The Cholinergic Pathways in Inflammation: A Potential Pharmacotherapeutic Target for COPD

Crosstalk between mAChRM3 and β2AR, via acetylcholine PI3/PKC/PBEP1/Raf-1 MEK1/2/ERK1/2 pathway activation, in human bronchial epithelial cells after long-term cigarette smoke exposure

(2018) Giusy Daniela Albano et al.   LIFE SCIENCES

Glycopyrronium bromide inhibits lung inflammation and small airway remodeling induced by subchronic cigarette smoke exposure in mice

(2018) Yi-Han Hsiao et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Pulmonary neuroendocrine cells amplify allergic asthma responses

(2018) Pengfei Sui et al.   SCIENCE

β2-adrenergic receptor–mediated negative regulation of group 2 innate lymphoid cell responses

(2018) Saya Moriyama et al.   SCIENCE

GTS-21 Reduces Inflammation in Acute Lung Injury by Regulating M1 Polarization and Function of Alveolar Macrophages

(2018) Jing Wang et al.   SHOCK

Tiotropium and olodaterol in the prevention of chronic obstructive pulmonary disease exacerbations (DYNAGITO): a double-blind, randomised, parallel-group, active-controlled trial

(2018) Peter M A Calverley et al.   Lancet Respiratory Medicine

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Early life allergen-induced mucus overproduction requires augmented neural stimulation of pulmonary neuroendocrine cell secretion

(2017) Juliana Barrios et al.   FASEB JOURNAL

Acute lung injury is reduced by the α7nAChR agonist PNU-282987 through changes in the macrophage profile

(2017) Nathalia M. Pinheiro et al.   FASEB JOURNAL

Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution

(2017) Jesmond Dalli et al.   IMMUNITY

Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells

(2017) Linda Quatrini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deficiency of α7 Nicotinic Acetylcholine Receptor Attenuates Bleomycin-Induced Lung Fibrosis in Mice

(2017) Peiyu Sun et al.   MOLECULAR MEDICINE

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

(2017) Antonia Wallrapp et al.   NATURE

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

(2017) Christoph S. N. Klose et al.   NATURE

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

(2017) Vânia Cardoso et al.   NATURE

Alpha7 Nicotine Acetylcholine Receptor Agonist PNU-282987 Attenuates Acute Lung Injury in a Cardiopulmonary Bypass Model in Rats

(2017) Jiaxi Ge et al.   SHOCK

Expression patterns for nicotinic acetylcholine receptor subunit genes in smoking-related lung cancers

(2017) Anna Bordas et al.   Oncotarget

Signals of vagal circuits engaging with AKT1 in α7 nAChR+CD11b+ cells lessen E. coli and LPS-induced acute inflammatory injury

(2017) Caiqi Zhao et al.   Cell Discovery

Nicotinic alpha 7 receptor expression and modulation of the lung epithelial response to lipopolysaccharide

(2017) Lorise C. Gahring et al.   PLoS One

Alpha7 nicotinic acetylcholine receptor activation attenuated intestine-derived acute lung injury

(2016) Ye He et al.   JOURNAL OF SURGICAL RESEARCH

IL-17A induces chromatin remodeling promoting IL-8 release in bronchial epithelial cells: Effect of Tiotropium

(2016) Giulia Anzalone et al.   LIFE SCIENCES

Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence

(2016) Sales Ibiza et al.   NATURE

Effects of Nicotine and Vagus Nerve in Severe Acute Pancreatitis–Associated Lung Injury in Rats

(2016) Peng Ma et al.   PANCREAS

Nicotine-Mediated Regulation of Nicotinic Acetylcholine Receptors in Non-Small Cell Lung Adenocarcinoma by E2F1 and STAT1 Transcription Factors

(2016) Courtney Schaal et al.   PLoS One

Effect of tiotropium on mucus hypersecretion and airway clearance in patients with COPD

(2016) Etsuko Tagaya et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Anti-Inflammatory Effects of β2-Receptor Agonists Salbutamol and Terbutaline Are Mediated by MKP-1

(2016) Tiina Keränen et al.   PLoS One

Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice

(2015) Loes E. M. Kistemaker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors

(2015) Alex I Chernyavsky et al.   BMC CANCER

The long-acting β2-adrenoceptor agonist olodaterol attenuates pulmonary inflammation

(2015) Eva Wex et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-inflammatory effects of targeted lung denervation in patients with COPD

(2015) Loes E.M. Kistemaker et al.   EUROPEAN RESPIRATORY JOURNAL

Tiotropium and olodaterol fixed-dose combinationversusmono-components in COPD (GOLD 2–4)

(2015) Roland Buhl et al.   EUROPEAN RESPIRATORY JOURNAL

Beta-2 Adrenergic Agonists Are Substrates and Inhibitors of Human Organic Cation Transporter 1

(2015) Johanna J. Salomon et al.   MOLECULAR PHARMACEUTICS

Efficacy and safety of long-acting β-agonist/long-acting muscarinic antagonist combinations in COPD: a network meta-analysis

(2015) Yuji Oba et al.   THORAX

Non-neuronal cholinergic airway epithelium biology

(2014) Wolfgang Kummer et al.   CURRENT OPINION IN PHARMACOLOGY

Inhalation of glycopyrronium inhibits cigarette smoke-induced acute lung inflammation in a murine model of COPD

(2014) Liang-liang Shen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effect of QVA149 on lung volumes and exercise tolerance in COPD patients: The BRIGHT study

(2014) Kai-Michael Beeh et al.   RESPIRATORY MEDICINE

Efficacy and safety of coadministration of once-daily indacaterol and glycopyrronium versus indacaterol alone in COPD patients: the GLOW6 study

(2014) Walter Vincken et al.   International Journal of Chronic Obstructive Pulmonary Disease

?7 nAChR in Airway Respiratory Epithelial Cells

(2013)   CURRENT DRUG TARGETS

Dual bronchodilation with QVA149 reduces patient-reported dyspnoea in COPD: the BLAZE study

(2013) D. A. Mahler et al.   EUROPEAN RESPIRATORY JOURNAL

Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice

(2013) Loes E.M. Kistemaker et al.   EUROPEAN RESPIRATORY JOURNAL

Contribution of  7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure

(2013) K. Maouche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tiotropium sustains the anti-inflammatory action of olodaterol via the cyclic AMP pathway

(2013) Luigi Costa et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomised, double-blind, parallel-group study

(2013) Jadwiga A Wedzicha et al.   Lancet Respiratory Medicine

Role of M3 mAChR in in vivo and in vitro models of LPS-induced inflammatory response

(2012) Zu-Peng Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Expression of muscarinic receptors by human macrophages

(2011) A. Koarai et al.   EUROPEAN RESPIRATORY JOURNAL

β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system

(2011) Gergely Vida et al.   FASEB JOURNAL

Cigarette smoke extract activates human bronchial epithelial cells affecting non-neuronal cholinergic system signalling in vitro

(2011) Mirella Profita et al.   LIFE SCIENCES

Effects of formoterol and tiotropium bromide on mucus clearance in patients with COPD

(2011) Thomas Meyer et al.   RESPIRATORY MEDICINE

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

(2011) M. Rosas-Ballina et al.   SCIENCE

Neuroimmune Regulation of Ventilator-induced Lung Injury

(2010) Claudia C. dos Santos et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tiotropium bromide exerts anti-inflammatory activity in a cigarette smoke mouse model of COPD

(2010) L. Wollin et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells

(2009) R. Gosens et al.   EUROPEAN RESPIRATORY JOURNAL

Anti-inflammatory effects of salmeterol/fluticasone, tiotropium/fluticasone or tiotropium in COPD

(2009) D-W. Perng et al.   EUROPEAN RESPIRATORY JOURNAL

Requisite Role of the Cholinergic α7 Nicotinic Acetylcholine Receptor Pathway in Suppressing Gram-Negative Sepsis-Induced Acute Lung Inflammatory Injury

(2009) Xiao Su et al.   JOURNAL OF IMMUNOLOGY

Preclinical Evaluation of Long-Acting Muscarinic Antagonists: Comparison of Tiotropium and Investigational Drugs

(2009) P. Casarosa et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism

(2008) Mirella Profita et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia

(2008) M. Rosas-Ballina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA