Essential in vivo roles of the platelet activation receptor CLEC-2 in tumour metastasis, lymphangiogenesis and thrombus formation

Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation

(2010) P. Uhrin et al.   BLOOD

CLEC-2 activates Syk through dimerization

(2010) C. E. Hughes et al.   BLOOD

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

(2010) C. C. Bertozzi et al.   BLOOD

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Platelets Play an Essential Role in Separating the Blood and Lymphatic Vasculatures During Embryonic Angiogenesis

(2010) Laura Carramolino et al.   CIRCULATION RESEARCH

Essentialin VivoRoles of the C-type Lectin Receptor CLEC-2

(2010) Katsue Suzuki-Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel mechanism of cytokine release in phagocytes induced by aggretin, a snake venom C-type lectin protein, through CLEC-2 ligation

(2010) C.-H. CHANG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

CLEC-2 is not required for platelet aggregation at arteriolar shear

(2010) C. E. HUGHES et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A mouse knockout library for secreted and transmembrane proteins

(2010) Tracy Tang et al.   NATURE BIOTECHNOLOGY

The Platelet Receptor CLEC-2 Is Active as a Dimer

(2009) Aleksandra A. Watson et al.   BIOCHEMISTRY

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

(2009) F. May et al.   BLOOD

CLEC-2 Is a Phagocytic Activation Receptor Expressed on Murine Peripheral Blood Neutrophils

(2009) A. M. Kerrigan et al.   JOURNAL OF IMMUNOLOGY

The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets

(2009) J. C. SPALTON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Renal cells activate the platelet receptor CLEC-2 through podoplanin

(2008) Charita M. Christou et al.   BIOCHEMICAL JOURNAL

Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity

(2008) N. C. Johnson et al.   GENES & DEVELOPMENT

Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice

(2008) Jianxin Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE

Platelet aggregation in the formation of tumor metastasis

(2008) Takashi TSURUO et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES