Anticancer activity of dietary xanthone α-mangostin against hepatocellular carcinoma by inhibition of STAT3 signaling via stabilization of SHP1

Ubiquitination of MAP1LC3B by pVHL is associated with autophagy and cell death in renal cell carcinoma

(2019) Hyun Mi Kang et al.   Cell Death & Disease

The regulatory protein GADD34 inhibits TRAIL-induced apoptosis via TRAF6/ERK-dependent stabilization of myeloid cell leukemia 1 in liver cancer cells

(2019) Peiying Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay between primary cilia, ubiquitin-proteasome system and autophagy

(2019) Asma Boukhalfa et al.   BIOCHIMIE

A new xanthatin analogue 1 β -hydroxyl-5 α -chloro-8-epi-xanthatin induces apoptosis through ROS-mediated ERK/p38 MAPK activation and JAK2/STAT3 inhibition in human hepatocellular carcinoma

(2018) Xin-Yi Fang et al.   BIOCHIMIE

Bioactivity and pharmacological properties of α-mangostin from the mangosteen fruit: a review

(2018) Guoqing Chen et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Structural Biology of STAT3 and Its Implications for Anticancer Therapies Development

(2018) Jacopo Sgrignani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

RING finger protein 38 induces gastric cancer cell growth by decreasing the stability of the protein tyrosine phosphatase SHP-1

(2018) Jigang Zhang et al.   FEBS LETTERS

Pseudolaric acid B exhibits anti-cancer activity on human hepatocellular carcinoma through inhibition of multiple carcinogenic signaling pathways

(2018) Hai Zhang et al.   PHYTOMEDICINE

Alpha-mangostin: Anti-inflammatory and antioxidant effects on established collagen-induced arthritis in DBA/1J mice

(2018) Diana Rocio Herrera-Aco et al.   FOOD AND CHEMICAL TOXICOLOGY

α-Mangostin ameliorates dextran sulfate sodium-induced colitis through inhibition of NF-κB and MAPK pathways

(2017) Byoung Hoon You et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ubiquitin signaling and autophagy

(2017) Paolo Grumati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

Recent advances in hepatocellular carcinoma therapy

(2017) Rinku Dutta et al.   PHARMACOLOGY & THERAPEUTICS

Dietary quercetin potentiates the antiproliferative effect of interferon-α in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase

(2017) Ighodaro Igbe et al.   Oncotarget

Epidemiology of hepatocellular carcinoma: target population for surveillance and diagnosis

(2017) An Tang et al.   Abdominal Radiology

Strategies and Approaches of Targeting STAT3 for Cancer Treatment

(2016) Steffanie L. Furtek et al.   ACS Chemical Biology

Cancer statistics in China, 2015

(2016) Wanqing Chen et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Feedback Activation of STAT3 as a Cancer Drug-Resistance Mechanism

(2016) Chengguang Zhao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Dietary Natural Products for Prevention and Treatment of Liver Cancer

(2016) Yue Zhou et al.   Nutrients

The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression

(2016) Jiandong Chen   Cold Spring Harbor Perspectives in Medicine

STAT3 the oncogene - still eluding therapy?

(2015) Matthew S. Wake et al.   FEBS Journal

SHP-1 is a negative regulator of epithelial–mesenchymal transition in hepatocellular carcinoma

(2015) L-C Fan et al.   ONCOGENE

Phase I Study of OPB-31121, an Oral STAT3 Inhibitor, in Patients with Advanced Solid Tumors

(2015) Do-Youn Oh et al.   Cancer Research and Treatment

α-Mangostin suppresses human gastric adenocarcinoma cells in vitro via blockade of Stat3 signaling pathway

(2014) Tao Shan et al.   ACTA PHARMACOLOGICA SINICA

α-Mangostin induces mitochondrial dependent apoptosis in human hepatoma SK-Hep-1 cells through inhibition of p38 MAPK pathway

(2013) Shu-Ching Hsieh et al.   APOPTOSIS

Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3

(2013) Aruljothi Subramaniam et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation

(2013) X. Zhang et al.   CANCER RESEARCH

Discovery of novel src homology region 2 domain-containing phosphatase 1 agonists from sorafenib for the treatment of hepatocellular carcinoma

(2013) Wei-Tien Tai et al.   HEPATOLOGY

Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells

(2012) Jie Yang et al.   CANCER LETTERS

Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trial

(2012) Jordi Bruix et al.   JOURNAL OF HEPATOLOGY

Anti-angiogenic effect of α-mangostin

(2012) Tomoko Shiozaki et al.   Journal of Natural Medicines

NF-κB and STAT3 – key players in liver inflammation and cancer

(2010) Guobin He et al.   CELL RESEARCH

Activation of STAT3 Signal Pathway Correlates with Twist and E-Cadherin Expression in Hepatocellular Carcinoma and Their Clinical Significance

(2010) Chuan-Hai Zhang et al.   JOURNAL OF SURGICAL RESEARCH

α-Mangostin Suppresses PC-3 Human Prostate Carcinoma Cell Metastasis by Inhibiting Matrix Metalloproteinase-2/9 and Urokinase-Plasminogen Expression through the JNK Signaling Pathway

(2009) Shun-Hsing Hung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Signal Transducer and Activator of Transcription 3 (STAT3) Mediates Amino Acid Inhibition of Insulin Signaling through Serine 727 Phosphorylation

(2009) Jeong-Ho Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein tyrosine phosphatases in the JAK/STAT pathway

(2008) Dan Xu   Frontiers in Bioscience-Landmark