Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability

(2016) D. R. Pattabiraman et al.   SCIENCE

Dub3 expression correlates with tumor progression and poor prognosis in human epithelial ovarian cancer

(2015) Bo Zhou et al.   BIOMEDICINE & PHARMACOTHERAPY

FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development

(2015) Yue Jin et al.   CANCER LETTERS

Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer

(2015) Ying Su et al.   Cell Reports

PKD1 Phosphorylation-Dependent Degradation of SNAIL by SCF-FBXO11 Regulates Epithelial-Mesenchymal Transition and Metastasis

(2014) Hanqiu Zheng et al.   CANCER CELL

CD151 represses mammary gland development by maintaining the niches of progenitor cells

(2014) Yuanqin Yin et al.   CELL CYCLE

A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells

(2014) S Thrane et al.   ONCOGENE

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

(2013) Chenfang Dong et al.   CANCER CELL

Pyrrolidine Dithiocarbamate Inhibits Herpes Simplex Virus 1 and 2 Replication, and Its Activity May Be Mediated through Dysregulation of the Ubiquitin-Proteasome System

(2013) M. Qiu et al.   JOURNAL OF VIROLOGY

High Dub3 Expression in Mouse ESCs Couples the G1/S Checkpoint to Pluripotency

(2013) Siem van der Laan et al.   MOLECULAR CELL

Multilayer control of the EMT master regulators

(2013) H Zheng et al.   ONCOGENE

Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

(2013) H. L. Silvestre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance

(2012) Dharminder Chauhan et al.   CANCER CELL

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

(2012) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer

(2012) Chenfang Dong et al.   JOURNAL OF CLINICAL INVESTIGATION

Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer

(2012) C Dong et al.   ONCOGENE

A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity

(2012) Nadine L. Samara et al.   STRUCTURE

Contribution of Active Site Residues to Substrate Hydrolysis by USP2: Insights into Catalysis by Ubiquitin Specific Proteases

(2011) Wanfang Zhang et al.   BIOCHEMISTRY

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

(2011) Mikael Altun et al.   CHEMISTRY & BIOLOGY

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

SwissDock, a protein-small molecule docking web service based on EADock DSS

(2011) A. Grosdidier et al.   NUCLEIC ACIDS RESEARCH

CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin–TGFβ signaling

(2011) P-K Lo et al.   ONCOGENE

Y-Box Binding Protein-1 Induces the Expression ofCD44andCD49fLeading to Enhanced Self-Renewal, Mammosphere Growth, and Drug Resistance

(2010) Karen To et al.   CANCER RESEARCH

CD44posCD49fhiCD133/2hi Defines Xenograft-Initiating Cells in Estrogen Receptor–Negative Breast Cancer

(2010) Matthew J. Meyer et al.   CANCER RESEARCH

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1

(2010) Yiwei Lin et al.   EMBO JOURNAL

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A

(2010) Yaron Pereg et al.   NATURE CELL BIOLOGY

Assessing compound binding to the Eg5 motor domain using a thermal shift assay

(2009) Patricia A. McDonnell et al.   ANALYTICAL BIOCHEMISTRY

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

(2009) Yadi Wu et al.   CANCER CELL

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The Hypoxia-controlled FBXL14 Ubiquitin Ligase Targets SNAIL1 for Proteasome Degradation

(2009) Rosa Viñas-Castells et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells

(2009) N J Sullivan et al.   ONCOGENE

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Small C-terminal Domain Phosphatase Enhances Snail Activity through Dephosphorylation

(2008) Yadi Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY