Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan

Regulatory Role of Proteasome in Determination of Platelet Life Span

(2013) Manasa K. Nayak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Developmental changes in human megakaryopoiesis

(2013) O. Bluteau et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Protein degradation systems in platelets

(2013) Bjoern F. Kraemer et al.   THROMBOSIS AND HAEMOSTASIS

Bcl-2, Bcl-xL, and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

(2012) D. Merino et al.   BLOOD

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

(2012) M. J. White et al.   BLOOD

Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes

(2011) Z.-J. Liu et al.   BLOOD

BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation

(2011) M. Vogler et al.   BLOOD

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

(2011) S. M. Schoenwaelder et al.   BLOOD

Neonatal and adult megakaryopoiesis

(2011) Zhi-Jian Liu et al.   CURRENT OPINION IN HEMATOLOGY

BH3-only Activator Proteins Bid and Bim Are Dispensable for Bak/Bax-dependent Thrombocyte Apoptosis Induced by Bcl-xL Deficiency

(2011) Takahiro Kodama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

(2011) Emma C. Josefsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I Interferon Drives Dendritic Cell Apoptosis via Multiple BH3-Only Proteins following Activation by PolyIC In Vivo

(2011) Silvia A. Fuertes Marraco et al.   PLoS One

Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development

(2010) P N Kelly et al.   CELL DEATH AND DIFFERENTIATION

Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis

(2010) J.-H. Klusmann et al.   GENES & DEVELOPMENT

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

(2010) Wyndham H Wilson et al.   LANCET ONCOLOGY

Differences between Newborn and Adult Mice in Their Response to Immune Thrombocytopenia

(2010) Zhongbo Hu et al.   Neonatology

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Critical role for ERK1/2 in bone marrow and fetal liver–derived primary megakaryocyte differentiation, motility, and proplatelet formation

(2009) Alexandra Mazharian et al.   EXPERIMENTAL HEMATOLOGY

Dual roles for hepatic lectin receptors in the clearance of chilled platelets

(2009) Viktoria Rumjantseva et al.   NATURE MEDICINE

Platelet reference ranges for neonates, defined using data from over 47 000 patients in a multihospital healthcare system

(2008) S E Wiedmeier et al.   Journal of Perinatology

Red Cell Volume Can Be Accurately Determined in Sheep Using a Nonradioactive Biotin Label

(2008) Donald M Mock et al.   PEDIATRIC RESEARCH