Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging

RESVERATROL DIFFERENTLY MODULATES GROUP I METABOTROPIC GLUTAMATE RECEPTORS DEPENDING ON AGE IN SAMP8 MICE

(2020) Alejandro Sánchez-Melgar et al.   ACS Chemical Neuroscience

SAMP8 Mice as a Model of Age-Related Cognition Decline with Underlying Mechanisms in Alzheimer’s Disease

(2020) Bo Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer’s model mice

(2020) Helena R. Zimmermann et al.   JOURNAL OF CLINICAL INVESTIGATION

Reduced uptake of [11C]‐ABP688, a PET tracer for metabolic glutamate receptor 5 in hippocampus and amygdala in Alzheimer’s dementia

(2020) Valerie Treyer et al.   Brain and Behavior

Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer’s Disease

(2020) Rafael Franco et al.   Cells

Astrocyte Senescence and Alzheimer’s Disease: A Review

(2020) Xiaojuan Han et al.   Frontiers in Aging Neuroscience

Age‐related AMP‐activated protein kinase alterations: From cellular energetics to longevity

(2019) Galina V. Morgunova et al.   CELL BIOCHEMISTRY AND FUNCTION

Gi/o-Protein Coupled Receptors in the Aging Brain

(2019) Patrícia G. de Oliveira et al.   Frontiers in Aging Neuroscience

Adenosine receptors in modulation of central nervous system disorders

(2019) Hira Choudhury et al.   CURRENT PHARMACEUTICAL DESIGN

Complex regulation of ecto-5′-nucleotidase/CD73 and A2AR-mediated adenosine signaling at neurovascular unit: A link between acute and chronic neuroinflammation

(2019) Nadezda Nedeljkovic   PHARMACOLOGICAL RESEARCH

Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis

(2019) Gopakumar Changarathil et al.   PLoS One

Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration

(2019) Rodrigo A Cunha   BRAIN

Adenosine Metabolism: Emerging Concepts for Cancer Therapy

(2019) Detlev Boison et al.   CANCER CELL

Purine-related metabolites and their converting enzymes are altered in frontal, parietal and temporal cortex at early stages of Alzheimer's disease pathology

(2018) Patricia Alonso-Andrés et al.   BRAIN PATHOLOGY

Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain

(2018) Michy P. Kelly   CELLULAR SIGNALLING

Functional Cross-Talk between Adenosine and Metabotropic Glutamate Receptors

(2018) David Agustin Leon-Navarro et al.   Current Neuropharmacology

Caloric restriction can improve learning and memory in C57/BL mice probably via regulation of the AMPK signaling pathway

(2018) Lina Ma et al.   EXPERIMENTAL GERONTOLOGY

Understanding Epigenetics in the Neurodegeneration of Alzheimer’s Disease: SAMP8 Mouse Model

(2018) Christian Griñán-Ferré et al.   JOURNAL OF ALZHEIMERS DISEASE

Association between age‑related hearing loss and cognitive decline in C57BL/6J mice

(2018) Yang Dong et al.   Molecular Medicine Reports

Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors

(2018) Mariana Temido-Ferreira et al.   MOLECULAR PSYCHIATRY

Homeostatic Disinhibition in the Aging Brain and Alzheimer's Disease

(2018) Marc Gleichmann et al.   JOURNAL OF ALZHEIMERS DISEASE

Caffeine Consumption Prevents Memory Impairment, Neuronal Damage, and Adenosine A2A Receptors Upregulation in the Hippocampus of a Rat Model of Sporadic Dementia

(2018) Janaína Espinosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Resveratrol Modulates and Reverses the Age-Related Effect on Adenosine-Mediated Signalling in SAMP8 Mice

(2018) A. Sánchez-Melgar et al.   MOLECULAR NEUROBIOLOGY

Alteration in NMDA Receptor Mediated Glutamatergic Neurotransmission in the Hippocampus During Senescence

(2018) Ashok Kumar et al.   NEUROCHEMICAL RESEARCH

Diet-induced insulin resistance elevates hippocampal glutamate as well as VGLUT1 and GFAP expression in AβPP/PS1 mice

(2018) Erin R. Hascup et al.   JOURNAL OF NEUROCHEMISTRY

Brain Glucose Metabolism: Integration of Energetics with Function

(2018) Gerald A. Dienel   PHYSIOLOGICAL REVIEWS

An alternative model for studying age-associated metabolic complications: Senescence-accelerated mouse prone 8

(2017) Hung-Wen Liu et al.   EXPERIMENTAL GERONTOLOGY

AMPK activation: Role in the signaling pathways of neuroinflammation and neurodegeneration

(2017) Christina Alves Peixoto et al.   EXPERIMENTAL NEUROLOGY

Beneficial effects of dietary restriction in aging brain

(2017) Ibanylla Kynjai Hynniewta Hadem et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer’s disease

(2017) Oriol Busquets et al.   MECHANISMS OF AGEING AND DEVELOPMENT

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions

(2017) Ichiro Akiguchi et al.   NEUROPATHOLOGY

From Aging to Alzheimer's Disease: Unveiling “The Switch” with the Senescence-Accelerated Mouse Model (SAMP8)

(2017) Merce Pallas et al.   JOURNAL OF ALZHEIMERS DISEASE

Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain

(2016) Takamasa Ishii et al.   AGING CELL

Concentration- and age-dependent effects of chronic caffeine on contextual fear conditioning in C57BL/6J mice

(2016) Rachel L. Poole et al.   BEHAVIOURAL BRAIN RESEARCH

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

How does adenosine control neuronal dysfunction and neurodegeneration?

(2016) Rodrigo A. Cunha   JOURNAL OF NEUROCHEMISTRY

Men and mice: Relating their ages

(2016) Sulagna Dutta et al.   LIFE SCIENCES

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

(2016) Pierpaola Davalli et al.   Oxidative Medicine and Cellular Longevity

Deletion of Adenosine A2A Receptors From Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia

(2015) Marco Matos et al.   BIOLOGICAL PSYCHIATRY

Hyperthermia-induced seizures alter adenosine A1and A2Areceptors and 5′-nucleotidase activity in rat cerebral cortex

(2015) David Agustín León-Navarro et al.   JOURNAL OF NEUROCHEMISTRY

AMPK-mediated regulation of neuronal metabolism and function in brain diseases

(2015) Yu-Ju Liu et al.   JOURNAL OF NEUROGENETICS

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

(2015) P Li et al.   MOLECULAR PSYCHIATRY

Purinergic signalling during development and ageing

(2015) Geoffrey Burnstock et al.   Purinergic Signalling

Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells

(2014) Darius Kang Lie Aw et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced striatal adenosine A2A receptor levels define a molecular subgroup in schizophrenia

(2014) Izaskun Villar-Menéndez et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Moonlighting Adenosine Deaminase: A Target Protein for Drug Development

(2014) Antoni Cortés et al.   MEDICINAL RESEARCH REVIEWS

What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus

(2014) Anders M. Fjell et al.   PROGRESS IN NEUROBIOLOGY

Ecto-5'-Nucleotidase (CD73)-Mediated Formation of Adenosine Is Critical for the Striatal Adenosine A2A Receptor Functions

(2013) E. Augusto et al.   JOURNAL OF NEUROSCIENCE

Age-related alteration in cerebral blood flow and energy failure is correlated with cognitive impairment in the senescence-accelerated prone mouse strain 8 (SAMP8)

(2013) Xuezhu Zhang et al.   NEUROLOGICAL SCIENCES

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

The SAMP8 Mouse: A Model to Develop Therapeutic Interventions for Alzheimers Disease

(2012) John E. Morley et al.   CURRENT PHARMACEUTICAL DESIGN

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

Age-related changes in AMP-activated protein kinase after stroke

(2011) Fudong Liu et al.   AGE

The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer's disease

(2011) John E. Morley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Adenosine and ATP Receptors in the Brain

(2011) Geoffrey Burnstock et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Expression of VGLUTs contributes to degeneration and acquisition of learning and memory

(2011) Xiao-Rui Cheng et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

(2010) Valérie Vingtdeux et al.   ACTA NEUROPATHOLOGICA

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

(2009) Rong Yuan et al.   AGING CELL

Comparative Evaluation of Adenosine Deaminase Activity in Cerebral Cortex and Hippocampus of Young and Adult Rats: Effect of Garlic Extract (Allium sativumL.) on Their Susceptibility to Heavy Metal Exposure

(2009) Luziane Potrich Bellé et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Gender- and age-dependent changes in nucleoside levels in the cerebral cortex and white matter of the human brain

(2009) Zsolt Kovács et al.   BRAIN RESEARCH BULLETIN

Age-related expression of adenosine receptors in brain from the senescence-accelerated mouse

(2009) C.A. Castillo et al.   EXPERIMENTAL GERONTOLOGY

Dysfunction of astrocytes in senescence-accelerated mice SAMP8 reduces their neuroprotective capacity

(2008) Silvia García-Matas et al.   AGING CELL

RESEARCH ARTICLE: Up-regulation of Adenosine Receptors in the Frontal Cortex in Alzheimer's Disease

(2008) José L. Albasanz et al.   BRAIN PATHOLOGY

Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses

(2008) Nelson Rebola et al.   NEURON