Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance?

Acute insulin deprivation results in altered mitochondrial substrate sensitivity conducive to greater fatty acid transport

(2020) Paula M. Miotto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exercising your fat (metabolism) into shape: a muscle-centred view

(2020) Anne Gemmink et al.   DIABETOLOGIA

Moderate-Intensity Exercise and High-Intensity Interval Training Affect Insulin Sensitivity Similarly in Obese Adults

(2020) Benjamin J Ryan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo

(2019) Thiago M. Batista et al.   Cell Reports

Supplementation with dietary ω-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women

(2019) Paula M. Miotto et al.   FASEB JOURNAL

Extensive metabolic remodeling after limiting mitochondrial lipid burden is consistent with an improved metabolic health profile

(2019) Sujoy Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Skeletal Muscle Mitochondrial Respiration Is Elevated in Female Cynomolgus Macaques Fed a Western Compared with a Mediterranean Diet

(2019) Jenny L Gonzalez-Armenta et al.   JOURNAL OF NUTRITION

Skeletal Muscle Energetics are Compromised Only During High Intensity Contractions in the Goto-Kakizaki Rat Model of Type 2 Diabetes

(2019) Matthew T. Lewis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Quantification of Mitochondrial Oxidative Phosphorylation in Metabolic Disease: Application to Type 2 Diabetes

(2019) Matthew T. Lewis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Short‐term bed rest‐induced insulin resistance cannot be explained by increased mitochondrial H 2 O 2 emission

(2019) Marlou L. Dirks et al.   JOURNAL OF PHYSIOLOGY-LONDON

Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with Type 2 diabetes

(2019) Maria F. Pino et al.   PHYSIOLOGICAL GENOMICS

Intramuscular triglyceride synthesis: importance in muscle lipid partitioning in humans

(2018) Bryan C. Bergman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Endurance exercise training and high-fat diet differentially affect composition of diacylglycerol molecular species in rat skeletal muscle

(2018) Noriaki Kawanishi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

High Fat Diet Causes Mitochondrial Dysfunction as a Result of Impaired ADP Sensitivity

(2018) Paula M Miotto et al.   DIABETES

Exercise counteracts lipotoxicity by improving lipid turnover and lipid droplet quality

(2018) E. Zacharewicz et al.   JOURNAL OF INTERNAL MEDICINE

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

Proteomics Analysis of Skeletal Muscle from Leptin-Deficient ob/ob Mice Reveals Adaptive Remodeling of Metabolic Characteristics and Fiber Type Composition

(2018) Milena Schönke et al.   PROTEOMICS

Training-Induced Changes in Mitochondrial Content and Respiratory Function in Human Skeletal Muscle

(2018) Cesare Granata et al.   SPORTS MEDICINE

Proteomic study of skeletal muscle in obesity and type 2 diabetes: progress and potential

(2018) Rikke Kruse et al.   Expert Review of Proteomics

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

Determinants of maximal whole body fat oxidation in elite cross-country skiers: role of skeletal muscle mitochondria

(2018) Sune Dandanell et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Exercise training remodels human skeletal muscle mitochondrial fission and fusion machinery towards a pro-elongation phenotype

(2018) Christopher L. Axelrod et al.   Acta Physiologica

Mitochondrial ATP synthase β-subunit production rate and ATP synthase specific activity are reduced in skeletal muscle of humans with obesity

(2018) Lee Tran et al.   EXPERIMENTAL PHYSIOLOGY

Decrement in resting and insulin-stimulated soleus muscle mitochondrial respiration is an early event in diet-induced obesity in mice

(2018) Henver Simionato Brunetta et al.   EXPERIMENTAL PHYSIOLOGY

ATP Production of Muscle Mitochondria after Acute Exercise in Lean and Obese Humans

(2018) Katon A. Kras et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

High-Intensity Exercise and Mitochondrial Biogenesis: Current Controversies and Future Research Directions

(2018) David J. Bishop et al.   PHYSIOLOGY

High Incomplete Skeletal Muscle Fatty Acid Oxidation Explains Low Muscle Insulin Sensitivity in Poorly Controlled T2D

(2017) Timothy P Gavin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction

(2017) Melanie Cree-Green et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Skeletal muscle insulin resistance: role of mitochondria and other ROS sources

(2017) Sergio Di Meo et al.   JOURNAL OF ENDOCRINOLOGY

Increased lipid availability for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1α promoter methylation in healthy subjects

(2017) Roy Eldor et al.   PLoS One

Physical activity prevents alterations in mitochondrial ultrastructure and glucometabolic parameters in a high-sugar diet model

(2017) Karina Barbosa de Queiroz et al.   PLoS One

Insulin Resistance Is Associated With Reduced Mitochondrial Oxidative Capacity Measured by31P-Magnetic Resonance Spectroscopy in Participants Without Diabetes From the Baltimore Longitudinal Study of Aging

(2016) Elisa Fabbri et al.   DIABETES

Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association

(2016) Sheri R. Colberg et al.   DIABETES CARE

Training intensity modulates changes in PGC-1α and p53 protein content and mitochondrial respiration, but not markers of mitochondrial content in human skeletal muscle

(2016) Cesare Granata et al.   FASEB JOURNAL

Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus

(2016) Matthijs K. C. Hesselink et al.   Nature Reviews Endocrinology

Skeletal Muscle Mitochondrial Bioenergetics and Morphology in High Fat Diet Induced Obesity and Insulin Resistance: Focus on Dietary Fat Source

(2016) Rosalba Putti et al.   Frontiers in Physiology

Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling

(2015) Alison Ludzki et al.   DIABETES

Exercise and Weight Loss Improve Muscle Mitochondrial Respiration, Lipid Partitioning, and Insulin Sensitivity After Gastric Bypass Surgery

(2015) Paul M. Coen et al.   DIABETES

Defects in Mitochondrial Efficiency and H2O2Emissions in Obese Women Are Restored to a Lean Phenotype With Aerobic Exercise Training

(2015) Adam R. Konopka et al.   DIABETES

Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats

(2015) Arend Bonen et al.   DIABETOLOGIA

Maximal fat oxidation during exercise is positively associated with 24-hour fat oxidation and insulin sensitivity in young, healthy men

(2015) Scott L. Robinson et al.   JOURNAL OF APPLIED PHYSIOLOGY

Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism

(2015) Shawna E. Wicks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle

(2014) Kristin I. Stanford et al.   ADVANCES IN PHYSIOLOGY EDUCATION

High-Fat Diet–Induced Mitochondrial Biogenesis Is Regulated by Mitochondrial-Derived Reactive Oxygen Species Activation of CaMKII

(2014) Swati S. Jain et al.   DIABETES

Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance

(2014) Darren C. Henstridge et al.   DIABETES

Can we optimise the exercise training prescription to maximise improvements in mitochondria function and content?

(2013) David J. Bishop et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

"Deficiency" of Mitochondria in Muscle Does Not Cause Insulin Resistance

(2013) J. O. Holloszy   DIABETES

Mitochondrial Deficiency Is Associated With Insulin Resistance

(2013) B. H. Goodpaster   DIABETES

Mitochondrial Respiratory Capacity and Content Are Normal in Young Insulin-Resistant Obese Humans

(2013) K. H. Fisher-Wellman et al.   DIABETES

The role of weight loss and exercise in correcting skeletal muscle mitochondrial abnormalities in obesity, diabetes and aging

(2013) Frederico G.S. Toledo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Markers of Skeletal Muscle Mitochondrial Function and Lipid Accumulation Are Moderately Associated with the Homeostasis Model Assessment Index of Insulin Resistance in Obese Men

(2013) Imtiaz A. Samjoo et al.   PLoS One

Measuring mitochondrial protein synthesis to assess biogenesis

(2012) Kevin R. Short   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effect of exercise training on insulin sensitivity, mitochondria and computed tomography muscle attenuation in overweight women with and without polycystic ovary syndrome

(2012) S. K. Hutchison et al.   DIABETOLOGIA

Exercise training-induced Regulation of Mitochondrial Quality

(2012) Zhen Yan et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Physical Activity Is the Key Determinant of Skeletal Muscle Mitochondrial Function in Type 2 Diabetes

(2012) F. H. J. van Tienen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects

(2012) Steen Larsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Long-term high-fat-diet feeding induces skeletal muscle mitochondrial biogenesis in rats in a sex-dependent and muscle-type specific manner

(2012) Yolanda Gómez-Pérez et al.   Nutrition & Metabolism

A perspective on the determination of mitochondrial biogenesis

(2011) Benjamin F. Miller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Subcellular lipid droplet distribution in red and white muscles in the obese Zucker rat

(2011) J. S. V. Lally et al.   DIABETOLOGIA

Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1β involves reductions in long-chain acyl-CoA levels and oxidative stress

(2011) L. E. Wright et al.   DIABETOLOGIA

Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide

(2011) J. J. Dubé et al.   DIABETOLOGIA

Low-volume high-intensity interval training reduces hyperglycemia and increases muscle mitochondrial capacity in patients with type 2 diabetes

(2011) Jonathan P. Little et al.   JOURNAL OF APPLIED PHYSIOLOGY

Nine Days of Intensive Exercise Training Improves Mitochondrial Function But Not Insulin Action in Adult Offspring of Mothers with Type 2 Diabetes

(2011) Brian A. Irving et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Exercise prescription for patients with type 2 diabetes and pre-diabetes: A position statement from Exercise and Sport Science Australia

(2011) Matthew D. Hordern et al.   JOURNAL OF SCIENCE AND MEDICINE IN SPORT

Low-Volume Interval Training Improves Muscle Oxidative Capacity in Sedentary Adults

(2011) MELANIE S. HOOD et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Acute elevation of plasma lipids does not affect ATP synthesis in human skeletal muscle

(2010) A. Brehm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity

(2010) Vitor A. Lira et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Acute or Chronic Upregulation of Mitochondrial Fatty Acid Oxidation Has No Net Effect on Whole-Body Energy Expenditure or Adiposity

(2010) Kyle L. Hoehn et al.   Cell Metabolism

The Role of Adipose Tissue and Lipotoxicity in the Pathogenesis of Type 2 Diabetes

(2010) Kenneth Cusi   Current Diabetes Reports

Mitochondrial metabolic function assessed in vivo and in vitro

(2010) Ian R Lanza et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Compensatory Increases in Nuclear PGC1  Protein Are Primarily Associated With Subsarcolemmal Mitochondrial Adaptations in ZDF Rats

(2010) G. P. Holloway et al.   DIABETES

Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals

(2010) E. Phielix et al.   DIABETOLOGIA

Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1α) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats

(2010) C. R. Benton et al.   DIABETOLOGIA

Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes

(2010) M. Hey-Mogensen et al.   DIABETOLOGIA

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

(2010) J. E. Ayala et al.   Disease Models & Mechanisms

Pathogenesis of Insulin Resistance in Skeletal Muscle

(2010) Muhammad A. Abdul-Ghani et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Skeletal Muscle Mitochondria in Insulin Resistance: Differences in IntermyofibrillarVersusSubsarcolemmal Subpopulations and Relationship to Metabolic Flexibility

(2010) Peter Chomentowski et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake

(2010) D. P. Olson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive oxygen species and insulin resistance: the good, the bad and the ugly

(2010) Tony Tiganis   TRENDS IN PHARMACOLOGICAL SCIENCES

Increased subsarcolemmal lipids in type 2 diabetes: effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle

(2009) Joachim Nielsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes

(2009) H. Hwang et al.   DIABETES

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

(2009) R. C.R. Meex et al.   DIABETES

Insulin Resistance Is Associated With Higher Intramyocellular Triglycerides in Type I but Not Type II Myocytes Concomitant With Higher Ceramide Content

(2009) P. M. Coen et al.   DIABETES

Maximal lipid oxidation in patients with type 2 diabetes is normal and shows an adequate increase in response to aerobic training

(2009) M. Mogensen et al.   DIABETES OBESITY & METABOLISM

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Reduced skeletal muscle mitochondrial respiration and improved glucose metabolism in nondiabetic obese women during a very low calorie dietary intervention leading to rapid weight loss

(2009) Rasmus Rabøl et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance

(2008) John O Holloszy   AMERICAN JOURNAL OF CLINICAL NUTRITION

Muscle mitochondrial changes with aging and exercise

(2008) Ian R Lanza et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet-Induced Insulin Resistance

(2008) C. R. Bruce et al.   DIABETES

Asian Indians Have Enhanced Skeletal Muscle Mitochondrial Capacity to Produce ATP in Association With Severe Insulin Resistance

(2008) K. S. Nair et al.   DIABETES

Mitochondrial Capacity in Skeletal Muscle Is Not Stimulated by Weight Loss Despite Increases in Insulin Action and Decreases in Intramyocellular Lipid Content

(2008) F. G.S. Toledo et al.   DIABETES

Training-induced improvement in lipid oxidation in type 2 diabetes mellitus is related to alterations in muscle mitochondrial activity. Effect of endurance training in type 2 diabetes

(2008) S. Bordenave et al.   DIABETES & METABOLISM

Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction

(2008) H M De Feyter et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice

(2008) Charlotte Bonnard et al.   JOURNAL OF CLINICAL INVESTIGATION

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

(2008) C. R. Hancock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA