Hedgehog Signaling in Skeletal Development: Roles of Indian Hedgehog and the Mode of Its Action

Indian hedgehog in craniofacial neural crest cells links to skeletal malocclusion by regulating associated cartilage formation and gene expression

(2020) Katsuhiko Amano et al.   FASEB JOURNAL

Hedgehog Inhibitors Suppress Osteoclastogenesis in In Vitro Cultures, and Deletion of Smo in Macrophage/Osteoclast Lineage Prevents Age-Related Bone Loss

(2020) Yukihiro Kohara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hedgehog Activation Regulates Human Osteoblastogenesis

(2020) Shoko Onodera et al.   Stem Cell Reports

Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate

(2019) Haraguchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fox proteins are modular competency factors for facial cartilage and tooth specification

(2018) Pengfei Xu et al.   DEVELOPMENT

Growth plate-derived hedgehog-signal-responsive cells provide skeletal tissue components in growing bone

(2018) Ryuma Haraguchi et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Identification of the Human Skeletal Stem Cell

(2018) Charles K.F. Chan et al.   CELL

Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration

(2018) Ryan C. Ransom et al.   NATURE

Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog)

(2017) Anja J Will et al.   NATURE GENETICS

Gli1 identifies osteogenic progenitors for bone formation and fracture repair

(2017) Yu Shi et al.   Nature Communications

Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling

(2016) Hongchen Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and Specification of the Mouse Skeletal Stem Cell

(2015) Charles K.F. Chan et al.   CELL

Reduced cholesterol levels impair Smoothened activation in Smith–Lemli–Opitz syndrome

(2015) Robert Blassberg et al.   HUMAN MOLECULAR GENETICS

Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation

(2015) Katsuhiko Amano et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Gli1 Haploinsufficiency Leads to Decreased Bone Mass with an Uncoupling of Bone Metabolism in Adult Mice

(2014) Yoshiaki Kitaura et al.   PLoS One

Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice

(2014) Jingming Zhou et al.   ARTHRITIS RESEARCH & THERAPY

Hedgehog-Gli Activators Direct Osteo-chondrogenic Function of Bone Morphogenetic Protein toward Osteogenesis in the Perichondrium

(2013) Hironori Hojo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification

(2013) Jean B Regard et al.   NATURE MEDICINE

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A review of hedgehog signaling in cranial bone development

(2013) Angel Pan et al.   Frontiers in Physiology

Neural crest induction at the neural plate border in vertebrates

(2012) Cécile Milet et al.   DEVELOPMENTAL BIOLOGY

Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies

(2012) Alyson Ashe et al.   HUMAN MOLECULAR GENETICS

Gli1 Protein Participates in Hedgehog-mediated Specification of Osteoblast Lineage during Endochondral Ossification

(2012) Hironori Hojo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage

(2012) F. Wei et al.   OSTEOARTHRITIS AND CARTILAGE

Indian hedgehog requires additional effectors besides Runx2 to induce osteoblast differentiation

(2011) Xiaolin Tu et al.   DEVELOPMENTAL BIOLOGY

Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling

(2011) Kelly Lenton et al.   GENESIS

Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors

(2010) C. Wang et al.   DEVELOPMENT

A primary cilia-dependent etiology for midline facial disorders

(2010) Samantha A. Brugmann et al.   HUMAN MOLECULAR GENETICS

Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life

(2010) T. Hirai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor

(2009) Yukiko Maeda et al.   BONE

The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization

(2009) K. S. Joeng et al.   DEVELOPMENT

A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range

(2009) Bo Gao et al.   NATURE

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy

(2008) K. K. Mak et al.   DEVELOPMENT

Patched1 Haploinsufficiency Increases Adult Bone Mass and Modulates Gli3 Repressor Activity

(2008) Shinsuke Ohba et al.   DEVELOPMENTAL CELL

Hedgehog Signaling in Mature Osteoblasts Regulates Bone Formation and Resorption by Controlling PTHrP and RANKL Expression

(2008) Kinglun Kingston Mak et al.   DEVELOPMENTAL CELL

Genome-wide association analysis identifies 20 loci that influence adult height

(2008) Michael N Weedon et al.   NATURE GENETICS

Identification of ten loci associated with height highlights new biological pathways in human growth

(2008) Guillaume Lettre et al.   NATURE GENETICS