifan Wang et al. CURRENT CANCER DRUG TARGETS
- Epigenetic Regulation of EMT: The Snail Story
- (2014) Yiwei Lin et al. CURRENT PHARMACEUTICAL DESIGN
- Oncogenic roles of EMT-inducing transcription factors
- (2014) Alain Puisieux et al. NATURE CELL BIOLOGY
- Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
- (2014) Katrina J. Falkenberg et al. NATURE REVIEWS DRUG DISCOVERY
- Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3
- (2014) N Robichaud et al. ONCOGENE
- Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer
- (2013) Chenfang Dong et al. CANCER CELL
- Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
- (2013) F. Ann Ran et al. CELL
- Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation
- (2013) Claire L. Cope et al. JOURNAL OF CELL SCIENCE
- The epigenetics of epithelial-mesenchymal plasticity in cancer
- (2013) Wai Leong Tam et al. NATURE MEDICINE
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors
- (2013) G S Ducker et al. ONCOGENE
- ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer
- (2013) Q Ye et al. ONCOGENE
- Pancreatic tumours escape from translational control through 4E-BP1 loss
- (2013) Y Martineau et al. ONCOGENE
- eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies
- (2012) T. Alain et al. CANCER RESEARCH
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Dual mTORC1/2 and HER2 Blockade Results in Antitumor Activity in Preclinical Models of Breast Cancer Resistant to Anti-HER2 Therapy
- (2012) C. Garcia-Garcia et al. CLINICAL CANCER RESEARCH
- The translational landscape of mTOR signalling steers cancer initiation and metastasis
- (2012) Andrew C. Hsieh et al. NATURE
- Anti-oncogenic potential of the eIF4E-binding proteins
- (2012) Y Martineau et al. ONCOGENE
- Genome Sequencing Identifies a Basis for Everolimus Sensitivity
- (2012) G. Iyer et al. SCIENCE
- mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways
- (2011) P. Gulhati et al. CANCER RESEARCH
- SNAI1 is Involved in the Proliferation and Migration of Glioblastoma Cells
- (2011) Sung-Pil Han et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Rapamycin passes the torch: a new generation of mTOR inhibitors
- (2011) Don Benjamin et al. NATURE REVIEWS DRUG DISCOVERY
- The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo
- (2010) G. Dasmahapatra et al. BLOOD
- Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E
- (2010) Andrew C. Hsieh et al. CANCER CELL
- 4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors
- (2010) Qing-Bai She et al. CANCER CELL
- Expression of Snail in Epidermal Keratinocytes Promotes Cutaneous Inflammation and Hyperplasia Conducive to Tumor Formation
- (2010) F. Du et al. CANCER RESEARCH
- mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs
- (2010) R. J. O. Dowling et al. SCIENCE
- AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity
- (2009) C. M. Chresta et al. CANCER RESEARCH
- Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
- (2009) Nahum Sonenberg et al. CELL
- Epithelial-Mesenchymal Transitions in Development and Disease
- (2009) Jean Paul Thiery et al. CELL
- Repression of PTEN Phosphatase by Snail1 Transcriptional Factor during Gamma Radiation-Induced Apoptosis
- (2008) M. Escriva et al. MOLECULAR AND CELLULAR BIOLOGY
- Breast Tumor Cells with PI3K Mutation or HER2 Amplification Are Selectively Addicted to Akt Signaling
- (2008) Qing-Bai She et al. PLoS One
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