Article
Immunology
Joao Neves, Carolina Barroso, Pedro Carvalho, Magda Nunes, Jose F. M. Goncalves, Pedro N. S. Rodrigues
Summary: Erythroferrone is a red blood cell regulator produced in mammalian bone marrow and extramedullary sites. This study investigated its function in European sea bass and found that it responds to experimental anemia by increasing expression and suppressing hepcidin production, similar to mammals. However, during bacterial infection, Erythroferrone is downregulated while hepcidin levels increase.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Sung Yeon Ham, Ji Hae Jun, Hye-Bin Kim, Jae-Kwang Shim, Gisong Lee, Young-Lan Kwak
Summary: This study investigated the activities of key regulators affecting erythropoiesis in a rat model of iron deficiency anemia with inflammation. The results showed that IV iron therapy exacerbated inflammation and oxidative stress and did not resolve anemia.
Review
Pharmacology & Pharmacy
Poonam Sagar, Stanzin Angmo, Rajat Sandhir, Vikas Rishi, Hariom Yadav, Nitin Kumar Singhal
Summary: Iron is essential for mammals but its homeostasis must be accurately regulated for proper physiological functioning. Hepcidin plays a crucial role in maintaining iron balance in the body, while inflammatory disorders can disrupt this balance. Therapeutic approaches targeting the hepcidin-FPN axis have been developed to address iron-related disorders.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Nutrition & Dietetics
Branly Kilola Mbunga, Mala Ali Mapatano, Tor A. Strand, Elin Lovise F. Gjengedal, Pierre Zalagile Akilimali, Ingunn Marie S. Engebretsen
Summary: This study evaluated the prevalence of anemia and the role of iron deficiency in children in a malaria-endemic rural area. The results showed a high prevalence of anemia, with iron deficiency not significantly correlated with low hemoglobin levels. Major factors associated with anemia in the area included malaria, fever, and inflammatory conditions.
Review
Food Science & Technology
Mauricio Restrepo-Gallego, Luis E. Diaz, Patricia H. C. Rondo
Summary: Iron deficiency is the leading cause of anemia, and assessing iron nutritional status requires consideration of various laboratory tests and indicators. Using multiple indicators in combination may be the best practice due to the influence of different factors on these indicators. Constant validation, improvement of assessment methods, and identification of new indicators are key to refining the assessment of iron nutritional status and selecting appropriate treatment for improvement.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Medicine, Research & Experimental
Elizabeta Nemeth, Tomas Ganz
Summary: Hepcidin, secreted by hepatocytes, controls the activity of ferroportin to regulate plasma iron concentrations and total body iron content. Iron loading and inflammation increase hepcidin levels, while erythropoietic stimulation and pregnancy suppress its levels. Hepcidin deficiency leads to iron overload, while hepcidin excess causes iron-restrictive anemias. Developing hepcidin diagnostics and therapeutics will improve the treatment of iron disorders.
ANNUAL REVIEW OF MEDICINE
(2023)
Article
Medicine, General & Internal
Elena Buzzetti, Paolo Ventura, Elena Corradini
Summary: Iron is a trace element crucial for various vital processes, especially in heme synthesis. The role of iron in porphyrias remains debated due to conflicting results from clinical observations, in vitro studies and animal models. Testing for iron status and its metabolic pathways in patients with porphyrias can provide additional diagnostic and prognostic value for tailored management.
Article
Nutrition & Dietetics
Reagan M. Mogire, John Muthii Muriuki, Alireza Morovat, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson
Summary: There is a significant association between vitamin D and iron deficiency in African children. The risk of iron deficiency is increased in children with vitamin D deficiency, and vitamin D concentration variably influences iron status. Therefore, the link between vitamin D and iron status should be considered in strategies to manage these nutrient deficiencies.
Article
Multidisciplinary Sciences
Yael Ben-David, Ariel Koren, Raul Colodner, Carina Levin
Summary: Inflammatory states are associated with anemia caused by chronic disease and acute infection. Biochemical characteristics in children with anemia from different causes were investigated, and specific etiology-related profiles were identified using a combination of laboratory biomarkers, including hepcidin. Hepcidin levels were found to correlate with markers of inflammation and ferritin.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Peng Sun, Yueqin Zhou, Suhua Xu, Xiaotong Wang, Xiuxiu Li, Hailin Li, Zongyu Lin, Fenglian Huang, Lewei Zhu, Yanna Zhu
Summary: This study aimed to investigate the association between first-trimester maternal serum hepcidin and third-trimester iron deficiency anemia (IDA). The study found that higher levels of first-trimester hepcidin were negatively associated with the risk of third-trimester IDA, suggesting that elevated hepcidin may predict a reduced risk for developing IDA.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Hilde van der Staaij, Albertine E. Donker, Dirk L. Bakkeren, Jan M. J. I. Salemans, Lisette A. A. Mignot-Evers, Marlies Y. Bongers, Jeanne P. Dieleman, Tessel E. Galesloot, Coby M. Laarakkers, Siem M. Klaver, Dorine W. Swinkels
Summary: In this study, the TSAT/hepcidin ratio was found to be a useful tool for distinguishing IRIDA from IDA, with excellent performance in early diagnosis. This method helps identify IRIDA related to gene mutations, while recent iron therapy and moderate-to-severe inflammation should be excluded.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Carolina Thalya da Silva Paulino, Marislei Nishijima, Flavia Mori Sarti
Summary: Anemia prevalence among children under five in Brazil is high, with government iron supplementation programs showing significant effects on reducing hospitalizations and lengths of stay due to iron-deficiency anemia, especially in non-poor areas. The programs complement each other but do not influence mortality rates, indicating a need for operational improvements to achieve better outcomes in reducing severe iron-deficiency anemia among children under four.
Article
Surgery
Jong Wook Song, Sarah Soh, Jae-Kwang Shim, Sak Lee, Seung Hyun Lee, Hye Bin Kim, Min-Yu Kim, Young Lan Kwak
Summary: Intravenous iron supplementation during index hospitalization for complex cardiac surgery did not minimize packed erythrocytes transfusion, despite higher hemoglobin concentration and reticulocyte count in the iron group.
Article
Pharmacology & Pharmacy
Liuxiang Li, Xiaoxue Wang, Hongyu Zhang, Qingqing Chen, Huifei Cui
Summary: The study demonstrated that low anticoagulant heparin-iron significantly reduces anticoagulant activity, decreases hepcidin mRNA and IL-6 induced hepcidin levels in HepG2 cells, and lowers hepcidin expression through various pathways, leading to improved anemia in ACD mice with elevated serum hepcidin levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eryk Wacka, Edyta Wawrzyniak-Gramacka, Anna Tylutka, Barbara Morawin, Marzena Gutowicz, Agnieszka Zembron-Lacny
Summary: Aging-related anemia is associated with frailty syndrome, cognitive decline, and early mortality. This study aimed to assess the relationship between inflammaging and anemia as a prognostic indicator in older patients. The findings revealed lower levels of hematological variables and age-related iron deficiency in the anemic group. IL-1 beta was identified as a useful marker for identifying underlying causes of anemia, while CD34 and CD38 showed potential for compensatory response assessment and long-term monitoring in older adults.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Sant-Rayn Pasricha, Michael Gilbertson, Tishya Indran, Ashwini Bennett, Matthew van Dam, Elizabeth Coughlin, Anouk Dev, Sanjeev Chunilal, Stephen Opat
Summary: The study aimed to assess the safety and efficacy of administering undiluted, rapid ferric carboxymaltose injections in patients with iron-deficiency anaemia. The results showed that this method was well tolerated and led to improvements in hemoglobin levels, with some common mild adverse effects. Overall, patients were willing to receive this treatment again, indicating its potential for use in the ambulatory setting.
INTERNAL MEDICINE JOURNAL
(2021)
Review
Medicine, General & Internal
Sant-Rayn Pasricha, Jason Tye-Din, Martina U. Muckenthaler, Dorine W. Swinkels
Summary: Iron deficiency is a major contributor to the global burden of disease, particularly affecting children, premenopausal women, and those in low-income and middle-income countries. Oral iron therapy is usually the first line of treatment, but high-dose oral iron supplementation and iron absorption during inflammation may be limited by hepcidin upregulation.
Article
Pathology
James A. Kuzich, Sarah Heynemann, Niall Geoghegan, Cindy Evelyn, Susan O'Mahoney, Susan Wilson, Janine Campbell, Kelly Rogers, Benjamin Solomon, David Westerman, Sant-Rayn Pasricha
Summary: The study found that most patients treated with alectinib experienced red blood cell membrane abnormalities, with almost all patients developing anemia, though definite new hemolysis was present in only a few patients.
Review
Nutrition & Dietetics
Philip T. James, Zakari Ali, Andrew E. Armitage, Ana Bonell, Carla Cerami, Hal Drakesmith, Modou Jobe, Kerry S. Jones, Zara Liew, Sophie E. Moore, Fernanda Morales-Berstein, Helen M. Nabwera, Behzad Nadjm, Sant-Rayn Pasricha, Pauline Scheelbeek, Matt J. Silver, Megan R. Teh, Andrew M. Prentice
Summary: Malnutrition may impact susceptibility to and progression of COVID-19, with limited evidence on the effectiveness of high-dose micronutrient supplements in preventing severe disease or expediting recovery. Prevention of obesity and type 2 diabetes shows strong evidence in reducing the risk of serious COVID-19 outcomes.
JOURNAL OF NUTRITION
(2021)
Article
Multidisciplinary Sciences
Elisabeth Littwitz-Salomon, Diana Moreira, Joe N. Frost, Chloe Choi, Kevin T. Liou, David K. Ahern, Simon O'Shaughnessy, Bernd Wagner, Christine A. Biron, Hal Drakesmith, Ulf Dittmer, David K. Finlay
Summary: The study reveals that NK cells reprogram their metabolism by increasing nutrient uptake post-infection, especially amino acids and iron. Iron deficiency significantly impairs NK cell antiviral functions, leading to increased viral loads.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Hematology
Andrew E. Armitage, Hal Drakesmith
Summary: This study provides valuable insights into the dynamics of iron handling during the resolution of an inflammatory anemia by prospectively following patients with tuberculosis after treatment initiation.
Article
Multidisciplinary Sciences
Jon Wade, David J. Byrne, Chris J. Ballentine, Hal Drakesmith
Summary: This article discusses the important role of iron in the formation of planetary biospheres, planetary habitability, and the process of biological evolution. Changes in iron solubility caused by the increase in atmospheric oxygen after the Great Oxygenation Event have had an impact on biological evolution, making organisms more efficiently utilize this scarce but vital nutrient.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Dermatology
Hnin P. Oo, Sant-Rayn Pasricha, Bryony Thompson, Ingrid Winship, Laura Scardamaglia
Summary: This case report presents a successful treatment of a venous malformation due to a variant in the TEK gene using low dose rivaroxaban, effectively controlling symptoms of chronic localized intravascular coagulation.
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2022)
Article
Nutrition & Dietetics
Edifofon Akpan, Sheikh J. Hossain, Angela Devine, Sabine Braat, Mohammed Hasan, S. M. Mulk Uddin Tipu, Mohammad Saiful Alam Bhuiyan, Jena D. Hamadani, Beverley-Ann Biggs, Sant-Rayn Pasricha, Natalie Carvalho
Summary: This study assessed the cost-effectiveness of iron supplements and iron-containing multiple micronutrient powders (MNPs) among young children in rural Bangladesh. The results showed that iron supplementation was more cost-effective and averted more disability-adjusted life-years compared to MNPs. These findings do not support the universal use of iron supplementation or micronutrient powders as a cost-effective intervention for young children in rural Bangladesh.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Meeting Abstract
Hematology
Katherine L. Fielding, Sabine Braat, Eliza Davidson, Gemma Moir-Meyer, Sophie Zaloumis, Jessica Xu Hui Xu, Sophia M. Blaauwendraad, Vincent W. V. Jaddoe, Romy Gaillard, Patricia C. Parkin, Cornelia M. Borkhoff, Charles D. Keown-Stoneman, Catherine S. Birken, Jonathon L. Maguire, Sant-Rayn Pasricha
Meeting Abstract
Hematology
Danielle Clucas, Cavan Bennett, Ryan Steel, Ronan Mellin, Sabrina Caiazzo, Ute Schaeper, Justin Boddey, Ricardo Ataide, Sant-Rayn Pasricha
Meeting Abstract
Hematology
Sant-Rayn Pasricha, Martin Mwangi, Ernest Moya, Ricardo Ataide, Glory Mzembe, Rebecca Harding, Truwah Zinenani, Danielle Clucas, Sabine Braat, Kamija S. Phiri
Review
Multidisciplinary Sciences
Maria Nieves Garcia-Casal, Omar Dary, Maria Elena Jefferds, Sant-Rayn Pasricha
Summary: Accurate and affordable tools for diagnosing anemia and understanding its causes are crucial. This review focuses on hemoglobin measurement methods, equipment, and quality control, as well as other causes of anemia. It emphasizes the importance of correct diagnosis to avoid the costs of misdiagnosis. At both individual and public health levels, actions must be taken to diagnose and control anemia effectively.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Meeting Abstract
Hematology
Andrew J. Baldi, Sant-Rayn Pasricha, Aaron R. Jex, M. Imrul Hasan, Naomi Jones, Marilou Barrios, Sabine Braat, Jena Hamadani, Stephen Wilcox, Beverley-Ann Biggs, Rory Bowden
Article
Oncology
Toma S. Omofoye, Anganile Kalinga, Ramapriya Ganti, Frank J. Minja, Timothy B. Rooney
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Prarthna V. Bhardwaj, Renuka Dulala, Senthil Rajappa, Chandravathi Loke
Summary: The management of breast cancers in India needs greater emphasis on awareness, early detection, standard pathologic testing, and cost-effective solutions. With standardized management, outcomes similar to those of developed countries can be expected. Additionally, clinical trials aimed at a more diverse population in LMICs like India should be undertaken.
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Victoria E. Forbes, Mary D. Chamberlin, Vincent Dusabejambo, Tim Walker, Steve P. Bensen, Norrisa Haynes, Kathryn Nunes, Veauthyelau Saint-Joy, Frederick L. Makrauer
Summary: Global health education needs to adapt to the challenges we face, such as inequities and pandemics. Virtual teaching models are effective in delivering global health education and improving outcomes through bidirectional learning and equitable partnerships.
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Tefta Isufaj Haliti, Ilir Hoxha, Rubena Mojsiu, Rohini Mandal, Goksu Goc, Kreshnike Dedushi Hoti
Summary: The IOTA Simple Rules have high diagnostic performance in distinguishing between benign and malignant adnexal masses, providing a reliable tool for early diagnosis of ovarian cancer.
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Cecilia Felix Penido Mendes de Sousa, Jared Pasetsky, Gustavo Nader Marta, Megan Kassick, Fabio Ynoe Moraes, Luqman K. Dad
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Mary D. Chamberlin, Dafina Ademi Islami, Shqiptar Demaci, Richard J. Barth Jr
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Review
Oncology
Jeta Bunjaku, Arber Lama, Tawanda Pesanayi, Jeton Shatri, Mary Chamberlin, Ilir Hoxha
Summary: The evidence suggests that lifestyle factors such as alcohol and coffee intake may increase the risk of lung cancer, while tea intake may have a protective effect. However, the quality of evidence is currently low and further research is needed.
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Mary Chamberlin, Christopher Booth, Gabriel A. Brooks, Achille Manirakiza, Fidel Rubagumya, Verna Vanderpuye
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Anne Christine Buteau, Alicia Castelo-Loureiro, Regina Barragan-Carrillo, Suyapa Bejarano, Alba J. Kihn-Alarcon, Enrique Soto-Perez-de-Celis
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Review
Oncology
Ilir Hoxha, Fitim Sadiku, Lot Hoxha, Midhet Nasim, Marie Anne Christine Buteau, Krenare Grezda, Mary D. Chamberlin
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
