Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life

Effects of Fostamatinib (R788), an Oral Spleen Tyrosine Kinase Inhibitor, on Health-related Quality of Life in Patients with Active Rheumatoid Arthritis: Analyses of Patient-reported Outcomes from a Randomized, Double-blind, Placebo-controlled Trial

(2013) M. E. Weinblatt et al.   JOURNAL OF RHEUMATOLOGY

Mechanotransduction, PROX1, and FOXC2 Cooperate to Control Connexin37 and Calcineurin during Lymphatic-Valve Formation

(2012) Amélie Sabine et al.   DEVELOPMENTAL CELL

Platelet Activation Receptor CLEC-2 Regulates Blood/Lymphatic Vessel Separation by Inhibiting Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells

(2012) Makoto Osada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration

(2012) J Hoellenriegel et al.   LEUKEMIA

Hemostatic Properties of the Lymph: Relationships with Occlusion and Thrombosis

(2012) Giuseppe Lippi et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development

(2011) B. A. Finney et al.   BLOOD

Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves

(2011) R. S. Srinivasan et al.   GENES & DEVELOPMENT

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice

(2011) Eleni Bazigou et al.   JOURNAL OF CLINICAL INVESTIGATION

Platelets

(2010) Cara C. Bertozzi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation

(2010) P. Uhrin et al.   BLOOD

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

(2010) C. C. Bertozzi et al.   BLOOD

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Platelets Play an Essential Role in Separating the Blood and Lymphatic Vasculatures During Embryonic Angiogenesis

(2010) Laura Carramolino et al.   CIRCULATION RESEARCH

Essentialin VivoRoles of the C-type Lectin Receptor CLEC-2

(2010) Katsue Suzuki-Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

(2009) F. May et al.   BLOOD

Integrin-α9 Is Required for Fibronectin Matrix Assembly during Lymphatic Valve Morphogenesis

(2009) Eleni Bazigou et al.   DEVELOPMENTAL CELL

A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

(2009) Warwick S Nesbitt et al.   NATURE MEDICINE

Terminal Part of Thoracic Duct: High-Resolution US Imaging

(2009) Marcus Seeger et al.   RADIOLOGY

Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target

(2008) R. M. Young et al.   BLOOD

Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice

(2008) Jianxin Fu et al.   JOURNAL OF CLINICAL INVESTIGATION