History of Nonalcoholic Fatty Liver Disease

Epidemiology of Non-alcoholic Fatty Liver Disease in North America

(2020) Tamoore Arshad et al.   CURRENT PHARMACEUTICAL DESIGN

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

(2020) Mohammed Eslam et al.   GASTROENTEROLOGY

Nonalcoholic Fatty Liver Disease in Children: Unique Considerations and Challenges

(2020) Dana Goldner et al.   GASTROENTEROLOGY

Nonalcoholic Steatohepatitis

(2020) Adam C. Sheka et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

(2020) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

What's in a name? Renaming ‘NAFLD’ to ‘MAFLD’

(2020) Yasser Fouad et al.   LIVER INTERNATIONAL

Extracellular Vesicles in NAFLD/ALD: From Pathobiology to Therapy

(2020) Alejandra Hernández et al.   Cells

From NAFLD to MAFLD: Implications of a premature change in terminology

(2020) Zobair M Younossi et al.   HEPATOLOGY

Suboptimal reliability of liver biopsy evaluation has implications for randomized clinical trials

(2020) Beth A. Davison et al.   JOURNAL OF HEPATOLOGY

Comparison of MAFLD and NAFLD diagnostic criteria in real world

(2020) Su Lin et al.   LIVER INTERNATIONAL

The Epigenetic Drug Discovery Landscape for Metabolic-associated Fatty Liver Disease

(2020) Ali Bayoumi et al.   TRENDS IN GENETICS

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Liver fibrosis is associated with risk for colorectal adenoma in patients with nonalcoholic fatty liver disease

(2019) Min Cheol Kim et al.   MEDICINE

Unexpected Rapid Increase in the Burden of Nonalcoholic Fatty Liver Disease in China From 2008 to 2018: A Systematic Review and Meta‐Analysis

(2019) Feng Zhou et al.   HEPATOLOGY

Past, present and future perspectives in nonalcoholic fatty liver disease

(2019) Arun J. Sanyal   Nature Reviews Gastroenterology & Hepatology

Are Nonalcoholic Fatty Liver Disease and Alcoholic Fatty Liver Disease More Than Just Semantics?

(2019) Mohammed Eslam et al.   GASTROENTEROLOGY

Position statement on the diagnosis and management of non-alcoholic fatty liver disease

(2019) Khalid Alswat et al.   SAUDI MEDICAL JOURNAL

Genetic Insights for Drug Development in NAFLD

(2019) Mohammed Eslam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Extra-hepatic manifestations and complications of nonalcoholic fatty liver disease

(2019) Stefano Ballestri et al.   Future Medicinal Chemistry

The Risk of Incident Extrahepatic Cancers is higher in Nonalcoholic Fatty Liver Disease than Obesity - a Longitudinal Cohort Study

(2019) Alina M. Allen et al.   JOURNAL OF HEPATOLOGY

Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology

(2019) Mohammed Eslam et al.   Nature Reviews Gastroenterology & Hepatology

Obeticholic acid: towards first approval for NASH

(2019) Mohammed Eslam et al.   LANCET

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

(2019) Zobair M Younossi et al.   LANCET

Nonalcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: A Meta-analysis

(2018) Alessandro Mantovani et al.   DIABETES CARE

From a fatty liver to a sugary blood

(2018) Amedeo Lonardo et al.   DIGESTIVE AND LIVER DISEASE

Should we undertake surveillance for HCC in patients with NAFLD?

(2018) Ramy Younes et al.   JOURNAL OF HEPATOLOGY

Genetics and epigenetics of NAFLD and NASH: Clinical impact

(2018) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Burden of liver disease in Europe: Epidemiology and analysis of risk factors to identify prevention policies

(2018) Laura Pimpin et al.   JOURNAL OF HEPATOLOGY

Is cryptogenic cirrhosis different from NASH cirrhosis?

(2018) Paul J. Thuluvath et al.   JOURNAL OF HEPATOLOGY

Cryptogenic vs. NASH-cirrhosis: The rose exists well before its name....

(2018) Stephen Caldwell et al.   JOURNAL OF HEPATOLOGY

Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence?

(2018) Amedeo Lonardo et al.   JOURNAL OF HEPATOLOGY

Association between nonalcoholic fatty liver disease and colorectal tumours in asymptomatic adults undergoing screening colonoscopy: a systematic review and meta-analysis

(2018) Alessandro Mantovani et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease

(2018) Noura S. Abul-Husn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systematic review with meta-analysis: risk of hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis compared to other liver diseases

(2018) Jonathan G. Stine et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Current guidelines for the management of non-alcoholic fatty liver disease: A systematic review with comparative analysis

(2018) Simona Leoni et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma

(2018) Ozlem Kutlu et al.   Canadian Journal of Gastroenterology and Hepatology

Propensity for Intra-abdominal and Hepatic Adiposity Varies Among Ethnic Groups

(2018) Unhee Lim et al.   GASTROENTEROLOGY

A polymorphism in the Irisin-encoding gene (FNDC5) associates with hepatic steatosis by differential miRNA binding to the 3′UTR

(2018) Mayada Metwally et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic fatty liver disease – A global public health perspective

(2018) Zobair M. Younossi   JOURNAL OF HEPATOLOGY

The membrane-bound O-acyltransferase domain-containing 7 variant rs641738 increases inflammation and fibrosis in chronic hepatitis B

(2017) Khaled Thabet et al.   HEPATOLOGY

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

The Asia-Pacific Working Party on Non-alcoholic Fatty Liver Disease guidelines 2017-Part 2: Management and special groups

(2017) Shiv Chitturi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Asia-Pacific Working Party on Non-alcoholic Fatty Liver Disease guidelines 2017-Part 1: Definition, risk factors and assessment

(2017) Vincent Wai-Sun Wong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Bi-directional analysis between fatty liver and cardiovascular disease risk factors

(2017) Jiantao Ma et al.   JOURNAL OF HEPATOLOGY

NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children

(2017) Miriam B. Vos et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

IFN-λ3, not IFN-λ4, likely mediates IFNL3–IFNL4 haplotype–dependent hepatic inflammation and fibrosis

(2017) Mohammed Eslam et al.   NATURE GENETICS

Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes

(2016) Mohammed Eslam et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Non-Alcoholic Fatty Liver Disease and Extra-Hepatic Cancers

(2016) Claudia Sanna et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis

(2016) Stefano Ballestri et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

FibroGENE: A gene-based model for staging liver fibrosis

(2016) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016)   JOURNAL OF HEPATOLOGY

Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: A meta-analysis

(2016) Giovanni Targher et al.   JOURNAL OF HEPATOLOGY

Nonalcoholic fatty liver disease and hepatocellular carcinoma

(2016) Heinz Zoller et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Clinical guidelines of non-alcoholic fatty liver disease: A systematic review

(2016) Jin-Zhou Zhu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C

(2016) Khaled Thabet et al.   Nature Communications

Visceral adiposity syndrome

(2016) Heno F. Lopes et al.   Diabetology & Metabolic Syndrome

Nonalcoholic fatty liver disease: A precursor of the metabolic syndrome

(2015) Amedeo Lonardo et al.   DIGESTIVE AND LIVER DISEASE

Genetic and epigenetic mechanisms of NASH

(2015) Mohammed Eslam et al.   Hepatology International

Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2015) Sumio Watanabe et al.   JOURNAL OF GASTROENTEROLOGY

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis

(2015) Stephan Buch et al.   NATURE GENETICS

Genome-Wide Association Studies and Hepatitis C: Harvesting the Benefits of the Genomic Revolution

(2015) Mohammed Eslam et al.   SEMINARS IN LIVER DISEASE

Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

(2015) Mohammed Eslam et al.   Nature Communications

Identification of reciprocal causality between non-alcoholic fatty liver disease and metabolic syndrome by a simplified Bayesian network in a Chinese population

(2015) Yongyuan Zhang et al.   BMJ Open

Ceramide as a Mediator of Non-Alcoholic Fatty Liver Disease and Associated Atherosclerosis

(2015) Takhar Kasumov et al.   PLoS One

The Prevalence of Non-Alcoholic Fatty Liver Disease in Children and Adolescents: A Systematic Review and Meta-Analysis

(2015) Emma L. Anderson et al.   PLoS One

Utility and appropriateness of the fatty liver inhibition of progression (FLIP) algorithm and steatosis, activity, and fibrosis (SAF) score in the evaluation of biopsies of nonalcoholic fatty liver disease

(2014) Pierre Bedossa et al.   HEPATOLOGY

World Gastroenterology Organisation Global Guidelines

(2014) Douglas R. LaBrecque et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

(2014) Hannele Yki-Järvinen   Lancet Diabetes & Endocrinology

Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome

(2013) Derrick M. Van Rooyen et al.   JOURNAL OF HEPATOLOGY

From NAFLD in clinical practice to answers from guidelines

(2013) Fabio Nascimbeni et al.   JOURNAL OF HEPATOLOGY

NAFLD in Asia—as common and important as in the West

(2013) Geoffrey C. Farrell et al.   Nature Reviews Gastroenterology & Hepatology

Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease

(2012) Carlos Jose Pirola et al.   GUT

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Development and validation of a new histological score for pediatric non-alcoholic fatty liver disease

(2012) Naim Alkhouri et al.   JOURNAL OF HEPATOLOGY

Identification of individuals with non-alcoholic fatty liver disease by the diagnostic criteria for the metabolic syndrome

(2012) Masahide Hamaguchi   WORLD JOURNAL OF GASTROENTEROLOGY

Changes in the Prevalence of the Most Common Causes of Chronic Liver Diseases in the United States From 1988 to 2008

(2011) Zobair M. Younossi et al.   Clinical Gastroenterology and Hepatology

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

Hepatic Lipid Peroxidation and Cytochrome P-450 2E1 in Pediatric Nonalcoholic Fatty Liver Disease and Its Subtypes

(2011) Lauren N. Bell et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

SREBP-2: A link between insulin resistance, hepatic cholesterol, and inflammation in NASH

(2011) Derrick M Van Rooyen et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

“The city of Hepar”: Rituals, gastronomy, and politics at the origins of the modern names for the liver

(2011) Michele Augusto Riva et al.   JOURNAL OF HEPATOLOGY

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of microRNAs in Non-Alcoholic Steatohepatitis

(2010) Onpan Cheung et al.   CURRENT PHARMACEUTICAL DESIGN

From the metabolic syndrome to NAFLD or vice versa?

(2010) Ester Vanni et al.   DIGESTIVE AND LIVER DISEASE

Practice guidelines for the diagnosis and management of nonalcoholic fatty liver disease

(2010) P. Loria et al.   DIGESTIVE AND LIVER DISEASE

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Guidelines for the diagnosis and management of nonalcoholic fatty liver disease: Update 2010

(2010) Jian Gao FAN et al.   Journal of Digestive Diseases

A position statement on NAFLD/NASH based on the EASL 2009 special conference

(2010) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

Atherosclerosis and diet in ancient Egypt

(2010) A Rosalie David et al.   LANCET

A long look at obesity

(2010) David Haslam et al.   LANCET

Harmonizing the Metabolic Syndrome

(2009) K.G.M.M. Alberti et al.   CIRCULATION

The metabolic syndrome: useful concept or clinical tool? Report of a WHO Expert Consultation

(2009) R. K. Simmons et al.   DIABETOLOGIA

Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease

(2009) Wing–Kin Syn et al.   GASTROENTEROLOGY

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

Intramitochondrial crystalline inclusions in nonalcoholic steatohepatitis

(2009) Stephen H. Caldwell et al.   HEPATOLOGY

What's in a NAme?

(2009) Elizabeth M. Brunt   HEPATOLOGY

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression

(2009) Geoffrey C Farrell et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Kupffer cells in non-alcoholic fatty liver disease: The emerging view

(2009) György Baffy   JOURNAL OF HEPATOLOGY

Role of nonalcoholic fatty liver disease in the development of insulin resistance and diabetes

(2009) Henning Grønbæk et al.   Expert Review of Gastroenterology & Hepatology

The role of fatty acids in the development and progression of nonalcoholic fatty liver disease

(2008) Christopher L. Gentile et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease

(2008) Harmeet Malhi et al.   SEMINARS IN LIVER DISEASE

Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease

(2008) Eric R Kallwitz et al.   WORLD JOURNAL OF GASTROENTEROLOGY

GRADE: an emerging consensus on rating quality of evidence and strength of recommendations

(2008) Gordon H Guyatt et al.   BMJ-British Medical Journal

Impact of Fatty Liver Disease on Health Care Utilization and Costs in a General Population: A 5-Year Observation

(2007) Sebastian E. Baumeister et al.   GASTROENTEROLOGY

Nonalcoholic Fatty Liver Disease: Pathogenesis and Potential for Nuclear Receptors as Therapeutic Targets

(2007) Jacob George et al.   MOLECULAR PHARMACEUTICS