A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke

The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives

(2020) Alexandra Lucaciu et al.   Cells

Post-Stroke Microglia Induce Sirtuin2 Expression to Suppress the Anti-inflammatory Function of Infiltrating Regulatory T Cells

(2019) Long Shu et al.   INFLAMMATION

Sphingolipidomics Investigation of the Temporal Dynamics after Ischemic Brain Injury

(2019) Hsi-Chun Chao et al.   JOURNAL OF PROTEOME RESEARCH

Role of the S1P pathway and inhibition by fingolimod in preventing hemorrhagic transformation after stroke

(2019) Angélica Salas-Perdomo et al.   Scientific Reports

Sphingosine 1-phosphate: Lipid signaling in pathology and therapy

(2019) Andreane Cartier et al.   SCIENCE

S1P2 contributes to microglial activation and M1 polarization following cerebral ischemia through ERK1/2 and JNK

(2019) Arjun Sapkota et al.   Scientific Reports

Ischaemic stroke

(2019) Bruce C. V. Campbell et al.   Nature Reviews Disease Primers

The emerging alliance of sphingosine-1-phosphate signalling and immune cells: from basic mechanisms to implications in hypertension

(2018) Nicholas Don-Doncow et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors

(2018) Pakawat Chongsathidkiet et al.   NATURE MEDICINE

Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow

(2018) De-Cai Tian et al.   ANNALS OF NEUROLOGY

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

Human Naive and Memory T Cells Display Opposite Migratory Responses to Sphingosine-1 Phosphate

(2017) Annabelle Drouillard et al.   JOURNAL OF IMMUNOLOGY

Sphk1 mediates neuroinflammation and neuronal injury via TRAF2/NF-κB pathways in activated microglia in cerebral ischemia reperfusion

(2017) Danying Su et al.   JOURNAL OF NEUROIMMUNOLOGY

Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes

(2017) Stephanie S. Dusaban et al.   Journal of Neuroinflammation

S1P1 deletion differentially affects TH17 and Regulatory T cells

(2017) Ahmet Eken et al.   Scientific Reports

Fingolimod (FTY720) improves hippocampal synaptic plasticity and memory deficit in rats following focal cerebral ischemia

(2016) Maryam Nazari et al.   BRAIN RESEARCH BULLETIN

Acute Stroke Intervention

(2015) Shyam Prabhakaran et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Exit Strategies: S1P Signaling and T Cell Migration

(2015) Audrey Baeyens et al.   TRENDS IN IMMUNOLOGY

Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin

(2015) Claudia Nussbaum et al.   Nature Communications

Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke

(2015) Gab Seok Kim et al.   Nature Communications

Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond

(2014) Christopher S. Garris et al.   IMMUNOLOGY

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Ischemic neurons recruit natural killer cells that accelerate brain infarction

(2014) Y. Gan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation

(2013) G. Zhang et al.   BLOOD

FTY720 Treatment in the Convalescence Period Improves Functional Recovery and Reduces Reactive Astrogliosis in Photothrombotic Stroke

(2013) Robert Brunkhorst et al.   PLoS One

Role of the Sphingosine Metabolism Pathway on Neurons Against Experimental Cerebral Ischemia in Rats

(2013) Yu Hasegawa et al.   Translational Stroke Research

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

Postischemic Brain Infiltration of Leukocyte Subpopulations Differs among Murine Permanent and Transient Focal Cerebral Ischemia Models

(2012) Wei Zhou et al.   BRAIN PATHOLOGY

New perspectives on central and peripheral immune responses to acute traumatic brain injury

(2012) Mahasweta Das et al.   Journal of Neuroinflammation

Inflammatory Mediators Alter the Astrocyte Transcriptome and Calcium Signaling Elicited by Multiple G-Protein-Coupled Receptors

(2012) M. E. Hamby et al.   JOURNAL OF NEUROSCIENCE

Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia

(2011) Waltraud Pfeilschifter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Lipids and Cholesterol as Regulators of Traffic in the Endomembrane System

(2010) Jennifer Lippincott-Schwartz et al.   Annual Review of Biophysics

Sphingosine-1-Phosphate Receptor 3 Promotes Recruitment of Monocyte/Macrophages in Inflammation and Atherosclerosis

(2010) Petra Keul et al.   CIRCULATION RESEARCH

Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions

(2010) Ruben Van Doorn et al.   GLIA

International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid Receptor Nomenclature

(2010) J. Chun et al.   PHARMACOLOGICAL REVIEWS

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia

(2009) Bozena Czech et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats

(2009) Yu Hasegawa et al.   STROKE

Induction of Membrane Ceramides: A Novel Strategy to Interfere with T Lymphocyte Cytoskeletal Reorganisation in Viral Immunosuppression

(2009) Evelyn Gassert et al.   PLoS Pathogens

FTY720 Rescue Therapy in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis: Expression of Central Nervous System Genes and Reversal of Blood-Brain-Barrier Damage

(2008) Carolyn A. Foster et al.   BRAIN PATHOLOGY

Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate

(2008) Krishnan Venkataraman et al.   CIRCULATION RESEARCH

Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease

(2008) Yun-Ping Wu et al.   HUMAN MOLECULAR GENETICS

S1P1 Receptor Signaling Overrides Retention Mediated by Gαi-Coupled Receptors to Promote T Cell Egress

(2008) Trung H.M. Pham et al.   IMMUNITY

The spleen contributes to stroke‐induced neurodegeneration

(2008) Craig T. Ajmo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cell adhesion molecules and ischemic stroke

(2008) Gokhan Yilmaz et al.   NEUROLOGICAL RESEARCH

Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression

(2008) H. Offner et al.   NEUROSCIENCE

Antagonism of Sphingosine 1-Phosphate Receptor-2 Enhances Migration of Neural Progenitor Cells Toward an Area of Brain Infarction

(2008) Atsushi Kimura et al.   STROKE

Is It Time to Definitely Abandon Neuroprotection in Acute Ischemic Stroke?

(2008) Maria Luisa Sacchetti   STROKE