Nicotinic Receptor Subunits Atlas in the Adult Human Lung

Using single-cell RNA sequencing to unravel cell lineage relationships in the respiratory tract

(2020) L.E. Zaragosi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The nicotinic receptor alpha5 coding polymorphism rs16969968 as a major target in disease: functional dissection and remaining challenges

(2020) Uwe Maskos   JOURNAL OF NEUROCHEMISTRY

Expression of the SARS-CoV-2 ACE2 Receptor in the Human Airway Epithelium

(2020) Haijun Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2

(2020) Guoshuai Cai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A hypothesis for pathobiology and treatment of COVID‐19 : The centrality of ACE1 / ACE2 imbalance

(2020) Krishna Sriram et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

COVID-19 and Smoking. Is Nicotine the Hidden Link?

(2020) Patrizia Russo et al.   EUROPEAN RESPIRATORY JOURNAL

GTS-21, an α7nAChR agonist, suppressed the production of key inflammatory mediators by PBMCs that are elevated in COPD patients and associated with impaired lung function

(2020) Sana Douaoui et al.   IMMUNOBIOLOGY

Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling

(2020) Roger L. Papke et al.   NEUROPHARMACOLOGY

E‐cigarettes, nicotine, the lung and the brain: multi‐level cascading pathophysiology

(2020) Melissa Herman et al.   JOURNAL OF PHYSIOLOGY-LONDON

Dissecting the genetic overlap of smoking behaviors, lung cancer, and chronic obstructive pulmonary disease: A focus on nicotinic receptors and nicotine metabolizing enzyme

(2020) Michael J. Bray et al.   GENETIC EPIDEMIOLOGY

Exaggerated BMP4 Signalling Alters Human Airway Basal Progenitor Cell Differentiation to Cigarette Smoking-related Phenotypes

(2019) Wu-Lin Zuo et al.   EUROPEAN RESPIRATORY JOURNAL

The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease

(2019) Herbert B Schiller et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Calcium influx through muscle nAChR-channels: One route, multiple roles

(2019) Francesca Grassi et al.   NEUROSCIENCE

A cellular census of human lungs identifies novel cell states in health and in asthma

(2019) Felipe A. Vieira Braga et al.   NATURE MEDICINE

Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures

(2019) Sandra Ruiz García et al.   DEVELOPMENT

α7-Nicotinic acetylcholine receptor antagonist QND7 suppresses non-small cell lung cancer cell proliferation and migration via inhibition of Akt/mTOR signaling

(2019) Wasita Witayateeraporn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nicotinic acetylcholine receptor at vertebrate motor endplates: Endocytosis, recycling, and degradation

(2019) Rüdiger Rudolf et al.   NEUROSCIENCE LETTERS

Identification of nicotinic acetylcholine receptor subunits in different lung cancer cell lines and the inhibitory effect of alpha-conotoxin TxID on lung cancer cell growth

(2019) Jiang Qian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Acetylcholine receptors: Key players in cancer development

(2019) Jiawei Chen et al.   SURGICAL ONCOLOGY-OXFORD

The wonderland of neuronal nicotinic acetylcholine receptors

(2018) Daniel Bertrand et al.   BIOCHEMICAL PHARMACOLOGY

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors

(2018) Michele Zoli et al.   Current Neuropharmacology

Alteration of primary cilia in COPD

(2018) Jeanne-Marie Perotin et al.   EUROPEAN RESPIRATORY JOURNAL

Ionotropic and Metabotropic Mechanisms of Allosteric Modulation ofα7 Nicotinic Receptor Intracellular Calcium

(2018) Justin R. King et al.   MOLECULAR PHARMACOLOGY

Beyond the Channel: Metabotropic Signaling by Nicotinic Receptors

(2018) Nadine Kabbani et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Nicotine and the Renin-Angiotensin System

(2018) Joshua M. Oakes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Oxidative stress responses in human bronchial epithelial cells exposed to cigarette smoke and vapor from tobacco- and nicotine-containing products

(2018) Satoru Munakata et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

(2018) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Cholinergic Pathways in Inflammation: A Potential Pharmacotherapeutic Target for COPD

(2018) Mitsuhiro Yamada et al.   Frontiers in Pharmacology

Acetylcholine signaling system in progression of lung cancers

(2018) Jamie R. Friedman et al.   PHARMACOLOGY & THERAPEUTICS

Evaluating Commercially Available Antibodies for Rat α7 Nicotinic Acetylcholine Receptors

(2017) Brijesh K. Garg et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Deficiency of α7 Nicotinic Acetylcholine Receptor Attenuates Bleomycin-Induced Lung Fibrosis in Mice

(2017) Peiyu Sun et al.   MOLECULAR MEDICINE

The α7-nACh nicotinic receptor and its role in memory and selected diseases of the central nervous system

(2017) Urszula Baranowska et al.   Postepy Higieny I Medycyny Doswiadczalnej

Expression patterns for nicotinic acetylcholine receptor subunit genes in smoking-related lung cancers

(2017) Anna Bordas et al.   Oncotarget

Alpha5 Nicotinic Acetylcholine Receptor Contributes to Nicotine-Induced Lung Cancer Development and Progression

(2017) Hai-Ji Sun et al.   Frontiers in Pharmacology

Nicotinic acetylcholine receptor expression in human airway correlates with lung function

(2016) David Chi-Leung Lam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing

(2016) Fani Koukouli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain

(2016) Jie Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

α5-nAChR modulates nicotine-induced cell migration and invasion in A549 lung cancer cells

(2015) Haiji Sun et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Suitability of Nicotinic Acetylcholine Receptor α7 and Muscarinic Acetylcholine Receptor 3 Antibodies for Immune Detection

(2015) Frank R. Rommel et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Role of nicotinic acetylcholine receptors in cell proliferation and tumour invasion in broncho-pulmonary carcinomas

(2015) Kahina Medjber et al.   LUNG CANCER

The nicotinic acetylcholine receptor: From molecular biology to cognition

(2015) Jean-Pierre Changeux et al.   NEUROPHARMACOLOGY

Four SNPs in the CHRNA3/5 Alpha-Neuronal Nicotinic Acetylcholine Receptor Subunit Locus Are Associated with COPD Risk Based on Meta-Analyses

(2014) Kai Cui et al.   PLoS One

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis

(2014) Michael H Cho et al.   Lancet Respiratory Medicine

Are nicotinic acetylcholine receptors coupled to G proteins?

(2013) Nadine Kabbani et al.   BIOESSAYS

British Thoracic Society guideline for diagnostic flexible bronchoscopy in adults: accredited by NICE

(2013) I A Du Rand et al.   THORAX

Nicotinic acetylcholine receptor ligands, a patent review (2006 – 2011)

(2011) Daniela Gündisch et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Loci Identified by Genome-wide Association Studies Influence Different Disease-related Phenotypes in Chronic Obstructive Pulmonary Disease

(2010) Sreekumar G. Pillai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

(2010)   NATURE GENETICS

α7 Nicotinic Acetylcholine Receptor Regulates Airway Epithelium Differentiation by Controlling Basal Cell Proliferation

(2009) Kamel Maouche et al.   AMERICAN JOURNAL OF PATHOLOGY

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci

(2009) Sreekumar G. Pillai et al.   PLoS Genetics

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

(2008) Rayjean J. Hung et al.   NATURE

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

(2008) Christopher I Amos et al.   NATURE GENETICS