Alternative Options for Skin Cancer Therapy via Regulation of AKT and Related Signaling Pathways

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

α‐Mangostin attenuates stemness and enhances cisplatin‐induced cell death in cervical cancer stem‐like cells through induction of mitochondrial‐mediated apoptosis

(2020) Hung‐Ju Chien et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Anticancer activity of dietary xanthone α-mangostin against hepatocellular carcinoma by inhibition of STAT3 signaling via stabilization of SHP1

(2020) Hai Zhang et al.   Cell Death & Disease

Chinese Herbal Medicines for Rheumatoid Arthritis: Text-Mining the Classical Literature for Potentially Effective Natural Products

(2020) Xuan Xia et al.   Evidence-based Complementary and Alternative Medicine

Development and in-vitro evaluation of co-loaded berberine chloride and evodiamine ethosomes for treatment of melanoma

(2020) Hongmei Lin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pristimerin‐induced uveal melanoma cell death via inhibiting PI3K/Akt/FoxO3a signalling pathway

(2020) Fengxia Yan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Isorhamnetin Induces Melanoma Cell Apoptosis via the PI3K/Akt and NF-κB Pathways

(2020) Ran Duan et al.   Biomed Research International

The Role of Nicotinamide in Cancer Chemoprevention and Therapy

(2020) Ilias P. Nikas et al.   Biomolecules

Therapeutic Applications of Curcumin and its Novel Formulations in the Treatment of Bladder Cancer: A Review of Current Evidence

(2020) Mohammad Hossein Pourhanifeh et al.   Anti-Cancer Agents in Medicinal Chemistry

Dietary Phenolics against Breast Cancer. A Critical Evidence-Based Review and Future Perspectives

(2020) María Ángeles Ávila-Gálvez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Syringic acid modulates molecular marker–involved cell proliferation, survival, apoptosis, inflammation, and angiogenesis in DMBA‐induced oral squamous cell carcinoma in Syrian hamsters

(2020) Velu Periyannan et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Antitumor activity of luteolin in human colon cancer SW620 cells is mediated by the ERK/FOXO3a signaling pathway

(2020) Iva Potočnjak et al.   TOXICOLOGY IN VITRO

Polyphyllin I Promoted Melanoma Cells Autophagy and Apoptosis via PI3K/Akt/mTOR Signaling Pathway

(2020) Jianwen Long et al.   Biomed Research International

Silibinin down-regulates PD-L1 expression in nasopharyngeal carcinoma by interfering with tumor cell glycolytic metabolism

(2020) Leïla Sarah Sellam et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Bee Venom and Its Peptide Component Melittin Suppress Growth and Migration of Melanoma Cells via Inhibition of PI3K/AKT/mTOR and MAPK Pathways

(2019) Haet Lim et al.   MOLECULES

AKT as a Therapeutic Target for Cancer

(2019) Mengqiu Song et al.   CANCER RESEARCH

Estimating Health Care Costs of Non-Melanoma Skin Cancer in Saskatchewan using Physician Billing Data

(2019) D. A. Tran et al.   Current Oncology

Fisetin loaded binary ethosomes for management of skin cancer by dermal application on UV exposed mice

(2019) Thasleem Moolakkadath et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The Clinical Trial Landscape for Melanoma Therapies

(2019) Sonia Wróbel et al.   Journal of Clinical Medicine

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017

(2019) et al.   JAMA Oncology

Sinomenine sensitizes human gastric cancer cells to cisplatin through negative regulation of PI3K/AKT/Wnt signaling pathway

(2019) Ying Liu et al.   ANTI-CANCER DRUGS

Targeting AKT for cancer therapy

(2019) Maryam Shariati et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Inhibitory Effects of Pectinase‐Treated Prunus Mume Fruit Concentrate on Colorectal Cancer Proliferation and Angiogenesis of Endothelial Cells

(2019) Hyun‐Dong Cho et al.   JOURNAL OF FOOD SCIENCE

Gambogic acid exhibits anti-metastatic activity on malignant melanoma mainly through inhibition of PI3K/Akt and ERK signaling pathways

(2019) Chun-yu Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Polyphyllin I inhibits gastric cancer cell proliferation by downregulating the expression of fibroblast activation protein alpha (FAP) and hepatocyte growth factor (HGF) in cancer-associated fibroblasts

(2018) Ruizeng Dong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Syringic acid prevents skin carcinogenesis via regulation of NoX and EGFR signaling

(2018) Su Jeong Ha et al.   BIOCHEMICAL PHARMACOLOGY

Molecular Targets of Phytochemicals for Skin Inflammation

(2018) Jong-Eun Kim et al.   CURRENT PHARMACEUTICAL DESIGN

Ginkgo biloba Exocarp Extract Inhibits the Metastasis of B16-F10 Melanoma Involving PI3K/Akt/NF-κB/MMP-9 Signaling Pathway

(2018) Chenjie Cao et al.   Evidence-based Complementary and Alternative Medicine

Anticarcinogenic activities of sulforaphane are influenced by Nerve Growth Factor in human melanoma A375 cells

(2018) Paola Arcidiacono et al.   FOOD AND CHEMICAL TOXICOLOGY

DNA Damage, Mutagenesis and Cancer

(2018) Ashis Basu   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxyfadichalcone C inhibits melanoma A375 cell proliferation and metastasis via suppressing PI3K/Akt and MAPK/ERK pathways

(2018) Xiaolin Peng et al.   LIFE SCIENCES

Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate Euplotes crassus, Against Human Melanoma Cells

(2018) Sara Carpi et al.   Marine Drugs

Targeting AKT with Oridonin Inhibits Growth of Esophageal Squamous Cell CarcinomaIn Vitroand Patient-Derived XenograftsIn Vivo

(2018) Mengqiu Song et al.   MOLECULAR CANCER THERAPEUTICS

Targeting PRPK and TOPK for skin cancer prevention and therapy

(2018) Eunmiri Roh et al.   ONCOGENE

The Anticancer Activity of Sea Buckthorn [Elaeagnus rhamnoides (L.) A. Nelson]

(2018) Beata Olas et al.   Frontiers in Pharmacology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Berberine Inhibits Human Melanoma A375.S2 Cell Migration and Invasion via Affecting the FAK, uPA, and NF-κB Signaling Pathways and Inhibits PLX4032 Resistant A375.S2 Cell Migration In Vitro

(2018) Jia-Fang Liu et al.   MOLECULES

Sinomenine inhibits the growth of melanoma by enhancement of autophagy via PI3K/AKT/mTOR inhibition

(2018) Zheng Sun et al.   Drug Design Development and Therapy

Chrysin inhibit human melanoma A375.S2 cell migration and invasion via affecting MAPK signaling and NF-κB signaling pathway in vitro

(2018) Hsin-Yu Chen et al.   ENVIRONMENTAL TOXICOLOGY

Lycorine inhibits melanoma A375 cell growth and metastasis through the inactivation of the PI3K/AKT signaling pathway

(2018) Qun-Qun Jiang et al.   M S-MEDECINE SCIENCES

Casticin impairs cell migration and invasion of mouse melanoma B16F10 cells via PI3K/AKT and NF-κB signaling pathways

(2017) Yung-Luen Shih et al.   ENVIRONMENTAL TOXICOLOGY

Prognostic significance of cyclooxygenase 2 and phosphorylated Akt1 overexpression in primary nonmetastatic and metastatic cutaneous melanomas

(2017) Ciro D. Soares et al.   MELANOMA RESEARCH

Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells

(2017) Guangming Zhao et al.   ONCOLOGY REPORTS

Silibinin Treatment Inhibits the Growth of Hedgehog Inhibitor-Resistant Basal Cell Carcinoma Cells via Targeting EGFR-MAPK-Akt and Hedgehog Signaling

(2017) Arpit Dheeraj et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3β signaling

(2017) Xiao-Yu Chen et al.   Oncotarget

Polyphyllin I suppresses human osteosarcoma growth by inactivation of Wnt/β-catenin pathway in vitro and in vivo

(2017) Junli Chang et al.   Scientific Reports

Ginkgo biloba exocarp extracts inhibits angiogenesis and its effects on Wnt/β-catenin-VEGF signaling pathway in Lewis lung cancer

(2016) Dongdong Han et al.   JOURNAL OF ETHNOPHARMACOLOGY

Phytochemicals for the Management of Melanoma

(2016) Harish Chandra Pal et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Implications of Genetic and Epigenetic Alterations of CDKN2A (p16 INK4a ) in Cancer

(2016) Ran Zhao et al.   EBioMedicine

Prevalence and Costs of Skin Cancer Treatment in the U.S., 2002−2006 and 2007−2011

(2015) Gery P. Guy et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity

(2015) D. J. Kim et al.   CANCER RESEARCH

Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17

(2015) Mee-Hyun Lee et al.   CARCINOGENESIS

Curcumin induces autophagy, inhibits proliferation and invasion by downregulating AKT/mTOR signaling pathway in human melanoma cells

(2015) GUANGMING ZHAO et al.   ONCOLOGY REPORTS

DW-F5: A novel formulation against malignant melanoma from Wrightia tinctoria

(2015) Jayesh Antony et al.   Scientific Reports

AKT1 Activation Promotes Development of Melanoma Metastases

(2015) Joseph H. Cho et al.   Cell Reports

Silibinin and its 2,3-dehydro-derivative inhibit basal cell carcinoma growth via suppression of mitogenic signaling and transcription factors activation

(2014) Cynthia Tilley et al.   MOLECULAR CARCINOGENESIS

Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth

(2013) M.-H. Lee et al.   Cancer Prevention Research

Isoangustone A, A Novel Licorice Compound, Inhibits Cell Proliferation by Targeting PI3K, MKK4, and MKK7 in Human Melanoma

(2013) N. R. Song et al.   Cancer Prevention Research

The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer

(2013) Sung Keun Jung et al.   CARCINOGENESIS

Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP)-2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway

(2013) XIAOLEI LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Synthesis, anti-tumor activity, and structure–activity relationships of curcumol derivatives

(2013) Ping Guo et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Luteolin Inhibits Protein Kinase C  and c-Src Activities and UVB-Induced Skin Cancer

(2010) S. Byun et al.   CANCER RESEARCH